Reactome | ITGB5 [phagocytic vesicle]

ITGB5 [phagocytic vesicle]

Stable Identifier

R-HSA-1236749

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle

Synonyms

Integrin beta-5

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
        
        Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)
        
        DC receptors recognizing apoptotic cells [phagocytic vesicle] (Homo sapiens)
        
        alphaVbeta5 [phagocytic vesicle] (Homo sapiens)
        
        ITGB5 [phagocytic vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18084 ITGB5

Gene Names

ITGB5

Chain

signal peptide:1-23, chain:24-799

Reference Genes

BioGPS Gene:3693 ITGB5

COSMIC (genes):ITGB5 ITGB5

CTD Gene:3693 ITGB5

dbSNP Gene:3693 ITGB5

ENSEMBL:ENSG00000082781.12 ITGB5

HGNC:6160 ITGB5

KEGG Gene (Homo sapiens):3693 ITGB5

Monarch:3693 ITGB5

NCBI Gene:3693 ITGB5

OMIM:147561 ITGB5

UCSC:P18084 ITGB5

Reference Transcript

RefSeq:NM_002213.4 ITGB5

Other Identifiers

11754810_a_at

16958356

201124_PM_at

201124_at

201125_PM_s_at

201125_s_at

2058_s_at

214020_PM_x_at

2692817

2692818

2692819

2692821

2692823

2692824

2692826

2692827

2692831

2692836

2692840

2692844

2692845

2692848

2692849

2692850

2692853

2692859

2692864

2692865

2692866

2692867

2692868

2692876

3693

39754_at

8090162

A_23_P166633

GE59781

GO:0001618

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005886

GO:0005925

GO:0007010

GO:0007155

GO:0007160

GO:0007179

GO:0007229

GO:0008305

GO:0009986

GO:0016020

GO:0016021

GO:0016477

GO:0023052

GO:0030154

GO:0031410

GO:0032991

GO:0033627

GO:0034684

GO:0035987

GO:0038023

GO:0043149

GO:0043226

GO:0043235

GO:0045335

GO:0046718

GO:0048856

GO:0048870

GO:0060089

GO:0070062

GO:0090136

HMNXSV003047937

Hs.149846.0.S2_3p_at

Hs.149846.1.S1_3p_a_at

ILMN_1668374

ILMN_1796755

ILMN_2311166

J05633_at

PH_hs_0009022

TC03001717.hg

X53002_s_at

g4504772_3p_a_at

Participates

as a component of

alphaVbeta5 [phagocytic vesicle] (Homo sapiens)

Other forms of this molecule

ITGB5 [plasma membrane]

Inferred To

Homologues of ITGB5 [phagocytic vesicle] (Drosophila melanogaster)

Itgb5 [phagocytic vesicle] (Mus musculus)

ITGB5 [phagocytic vesicle] (Bos taurus)

ITGB5 [phagocytic vesicle] (Canis familiaris)

ITGB5 [phagocytic vesicle] (Danio rerio)

ITGB5 [phagocytic vesicle] (Gallus gallus)

ITGB5 [phagocytic vesicle] (Sus scrofa)

ITGB5 [phagocytic vesicle] (Xenopus tropicalis)

pat-3 [phagocytic vesicle] (Caenorhabditis elegans)

Itgbn [phagocytic vesicle] (Drosophila melanogaster)

mys [phagocytic vesicle] (Drosophila melanogaster)

Cross References

RefSeq

NP_002204.2

Guide to Pharmacology - Targets

2459

OpenTargets

ENSG00000082781

GeneCards

P18084

HPA

ENSG00000082781-ITGB5

Ensembl

ENSG00000082781, ENST00000296181, ENSP00000296181

PRO

P18084

Pharos - Targets

P18084

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.564	2
UniProt:Q9BY76 ANGPTL4	2	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897)	0.564	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9HD67 MYO10	1	MYO10 [cytosol] (R-HSA-593679)	0.544	2
UniProt:P97479 Myo7a	1	Myo7a [cytosol] (R-MMU-9658865)	0.544	8