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XRCC4 [nucleoplasm]
Stable Identifier
R-HSA-75911
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein XRCC4
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
2-LTR circle formation (Homo sapiens)
2-LTR formation due to circularization of viral DNA (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
Association of XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)
XRCC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13426 XRCC4
Gene Names
XRCC4
Chain
chain:1-336, chain:266-336
Reference Genes
COSMIC (genes):XRCC4 XRCC4
dbSNP Gene:7518 XRCC4
ENSEMBL:ENSG00000152422 XRCC4
Participates
as an input of
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)
as a component of
XRCC4 homodimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K210-XRCC4 [nucleoplasm]
Inferred To
Xrcc4 [nucleoplasm]
(Mus musculus)
Xrcc4 [nucleoplasm]
(Rattus norvegicus)
XRCC4 [nucleoplasm]
(Bos taurus)
XRCC4 [nucleoplasm]
(Canis familiaris)
XRCC4 [nucleoplasm]
(Gallus gallus)
xrcc4 [nucleoplasm]
(Dictyostelium discoideum)
xrcc4 [nucleoplasm]
(Xenopus tropicalis)
Dmel\CG3448 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of XRCC4 [nucleoplasm]
(Sus scrofa)
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49917 LIG4
1
LIG4 [nucleoplasm]
(R-HSA-53791)
0.964
22
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.942
18
UniProt:Q9H9Q4 NHEJ1
1
NHEJ1 [nucleoplasm]
(R-HSA-5687247)
0.868
11
UniProt:Q8IW19 APLF
0.844
6
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.844
7
UniProt:Q8IZU0 FAM9B
0.831
9
UniProt:Q7Z2E3 APTX
0.785
6
UniProt:Q0D2I5 IFFO1
0.771
7
UniProt:P12956 XRCC6
5
XRCC6 [nucleoplasm]
(R-HSA-58272)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
0.656
3
UniProt:Q9H9Q4-1 NHEJ1
0.642
4
UniProt:O00499 BIN1
1
BIN1 [cytosol]
(R-HSA-8868265)
0.625
4
UniProt:Q0D2I5-5 IFFO1
0.591
4
UniProt:P43360 MAGA6
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q2TB18 ASTE1
0.556
3
UniProt:Q9NVX0 HAUS2
1
HAUS2 [cytosol]
(R-HSA-380274)
0.556
3
UniProt:O15499 GSC2
0.556
3
UniProt:Q13426-3 XRCC4
0.556
3
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q96QD9 FYTTD1
1
FYTTD1 [nucleoplasm]
(R-HSA-8852176)
0.527
2
UniProt:Q92624 APBP2
0.527
3
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.527
2
UniProt:Q1L5Z9 LONF2
0.527
3
UniProt:Q8IUD6 RNF135
1
RNF135 [cytosol]
(R-HSA-936042)
0.527
2
UniProt:Q9NP50 SHCAF
0.527
2
UniProt:Q5TF58 IFFO2
0.527
4
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.527
3
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.527
2
UniProt:Q96SD1 DCLRE1C
3
DCLRE1C [nucleoplasm]
(R-HSA-5686712)
p-S645-DCLRE1C [nucleoplasm]
(R-HSA-5686708)
p-S516,S645-DCLRE1C [nucleoplasm]
(R-HSA-5687176)
0.462
3
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