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NOS1 [cytosol]
Stable Identifier
R-HSA-419293
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nitric oxide synthase, brain, NOS1_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
NOS1,2,3 [cytosol] (Homo sapiens)
NOS1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)
NOS1,2,3 [cytosol] (Homo sapiens)
NOS1 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
NOS1 [cytosol] (Homo sapiens)
NOS1 [cytosol] (Homo sapiens)
PRKACA phosphorylates PLN (Homo sapiens)
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
NOS1 [cytosol] (Homo sapiens)
PRKACA phosphorylates TNNI3 (Homo sapiens)
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
NOS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29475 NOS1
Gene Names
NOS1
Chain
chain:1-1434
Reference Genes
BioGPS Gene:4842 NOS1
COSMIC (genes):NOS1 NOS1
CTD Gene:4842 NOS1
dbSNP Gene:4842 NOS1
ENSEMBL:ENSG00000089250 NOS1
HGNC:7872 NOS1
KEGG:hsa:4842 NOS1
Monarch:4842 NOS1
NCBI Gene:4842 NOS1
OMIM:163731 NOS1
UCSC:P29475 NOS1
Reference Transcript
RefSeq:XM_011538398.2 NOS1
RefSeq:XM_017019347.1 NOS1
RefSeq:NM_001204218.1 NOS1
RefSeq:NM_001204213.1 NOS1
RefSeq:XM_017019345.1 NOS1
RefSeq:NM_000620.4 NOS1
RefSeq:NM_001204214.1 NOS1
RefSeq:XM_017019346.1 NOS1
Other Identifiers
11735175_at
11735176_at
11751948_a_at
11762379_at
1560974_PM_s_at
1560974_s_at
16770848
1965_s_at
207309_PM_at
207309_at
207310_PM_s_at
207310_s_at
231916_PM_at
231916_at
239132_PM_at
239132_at
240911_PM_at
240911_at
3473523
3473525
3473526
3473527
3473528
3473529
3473530
3473531
3473532
3473533
3473534
3473535
3473537
3473538
3473540
3473541
3473542
3473543
3473544
3473545
3473546
3473547
3473548
3473549
3473550
3473551
3473552
3473553
3473554
3473556
3473557
3473558
3473559
3473562
3473563
3473567
3473576
3473577
3473578
3473581
3473582
3473584
3473585
3473692
4842
65238_at
76885_at
79398_at
7966779
85946_at
A_23_P204791
A_24_P934355
A_32_P332320
A_33_P3365167
GE54865
GE58970
GO:0001666
GO:0001917
GO:0002028
GO:0003012
GO:0003013
GO:0003824
GO:0004517
GO:0005246
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006520
GO:0006527
GO:0006809
GO:0006941
GO:0007263
GO:0007520
GO:0009408
GO:0009725
GO:0010181
GO:0010523
GO:0010882
GO:0014069
GO:0016491
GO:0016529
GO:0017080
GO:0018119
GO:0020037
GO:0032496
GO:0032991
GO:0033138
GO:0033555
GO:0034617
GO:0034618
GO:0042178
GO:0042311
GO:0042383
GO:0042995
GO:0043197
GO:0043226
GO:0043267
GO:0044325
GO:0045121
GO:0045202
GO:0045454
GO:0045776
GO:0045893
GO:0045944
GO:0046870
GO:0046872
GO:0048306
GO:0048471
GO:0050660
GO:0050661
GO:0051346
GO:0051612
GO:0051926
GO:0055117
GO:0060314
GO:0071363
GO:0071944
GO:0097110
GO:0098735
GO:0098772
GO:0106071
GO:1902307
GO:1902514
GO:1905026
HMNXSV003041233
HMNXSV003052537
Hs.192908.0.S1_3p_at
Hs.271414.0.A1_3p_at
Hs.325520.4.A1_3p_at
Hs2.407222.1.A1_3p_s_at
ILMN_1803030
PH_hs_0025073
TC12002014.hg
TC12003110.hg
U17327_at
g10835172_3p_at
g951318_3p_a_at
p26652
Participates
as an input of
ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)
as a component of
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
as a member of
NOS1,2,3 [cytosol] (Homo sapiens)
Inferred To
NOS1 [cytosol]
(Bos taurus)
NOS1 [cytosol]
(Canis familiaris)
NOS1 [cytosol]
(Danio rerio)
NOS1 [cytosol]
(Dictyostelium discoideum)
NOS1 [cytosol]
(Drosophila melanogaster)
NOS1 [cytosol]
(Gallus gallus)
NOS1 [cytosol]
(Mus musculus)
NOS1 [cytosol]
(Plasmodium falciparum)
NOS1 [cytosol]
(Rattus norvegicus)
NOS1 [cytosol]
(Saccharomyces cerevisiae)
NOS1 [cytosol]
(Schizosaccharomyces pombe)
NOS1 [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1251
OpenTargets
ENSG00000089250
ENSEMBL
ENSP00000320758
,
ENST00000317775
,
ENSP00000337459
,
ENSP00000477999
,
ENSG00000089250
,
ENST00000618760
,
ENST00000338101
HPA
ENSG00000089250-NOS1
GeneCards
NOS1
ZINC target
P29475
PRO
P29475
Pharos - Targets
P29475
Orphanet
NOS1
GlyGen
P29475
HMDB Protein
HMDBP00928
PDB
7TS1
,
6AUZ
,
5FVV
,
6NG5
,
6AV1
,
6NG6
,
6AV2
,
6PO9
,
6NG4
,
5VV3
,
5VUY
,
6AUY
,
6POC
,
5VV1
,
6PO7
,
5UO5
,
6NHB
,
6PNF
,
4UH5
,
6NG2
,
6POA
,
6NGE
,
5VUV
,
6PNC
,
8BI9
,
6POT
,
5UO3
,
8BI8
,
4UCH
,
6PND
,
6AV5
,
6NGC
,
6PO5
,
5UO7
,
6NGB
,
6NG7
,
6NGA
,
7TS5
,
8FGG
,
7TS3
,
7TS7
,
8FGJ
,
8FGL
,
6NG8
,
8FGF
,
7TS6
,
7TS8
,
6NGH
,
6AV3
,
7US7
,
8FGM
,
5ADI
,
5FVU
,
8UFP
,
5VUZ
,
6CIC
,
5VUX
,
5VV4
,
6AV0
,
4V3U
,
5ADF
,
5VV2
,
5ADG
,
4UH6
,
6NG1
,
5UO6
,
6NHC
,
5VV0
,
6PNH
,
6PNG
,
6NGF
,
6POB
,
6PO8
,
6PNB
,
4D1N
,
5UO4
,
6PNA
,
5VUW
,
6PNE
,
6NGD
,
5VV5
,
8UFQ
,
8FGI
,
5FVW
,
6CID
,
8FGK
,
6NGI
,
5UO2
,
7US8
,
7UAM
,
5UO1
,
7TS4
,
8FGH
,
7TS2
,
5FVX
,
6AV4
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.618
5
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