FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4)

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of FOXO1 (Ciechomska et al. 2003) or FOXO3 (Brunet et al. 1999, Arimoto-Ishida et al. 2004) to the promoter of the FASLG gene directly stimulates FASLG transcription. FOXO4 stimulates FASLG gene expression, as microRNA-mediated inhibition of FOXO4 mRNA translation results in decreased levels of FASLG. Direct binding of FOXO4 to the FASLG gene promoter, however, has not been demonstrated (Chen et al. 2013, Li et al. 2015). FASLG (Fas ligand) is a cytokine that belongs to the family of tumor necrosis factors involved in extrinsic apoptotic signaling. In ovarian cancer, cisplatin resistance may be partially attributable to inhibition of FOXO3-mediated induction of FASLG by PI3K/AKT signaling cascade (Arimoto-Ishida et al. 2004).
Literature References
PubMed ID Title Journal Year
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC

Cell 1999
14576824 Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells

Kaminska, B, Pyrzynska, B, Kazmierczak, P, Ciechomska, I

Oncogene 2003
26715362 microRNA-150 promotes cervical cancer cell growth and survival by targeting FOXO4

Li, J, Wu, J, Lu, F, Tian, C, Hu, L, Liu, L

BMC Mol. Biol. 2015
23707940 miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

Wang, J, Tang, Y, Xu, R, Chen, L, Yan, Z

Biochem. Biophys. Res. Commun. 2013
14701673 Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin

Takahashi, T, Ohshima, C, Arimoto-Ishida, E, Nishio, Y, Sakata, M, Ohmichi, M, Hayakawa, J, Tasaka, K, Kurachi, H, Murata, Y, Takahashi, K, Mabuchi, S, Kimura, A

Endocrinology 2004
This event is regulated
Cite Us!