FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4)

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R-HSA-9614669
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Reaction [omitted]
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Homo sapiens
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Binding of FOXO1 (Ciechomska et al. 2003) or FOXO3 (Brunet et al. 1999, Arimoto-Ishida et al. 2004) to the promoter of the FASLG gene directly stimulates FASLG transcription. FOXO4 stimulates FASLG gene expression, as microRNA-mediated inhibition of FOXO4 mRNA translation results in decreased levels of FASLG. Direct binding of FOXO4 to the FASLG gene promoter, however, has not been demonstrated (Chen et al. 2013, Li et al. 2015). FASLG (Fas ligand) is a cytokine that belongs to the family of tumor necrosis factors involved in extrinsic apoptotic signaling. In ovarian cancer, cisplatin resistance may be partially attributable to inhibition of FOXO3-mediated induction of FASLG by PI3K/AKT signaling cascade (Arimoto-Ishida et al. 2004).

Literature References
PubMed ID Title Journal Year
14576824 Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells

Ciechomska, I, Pyrzynska, B, Kazmierczak, P, Kaminska, B

Oncogene 2003
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
26715362 microRNA-150 promotes cervical cancer cell growth and survival by targeting FOXO4

Li, J, Hu, L, Tian, C, Lu, F, Wu, J, Liu, L

BMC Mol. Biol. 2015
23707940 miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

Chen, L, Tang, Y, Wang, J, Yan, Z, Xu, R

Biochem. Biophys. Res. Commun. 2013
14701673 Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin

Arimoto-Ishida, E, Ohmichi, M, Mabuchi, S, Takahashi, T, Ohshima, C, Hayakawa, J, Kimura, A, Takahashi, K, Nishio, Y, Sakata, M, Kurachi, H, Tasaka, K, Murata, Y

Endocrinology 2004
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