Reactome | FASLG [extracellular region]

FASLG [extracellular region]

Stable Identifier

R-GGA-66212

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

extracellular region

Synonyms

FASLG(1-281), A0A8V0YN18

Locations in the PathwayBrowser

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Programmed Cell Death (Gallus gallus)

- Apoptosis (Gallus gallus)
  - Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
    - Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
      - Dimerization of procaspase-8 (Gallus gallus)
        
        FAS-mediated dimerization of procaspase-8 (Gallus gallus)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
      - Regulation by c-FLIP (Gallus gallus)
        
        Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
- Regulated Necrosis (Gallus gallus)
  - RIPK1-mediated regulated necrosis (Gallus gallus)
    - Regulation of necroptotic cell death (Gallus gallus)
      - CASP8 activity is inhibited (Gallus gallus)
        
        FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Gallus gallus)
        
        FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)
        
        FASLG [extracellular region] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0YN18

Gene Names

FASLG

Reference Genes

BioGPS Gene:429064 FASLG

ENSEMBL:ENSGALG00010013583.1

KEGG:gga:429064 FASLG

Monarch:429064 FASLG

NCBI Gene:429064 FASLG

UCSC:A0A8V0YN18 FASLG

Reference Transcript

RefSeq:NM_001031559.2 FASLG

Other Identifiers

429064

GO:0000122

GO:0002376

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005764

GO:0005886

GO:0006355

GO:0006915

GO:0006955

GO:0008625

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0016525

GO:0031410

GO:0043065

GO:0043123

GO:0043202

GO:0046666

GO:0048018

GO:0055085

GO:0060205

GO:0061024

GO:0070062

GO:0070231

GO:0070266

GO:0097190

GO:0097191

GO:0097527

GO:0098772

GO:1903514

GO:1905782

GO:2000353

GO:2001238

GT_A_87_P035509

Gga.9365.1.A1_at

GgaAffx.1941.1.S1_at

Participates

as an input of

FASL binds FAS Receptor (Gallus gallus)

as a component of

FASL:FAS Receptor monomer [plasma membrane] (Gallus gallus)

Inferred From

FASLG(1-281) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001026730.2

ENSEMBL

ENSGALG00010013583, ENSGALP00010019343, ENSGALT00010032642

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