FADD [cytosol]

Stable Identifier
R-HSA-54639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity), FADD protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity
Icon
FADD [cytosol] icon
FADD [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
7538907 FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

Dixit, VM, Tewari, M, O'Rourke, K, Chinnaiyan, AM

Cell 1995
External Reference Information
External Reference
UniProt:Q13158 FADD
Gene Names
FADD, MORT1, GIG3
Chain
chain:1-208
Reference Genes
BioGPS Gene:8772 FADD
COSMIC (genes):FADD FADD
CTD Gene:8772 FADD
dbSNP Gene:8772 FADD
ENSEMBL:ENSG00000168040 FADD
HGNC:3573 FADD
KEGG:hsa:8772 FADD
Monarch:8772 FADD
NCBI Gene:8772 FADD
OMIM:602457 FADD
UCSC:Q13158 FADD
Reference Transcript
Other Identifiers
11716799_at
11716800_at
16728331
202535_PM_at
202535_at
3338425
3338426
3338427
3338428
3338431
3338432
3338433
3338434
3338435
38755_at
7942168
8772
A_14_P110132
A_14_P123448
A_23_P86917
A_24_P278637
GE60092
GO:0001822
GO:0001916
GO:0002020
GO:0002376
GO:0002821
GO:0005123
GO:0005164
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006915
GO:0007165
GO:0008625
GO:0009898
GO:0012501
GO:0030154
GO:0030674
GO:0031264
GO:0031265
GO:0032729
GO:0032757
GO:0032760
GO:0032813
GO:0032991
GO:0033077
GO:0033612
GO:0035591
GO:0035877
GO:0036462
GO:0042104
GO:0042220
GO:0042802
GO:0042981
GO:0043029
GO:0043065
GO:0043123
GO:0044297
GO:0044877
GO:0045087
GO:0045089
GO:0045651
GO:0045862
GO:0045944
GO:0048148
GO:0048535
GO:0048536
GO:0048538
GO:0048856
GO:0051604
GO:0051607
GO:0060090
GO:0060340
GO:0060544
GO:0060546
GO:0065003
GO:0070236
GO:0071260
GO:0071550
GO:0089720
GO:0097049
GO:0097190
GO:0097191
GO:0097192
GO:0097202
GO:0097342
GO:0097527
GO:0098542
GO:1900119
GO:2000454
GO:2001238
HMNXSV003047418
ILMN_1758658
PH_hs_0004852
TC11000723.hg
X84709_at
g4505228_3p_at
Participates
as a component of
as an input of
Inferred To
FADD [cytosol] (Bos taurus)
FADD [cytosol] (Gallus gallus)
Fadd [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Mus musculus)
Fadd [cytosol] (Rattus norvegicus)
Ghost homologue of FADD [cytosol] (Canis familiaris)
Ghost homologue of FADD [cytosol] (Xenopus tropicalis)
TNFRSF6 [cytosol] (Sus scrofa)
Cross References
RefSeq
OpenTargets
ENSEMBL
HPA
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (33)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14790 CASP8  8 0.98 47
 UniProt:P25445 FAS  1 0.96 23
 UniProt:Q13546 RIPK1  20 0.928 12
 UniProt:P50591 TNFSF10  1 0.913 19
 UniProt:Q13158 FADD  1 0.885 12
 UniProt:P25445-1 FAS      0.883 17
 UniProt:Q15628 TRADD  1 0.806 7
 UniProt:P25446  1 0.772 8
 UniProt:Q92851 CASP10  4 0.75 4
 UniProt:P48023 FASLG  1 0.731 4
 UniProt:O00220 TNFRSF10A  1 0.725 6
 UniProt:P53350 PLK1  4 0.676 9
 UniProt:Q99497 PARK7  7 0.653 9
 UniProt:B7UI21 NLEB1      0.593 7
 UniProt:P03126 VE6      0.593 4
 UniProt:O95243 MBD4  1 0.581 6
 UniProt:Q99836 MYD88  8 0.573 3
 UniProt:Q14790-5 CASP8      0.567 4
 UniProt:P62324 BTG1  1 0.556 5
 UniProt:B7ZLH0 B7ZLH0      0.556 3
 UniProt:P78317 RNF4  2 0.556 5
 UniProt:O00560 SDCBP  3 0.556 6
 UniProt:Q6PEW1 ZCH12      0.556 3
 UniProt:Q96D03 DDT4L      0.556 3
 UniProt:Q7KZS0 Q7KZS0      0.556 3
 UniProt:Q9UJ78-2 Q9UJ782      0.556 3
 UniProt:Q15560 TCEA2      0.556 3
 UniProt:O14763 TNFRSF10B  1 0.527 4
 UniProt:O43422 P52K      0.527 2
 UniProt:Q9Y6K9 IKBKG  12 0.527 2
 IntAct:EBI-16074260 EHECNLEB1      0.508 2
 UniProt:Q5S007 LRRK2  1 0.499 4
 UniProt:Q14790-1 CASP8      0.482 5
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