Expression of FASLG

Stable Identifier
R-HSA-6797245
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, nucleoplasm
ReviewStatus
5/5
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Expression of FASLG
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes that are downregulated by STAT3 include the extracellular protein Tumor necrosis factor ligand superfamily member 6 (FASLG) (Ivanov et al. 2001).
Literature References
PubMed ID Title Journal Year
11463377 Cooperation between STAT3 and c-jun suppresses Fas transcription

Raz, R, Horvath, CM, Owen-Schaub, LB, Ivanov, VN, Levy, D, Bhoumik, A, Ronai, Z, Krasilnikov, M

Mol. Cell 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-09-07)
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