Reactome | ARHGEF1 [cytosol]

ARHGEF1 [cytosol]

Stable Identifier

R-HSA-114526

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92888 ARHGEF1

Gene Names

ARHGEF1

Chain

chain:1-912

Reference Genes

BioGPS Gene:9138 ARHGEF1

COSMIC (genes):ARHGEF1 ARHGEF1

CTD Gene:9138 ARHGEF1

dbSNP Gene:9138 ARHGEF1

ENSEMBL:ENSG00000076928 ARHGEF1

ENSEMBL:ENSG00000076928.20 ARHGEF1

HGNC:681 ARHGEF1

KEGG Gene (Homo sapiens):9138 ARHGEF1

Monarch:9138 ARHGEF1

NCBI Gene:9138 ARHGEF1

OMIM:601855 ARHGEF1

UCSC:Q92888 ARHGEF1

Reference Transcript

Other Identifiers

11743008_a_at

11743009_x_at

11744761_x_at

11755433_x_at

16862613

203055_PM_s_at

203055_s_at

3834520

3834521

3834522

3834525

3834526

3834527

3834528

3834533

3834534

3834536

3834537

3834538

3834539

3834540

3834541

3834542

3834549

3834550

3834551

3834552

3834553

3834554

3834555

3834557

3834559

3834560

3834561

3834562

3834565

3834566

3834569

3834571

3834573

38445_at

8029147

810_at

9138

A_14_P100937

GE59306

GO:0001664

GO:0003723

GO:0005085

GO:0005096

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0007186

GO:0007266

GO:0016020

GO:0023052

GO:0051056

GO:0098772

HMNXSV003006758

HMNXSV003039477

ILMN_2293131

TC19000589.hg

U64105_at

g4759189_3p_a_at

Participates

as a member of

as an input of

G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)

as a component of

G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)

Inferred To

ARHGEF1 [cytosol] (Bos taurus)

ARHGEF1 [cytosol] (Canis familiaris)

ARHGEF1 [cytosol] (Sus scrofa)

RhoGEF2 [cytosol] (Drosophila melanogaster)

im:7155372 [cytosol] (Danio rerio)

arhgef1 [cytosol] (Xenopus tropicalis)

rhgf-1 [cytosol] (Caenorhabditis elegans)

Arhgef1 [cytosol] (Mus musculus)

Arhgef1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_945353.1, NP_004697.2, NP_945328.1

OpenTargets

ENSG00000076928

HPA

ENSG00000076928-ARHGEF1

GeneCards

Q92888

Ensembl

ENSP00000344429, ENST00000337665, ENST00000378152, ENST00000347545, ENSP00000337261, ENSG00000076928, ENST00000354532, ENSP00000367394, ENSP00000346532

PRO

Q92888

Pharos - Targets

Q92888

Orphanet

28716

HMDB Protein

HMDBP01669

PDB

3ODX, 1SHZ, 3ODO, 3AB3, 1IAP, 3ODW, 3P6A

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7DB74 Q7DB74			0.599	7
UniProt:Q14344 GNA13	1	GNA13 [plasma membrane] (R-HSA-167451)	0.564	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3