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ARHGEF1 [cytosol]
Stable Identifier
R-HSA-114526
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
p115-RhoGEF activation of RHOA (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92888 ARHGEF1
Gene Names
ARHGEF1
Chain
chain:1-912
Reference Genes
BioGPS Gene:9138 ARHGEF1
COSMIC (genes):ARHGEF1 ARHGEF1
CTD Gene:9138 ARHGEF1
dbSNP Gene:9138 ARHGEF1
ENSEMBL:ENSG00000076928 ARHGEF1
HGNC:681 ARHGEF1
KEGG:hsa:9138 ARHGEF1
Monarch:9138 ARHGEF1
NCBI Gene:9138 ARHGEF1
OMIM:601855 ARHGEF1
UCSC:Q92888 ARHGEF1
Reference Transcript
RefSeq:NM_199002.2 ARHGEF1
RefSeq:NM_004706.3 ARHGEF1
RefSeq:NM_198977.2 ARHGEF1
Other Identifiers
11743008_a_at
11743009_x_at
11744761_x_at
11755433_x_at
1560445_PM_x_at
1560445_x_at
16862613
16862643
203055_PM_s_at
203055_s_at
3834520
3834521
3834522
3834525
3834526
3834527
3834528
3834529
3834530
3834531
3834532
3834533
3834534
3834535
3834536
3834537
3834538
3834539
3834540
3834541
3834542
3834543
3834544
3834545
3834546
3834547
3834548
3834549
3834550
3834551
3834552
3834553
3834554
3834555
3834556
3834557
3834558
3834559
3834560
3834561
3834562
3834563
3834564
3834565
3834566
3834567
3834568
3834569
3834570
3834571
3834572
3834573
3834576
3834577
3834578
3834579
38445_at
3871487
65229_at
8029147
810_at
9138
ADDON000479.hg
ADDON002055.hg
A_14_P100937
A_14_P113980
A_14_P139176
A_23_P101321
A_24_P202581
A_33_P3290089
A_33_P3292864
A_33_P3292874
GE59306
GO:0001664
GO:0003723
GO:0005085
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007186
GO:0007266
GO:0016020
GO:0051056
GO:0098772
GO:0160221
HMNXSV003000047
HMNXSV003006758
HMNXSV003014747
HMNXSV003015041
HMNXSV003024227
HMNXSV003033093
HMNXSV003039477
ILMN_1772370
ILMN_2293131
ILMN_2405129
PH_hs_0028078
TC19000589.hg
U64105_at
g4759189_3p_a_at
p25114
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
as a component of
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
as an input of
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)
Inferred To
ARHGEF1 [cytosol]
(Bos taurus)
ARHGEF1 [cytosol]
(Canis familiaris)
ARHGEF1 [cytosol]
(Sus scrofa)
RhoGEF2 [cytosol]
(Drosophila melanogaster)
rhgf-1 [cytosol]
(Caenorhabditis elegans)
Arhgef1 [cytosol]
(Mus musculus)
Arhgef1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_945353.1
,
NP_945328.1
,
NP_004697.2
ENSEMBL
ENST00000337665
,
ENSP00000337261
,
ENST00000347545
,
ENST00000354532
,
ENSP00000367394
,
ENSP00000346532
,
ENSG00000076928
,
ENST00000378152
,
ENSP00000344429
OpenTargets
ENSG00000076928
GeneCards
ARHGEF1
HPA
ENSG00000076928-ARHGEF1
PRO
Q92888
Pharos - Targets
Q92888
GlyGen
Q92888
HMDB Protein
HMDBP01669
PDB
3AB3
,
1IAP
,
3P6A
,
3ODO
,
1SHZ
,
3ODW
,
3ODX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7DB74 Q7DB74
0.599
7
UniProt:Q14344 GNA13
1
GNA13 [plasma membrane]
(R-HSA-167451)
0.564
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:P62745 RHOB
3
RHOB [endosome membrane]
(R-HSA-5666064)
RHOB [cytosol]
(R-HSA-194855)
RHOB [plasma membrane]
(R-HSA-194891)
0.547
2
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.527
2
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