Reactome | p-T37,T46-EIF4EBP1 [cytosol]

p-T37,T46-EIF4EBP1 [cytosol]

Stable Identifier

R-HSA-165685

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

4E-BP1-P

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13541 EIF4EBP1

Gene Names

EIF4EBP1

Chain

initiator methionine:, chain:2-118

Reference Genes

BioGPS Gene:1978 EIF4EBP1

COSMIC (genes):EIF4EBP1 EIF4EBP1

CTD Gene:1978 EIF4EBP1

dbSNP Gene:1978 EIF4EBP1

ENSEMBL:ENSG00000187840 EIF4EBP1

HGNC:3288 EIF4EBP1

KEGG:hsa:1978 EIF4EBP1

Monarch:1978 EIF4EBP1

NCBI Gene:1978 EIF4EBP1

OMIM:602223 EIF4EBP1

UCSC:Q13541 EIF4EBP1

Reference Transcript

RefSeq:NM_004095.3 EIF4EBP1

Other Identifiers

11718283_a_at

11718284_x_at

11763248_x_at

17067963

1978

221539_PM_at

221539_at

31597_r_at

4049863

4049864

4049865

4049868

4049875

4049876

54152_at

8145889

A_23_P22224

GE79604

GE87606

GO:0000082

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0008190

GO:0017148

GO:0030371

GO:0031369

GO:0031929

GO:0043226

GO:0045182

GO:0045931

GO:0045947

HMNXSV003013289

ILMN_1767324

PH_hs_0028337

TC08000281.hg

g11527778_3p_at

Participates

as an output of

Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)

as a component of

eIF4E:4E-BP1-P [cytosol] (Homo sapiens)

Other forms of this molecule

EIF4EBP1 [cytosol]

Inferred To

phospho-eif4ebp1 [cytosol] (Danio rerio)

phospho-EIF4EBP1 [cytosol] (Bos taurus)

phospho-EIF4EBP1 [cytosol] (Canis familiaris)

phospho-EIF4EBP1 [cytosol] (Sus scrofa)

phospho-Eif4ebp1 [cytosol] (Mus musculus)

phospho-Eif4ebp1 [cytosol] (Rattus norvegicus)

phospho-febA [cytosol] (Dictyostelium discoideum)

phospho-p-T37,T46-EIF4EBP1 [cytosol] (Gallus gallus)

phospho-Thor [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 37

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 46

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

OpenTargets

ENSG00000187840

ENSEMBL

ENST00000338825, ENSP00000340691, ENSG00000187840

HPA

ENSG00000187840-EIF4EBP1

GeneCards

EIF4EBP1

PRO

Q13541

Pharos - Targets

Q13541

GlyGen

Q13541

PDB

3HXG, 1WKW, 5NVN, 1EJH, 2V8Y, 2V8W, 3U7X, 2JGB, 2JGC, 5WBJ, 5BXV, 2V8X, 8RCK, 6BCX, 4UED, 1EJ4, 6BCU, 8RCH, 3M94, 3HXI, 5EKV, 3M93, 8RCN

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.981	34
UniProt:Q8N122 RPTOR	3	p-S722,S792-RPTOR [cytosol] (R-HSA-3132767) RPTOR [cytosol] (R-HSA-3006727) RPTOR [nucleoplasm] (R-HSA-5083664)	0.711	5
UniProt:O60573-1 EIF4E2			0.669	6
UniProt:A6NMX2 I4E1B			0.666	4
UniProt:P06730-1 EIF4E			0.591	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.564	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
IntAct:EBI-22653406 CCSB ORF ID			0.556	5
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
ChEBI:50210 7-METHYL-GTP			0.527	3
UniProt:Q9JLN9	2	MTOR [nucleoplasm] (R-MMU-5083674) MTOR [cytosol] (R-MMU-165662)	0.525	2
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.524	2

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