Reactome | p-5Y-FRS3 [plasma membrane]

p-5Y-FRS3 [plasma membrane]

Stable Identifier

R-HSA-191475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-FRS2-beta

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - ALK fusions phosphorylate FRS (Homo sapiens)
        
        ALK fusions:p-6Y FRS [cytosol] (Homo sapiens)
        
        Phospho-FRS2 [plasma membrane] (Homo sapiens)
        
        p-5Y-FRS3 [plasma membrane] (Homo sapiens)

General

The phospho-tyrosine positions for FRS2-beta were inferred by similarity to the analogous positions in FRS2-alpha. Five out of six tyrosine positions in alpha are present in beta.

External Reference Information

External Reference

UniProt:O43559 FRS3

Gene Names

FRS3

Chain

initiator methionine:1, chain:2-492

Reference Genes

BioGPS Gene:10817 FRS3

COSMIC (genes):FRS3 FRS3

CTD Gene:10817 FRS3

dbSNP Gene:10817 FRS3

ENSEMBL:ENSG00000137218 FRS3

ENSEMBL:ENSG00000137218.10 FRS3

HGNC:16970 FRS3

KEGG Gene (Homo sapiens):10817 FRS3

Monarch:10817 FRS3

NCBI Gene:10817 FRS3

OMIM:607744 FRS3

UCSC:O43559 FRS3

Reference Transcript

Other Identifiers

10817

11727216_at

17019121

219907_PM_at

219907_at

2953778

2953779

2953780

2953782

2953783

2953786

2953788

2953790

8126337

83768_at

A_23_P167970

A_33_P3270295

GE62391

GO:0005068

GO:0005104

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0008543

GO:0016020

GO:0023052

GO:0042802

GO:0060090

HMNXSV003013050

ILMN_1772605

PH_hs_0011463

TC06001723.hg

g5730058_3p_at

Participates

as a member of

Phospho-FRS2 [plasma membrane] (Homo sapiens)

as a component of

Other forms of this molecule

FRS3 [plasma membrane]

p-Y-FRS3 [plasma membrane]

Inferred To

phospho-Frs3 [plasma membrane] (Mus musculus)

phospho-Frs3 [plasma membrane] (Rattus norvegicus)

phospho-Dmel\CG13398 [plasma membrane] (Drosophila melanogaster)

phospho-p-5Y-FRS3 [plasma membrane] (Canis familiaris)

phospho-p-5Y-FRS3 [plasma membrane] (Danio rerio)

phospho-p-5Y-FRS3 [plasma membrane] (Gallus gallus)

Ghost homologue of p-5Y-FRS3 [plasma membrane] (Xenopus tropicalis)

phospho-FRS3 [plasma membrane] (Bos taurus)

phospho-FRS3 [plasma membrane] (Sus scrofa)

phospho-rog-1 [plasma membrane] (Caenorhabditis elegans)

Modified Residues

Name

O4'-phospho-L-tyrosine at 192

Coordinate

192

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 287

Coordinate

287

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 322

Coordinate

322

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 420

Coordinate

420

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 455

Coordinate

455

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011512556.1, XP_011512557.1, NP_006644.1

OpenTargets

ENSG00000137218

HPA

ENSG00000137218-FRS3

GeneCards

O43559

Ensembl

ENSG00000137218, ENSP00000259748, ENST00000259748, ENST00000373018, ENSP00000362109

PRO

O43559

Pharos - Targets

O43559

PDB

2YS5, 2KUP, 2YT2, 2KUQ

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15654 TRIP6			0.718	6
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.718	6
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.703	5
UniProt:Q9WMX2-PRO_0000037548			0.57	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.57	3
UniProt:Q9H079 KTBL1			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q8WVV4-1 POF1B			0.556	3
UniProt:Q9UFD9 RIM3A			0.556	3
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.556	3
UniProt:P27658 COL8A1	20	3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173246) GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173055) 3x4Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173183) 3x4Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173195) 3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173270) GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173122) COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172239) 3x4Hyp-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172948) 3x4Hyp-3Hyp-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172976) 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173143) 3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173217) 5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173023) 3x4Hyp-3Hyp-COL8A1(28-?) [extracellular region] (R-HSA-2470362) GalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470331) 3x4Hyp-3Hyp-COL8A1(?-744) [extracellular region] (R-HSA-2470328) 3x4Hyp-3Hyp-GalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470329) 3x4Hyp-5Hyl-COL8A1(?-744) [extracellular region] (R-HSA-2470366) GalHyl-COL8A1(28-?) [extracellular region] (R-HSA-2470364) 5Hyl-COL8A1(?-744) [extracellular region] (R-HSA-2470333) COL8A1(?-744) [extracellular region] (R-HSA-2470355)	0.556	3
UniProt:Q6ZU52 K0408			0.556	3
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	3
UniProt:A8MV65-2 VGLL3			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q7Z5V6-2 PPP1R32			0.556	3
UniProt:P0DPK4 NT2NC			0.556	3
UniProt:Q3KP44 ANR55			0.556	3
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.556	3
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q08117-2 TLE5			0.556	5
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.556	3
UniProt:Q9NWS9-2 ZNF446			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q9UC07-2 ZNF69			0.556	3
UniProt:O43597 SPRY2	8	p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629)	0.556	3
UniProt:Q5BKX5-3 ACTMAP			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q9NYG5-2 ANAPC11			0.556	3
UniProt:Q6NVV7 CDPF1			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	5
UniProt:A2VCK2 DCD2B			0.556	3
UniProt:Q01546 KRT76	1	KRT76 [cytosol] (R-HSA-6809633)	0.556	3
UniProt:Q8IWL8 STH			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
IntAct:EBI-22320813 CCSB ORF ID			0.556	3
UniProt:Q8NF64-3 ZMIZ2			0.556	3
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:P48745 CCN3			0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	5
UniProt:P15976-2 GATA1			0.556	5
UniProt:Q8N1D0-2 SLC22A18AS			0.556	3
UniProt:Q5T749 KPRP			0.556	5
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q9H707 ZNF552	1	ZNF552 [nucleoplasm] (R-HSA-1973877)	0.556	3
UniProt:Q8N456 LRC18			0.556	3
UniProt:Q8TAV5 KC5S1			0.556	3
UniProt:O14817 TSN4			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
UniProt:Q6P5X5 CV039			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:Q9H5F2 CFA68			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q9NQ30 ESM1			0.556	3
UniProt:Q9ULR0-1 Q9ULR01			0.556	3
UniProt:Q5JXC2 MIIP			0.556	3
UniProt:Q16610 ECM1	2	ECM1 [extracellular region] (R-HSA-8848909) ECM1 [platelet dense granule lumen] (R-HSA-8848880)	0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q6IA69 NADSYN1	1	NADSYN1 [cytosol] (R-HSA-197231)	0.556	3
UniProt:P35452-2 P354522			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q92824-2 PCSK5			0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
UniProt:Q9H9P5-5 UNKL			0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:Q9Y342 PLLP			0.556	3
UniProt:A0A0U1RQF7 DP2NB			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:O15162 PLS1			0.556	3
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.556	3
UniProt:Q6P1J6-2 PLB1			0.556	3
UniProt:Q7Z6I5 SPT12			0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q86W11 ZSC30			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	7
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q96FE5 LINGO1	1	LINGO1 [plasma membrane] (R-HSA-3006563)	0.556	3
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.508	2
UniProt:P08631-2 HCK			0.508	2
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.488	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.488	2
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.488	2