Reactome | GEM [plasma membrane]

GEM [plasma membrane]

Stable Identifier

R-HSA-9769962

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

GTP-binding protein GEM, GEM_HUMAN, GTP-binding mitogen-induced T-cell protein, RAS-like protein KIR, KIR

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55040 GEM

Gene Names

GEM, KIR

Chain

chain:1-296

Reference Genes

BioGPS Gene:2669 GEM

COSMIC (genes):GEM GEM

CTD Gene:2669 GEM

dbSNP Gene:2669 GEM

ENSEMBL:ENSG00000164949 GEM

ENSEMBL_homo_sapiens_GENE:ENSG00000164949.8 GEM

HGNC:4234 GEM

KEGG Gene (Homo sapiens):2669 GEM

Monarch:2669 GEM

NCBI Gene:2669 GEM

OMIM:600164 GEM

UCSC:P55040 GEM

Reference Transcript

Other Identifiers

11720558_a_at

17079210

204472_PM_at

204472_at

2669

3144935

3144936

3144937

3144938

3144941

3144948

3144949

3144953

3144954

37279_at

8151816

A_23_P257043

GE58914

GO:0000166

GO:0000278

GO:0000287

GO:0002376

GO:0003824

GO:0003924

GO:0005246

GO:0005515

GO:0005516

GO:0005525

GO:0005634

GO:0005856

GO:0005886

GO:0006955

GO:0007059

GO:0007165

GO:0007166

GO:0009898

GO:0016020

GO:0016787

GO:0019003

GO:0023052

GO:0030496

GO:0043226

GO:0051233

GO:0051276

GO:0051310

GO:0055085

GO:0072686

GO:0098772

GO:1901842

HMNXSV003008060

ILMN_1677092

ILMN_1678968

ILMN_2367883

PH_hs_0004561

TC08001432.hg

U10550_at

g4885262_3p_at

g4885262_3p_x_at

Participates

as an output of

NPAS4 stimulates GEM gene expression (Homo sapiens)

Cross References

RefSeq

NP_859053.1, NP_005252.1

OpenTargets

ENSG00000164949

GeneCards

P55040

HPA

ENSG00000164949-GEM

Ensembl

ENST00000396194, ENSP00000379497, ENSG00000164949, ENST00000297596, ENSP00000297596

PRO

P55040

Pharos - Targets

P55040

HMDB Protein

HMDBP11454

PDB

2CJW, 2HT6, 2G3Y

Interactors (116)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36406 TRI23			0.817	7
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.781	7
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.742	5
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.718	6
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.718	8
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q9UKT9 IKZF3			0.718	8
UniProt:Q7L273 KCTD9			0.718	6
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.718	6
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.718	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.718	6
UniProt:Q5JR59-3 MTUS2			0.666	6
UniProt:Q9UJV3-2 MID2			0.666	4
UniProt:P54284 CACNB3	2	CACNB3 [cytosol] (R-HSA-210401) CACNB3 [plasma membrane] (R-HSA-532201)	0.601	8
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.597	4
UniProt:Q02641 CACNB1	2	CACNB1 [cytosol] (R-HSA-210493) CACNB1 [plasma membrane] (R-HSA-532197)	0.589	3
UniProt:Q9H079 KTBL1			0.556	5
UniProt:Q8WVV4-1 POF1B			0.556	3
UniProt:Q9NWS0 PIHD1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q59EK9 RUN3A			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q9UDY6-2 TRIM10			0.556	3
UniProt:Q96R06 SPAG5			0.556	3
IntAct:EBI-10171556 147700			0.556	3
UniProt:P17568 NDUFB7	1	NDUFB7 [mitochondrial inner membrane] (R-HSA-59940)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q9P2M1 LR2BP			0.556	3
UniProt:Q96MW5 COG8	2	COG8 [trans-Golgi network membrane] (R-HSA-6813875) COG8 [Golgi membrane] (R-HSA-6808728)	0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:Q9UK41-2 VPS28			0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:O75031 HSF2B			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:Q9UDW3 ZMAT5	1	ZMAT5 [nucleoplasm] (R-HSA-6787850)	0.556	3
UniProt:Q86U28 ISCA2	1	ISCA2 [mitochondrial matrix] (R-HSA-5691207)	0.556	3
UniProt:Q9HD26-2 GOPC			0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:Q8NDD1-6 Q8NDD16			0.556	3
UniProt:P02538 KRT6A	1	KRT6A [cytosol] (R-HSA-6809654)	0.556	3
UniProt:P78385 KRT83	1	KRT83 [cytosol] (R-HSA-6809636)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q05D60 DEUP1			0.556	6
UniProt:Q9UPG8 PLAL2			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q1MX18 INSC			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P15173 MYOG	1	MYOG [nucleoplasm] (R-HSA-445160)	0.556	3
UniProt:A0A0C4DFN3 A0A0C4DFN3			0.556	3
UniProt:Q4VC12 MSS51			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.556	3
UniProt:O60641-3 SNAP91			0.556	3
UniProt:Q8N2N9-4 ANKRD36B			0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:P0C7X2 ZNF688	1	ZNF688 [nucleoplasm] (R-HSA-2248884)	0.556	3
UniProt:Q6PI77 GASP3			0.556	3
UniProt:Q9H707 ZNF552	1	ZNF552 [nucleoplasm] (R-HSA-1973877)	0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q6DHY5 TBC3G			0.556	3
UniProt:Q495M9 USH1G	1	USH1G [cytosol] (R-HSA-9658869)	0.556	3
UniProt:Q8NFT6-2 DBF4B			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.556	3
UniProt:Q8WXK1 ASB15	1	ASB15 [cytosol] (R-HSA-975426)	0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:Q9NWH7-2 Q9NWH72			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q9NQZ6 ZC4H2			0.556	3
UniProt:Q6QNY1 BL1S2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:P48059-3 LIMS1			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q13049 TRIM32	1	TRIM32 [cytosol] (R-HSA-976030)	0.556	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	5
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:P27884 CAC1A			0.499	2
UniProt:P54287 Cacnb3	2	Voltage-dependent L-type calcium channel subunit beta-3 [plasma membrane] (R-RNO-446472) Cacnb3 [cytosol] (R-RNO-210401)	0.499	2

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