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ORC4 [nucleoplasm]
Stable Identifier
R-HSA-68519
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Orc4, Origin recognition complex subunit 4
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Formation of ORC(1-5) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Formation of ORC(1-6) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Formation of ORC(2-5) complex (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDC6 association with the ORC:origin complex (Homo sapiens)
CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43929 ORC4
Gene Names
ORC4, ORC4L
Chain
chain:1-436
Reference Genes
BioGPS Gene:5000 ORC4
COSMIC (genes):ORC4 ORC4
CTD Gene:5000 ORC4
dbSNP Gene:5000 ORC4
ENSEMBL:ENSG00000115947 ORC4
HGNC:8490 ORC4
KEGG:hsa:5000 ORC4
Monarch:5000 ORC4
NCBI Gene:5000 ORC4
OMIM:603056 ORC4
UCSC:O43929 ORC4
Reference Transcript
RefSeq:NM_002552.4 ORC4
RefSeq:XM_017004227.1 ORC4
RefSeq:XM_017004226.1 ORC4
RefSeq:NM_001190882.2 ORC4
RefSeq:NM_181741.3 ORC4
RefSeq:XM_011511255.2 ORC4
RefSeq:NM_181742.3 ORC4
RefSeq:NM_001190879.2 ORC4
RefSeq:NM_001190881.2 ORC4
Other Identifiers
11730783_a_at
11730784_x_at
11744978_a_at
16903427
203351_PM_s_at
203351_s_at
203352_PM_at
203352_at
2580297
2580299
2580301
2580302
2580303
2580305
2580306
2580307
2580308
2580309
2580310
2580311
2580312
2580313
2580314
2580315
2580316
2580317
2580318
2580319
2580320
2580321
2580322
2580323
2580324
2580325
2580327
2580328
2580329
2580330
2580334
2580335
2580336
2580337
2580339
2580342
2580343
2580344
2580345
36481_at
5000
8055645
A_23_P131149
A_32_P141612
GE61725
GE85174
GO:0000166
GO:0000781
GO:0000808
GO:0000910
GO:0003677
GO:0003688
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005664
GO:0005730
GO:0005737
GO:0005829
GO:0006260
GO:0006270
GO:0016787
GO:0016887
GO:0022414
GO:0040038
GO:0043226
GO:0051258
GO:0065003
HMNXSV003017417
ILMN_1740083
PH_hs_0025726
PH_hs_0036013
TC02002408.hg
g2906225_3p_a_at
g4505522_3p_at
p26096
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
as an input of
Formation of ORC(2-5) complex (Homo sapiens)
Inferred To
orc4 [nucleoplasm]
(Danio rerio)
orc4 [nucleoplasm]
(Xenopus tropicalis)
ORC4 [nucleoplasm]
(Bos taurus)
ORC4 [nucleoplasm]
(Canis familiaris)
ORC4 [nucleoplasm]
(Dictyostelium discoideum)
ORC4 [nucleoplasm]
(Gallus gallus)
ORC4 [nucleoplasm]
(Mus musculus)
ORC4 [nucleoplasm]
(Rattus norvegicus)
ORC4 [nucleoplasm]
(Saccharomyces cerevisiae)
ORC4 [nucleoplasm]
(Schizosaccharomyces pombe)
ORC4 [nucleoplasm]
(Sus scrofa)
orc-4 [nucleoplasm]
(Caenorhabditis elegans)
Orc4 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001177811.1
,
NP_859525.1
,
XP_016859715.1
,
NP_001177810.1
,
XP_016859716.1
,
NP_859526.1
,
XP_011509557.1
,
NP_002543.2
,
NP_001177808.1
OpenTargets
ENSG00000115947
ENSEMBL
ENST00000264169
,
ENST00000540442
,
ENST00000535373
,
ENSP00000376597
,
ENST00000536575
,
ENST00000392857
,
ENSP00000264169
,
ENSP00000441502
,
ENSP00000438326
,
ENSP00000441953
HPA
ENSG00000115947-ORC4
PRO
O43929
Pharos - Targets
O43929
Orphanet
ORC4
PDB
7JPQ
,
5UJ7
,
7JPR
,
7JPS
,
7CTE
,
7CTF
,
7CTG
,
7JPO
,
7JPP
,
5UJM
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.813
12
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.737
8
UniProt:Q9Y5N6 ORC6
4
ORC6 [nucleoplasm]
(R-HSA-68539)
ORC6 [cytosol]
(R-HSA-9734663)
p-T195-ORC6 [cytosol]
(R-HSA-9734682)
p-T195-ORC6 [nucleoplasm]
(R-HSA-9734715)
0.607
2
UniProt:Q7LG56 RRM2B
1
RRM2B [cytosol]
(R-HSA-111792)
0.601
4
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.59
2
UniProt:Q9UBD5 ORC3
1
ORC3 [nucleoplasm]
(R-HSA-68513)
0.59
12
UniProt:Q8IV20 LACC1
0.589
2
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q92781 RDH5
6
RDH5 V177G [endoplasmic reticulum membrane]
(R-HSA-2471929)
RDH5 A294P [endoplasmic reticulum membrane]
(R-HSA-2471966)
RDH5 G238W [endoplasmic reticulum membrane]
(R-HSA-2471938)
RDH5 R157W [endoplasmic reticulum membrane]
(R-HSA-2471923)
RDH5 R280H [endoplasmic reticulum membrane]
(R-HSA-2471937)
RDH5 [endoplasmic reticulum membrane]
(R-HSA-74825)
0.488
2
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![ORC4 [nucleoplasm] icon](/icon/R-ICO-013134.svg){kind=icon}
