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EXOSC5 [cytosol]
Stable Identifier
R-HSA-429889
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Exosome complex exonuclease RRP46, EXOS5_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of IL-8 (Homo sapiens)
KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 3' to 5' exoribonuclease (Homo sapiens)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)
Exosome:SKI complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens)
BRF1 Complex recruits RNA degradation activities (Homo sapiens)
BRF1:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)
KSRP recruits RNA degradation activities (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Homo sapiens)
ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
TTP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQT4 EXOSC5
Gene Names
EXOSC5, CML28, RRP46
Chain
chain:1-235
Reference Genes
BioGPS Gene:56915 EXOSC5
COSMIC (genes):EXOSC5 EXOSC5
CTD Gene:56915 EXOSC5
dbSNP Gene:56915 EXOSC5
ENSEMBL:ENSG00000077348.10 EXOSC5
HGNC:24662 EXOSC5
KEGG Gene (Homo sapiens):56915 EXOSC5
Monarch:56915 EXOSC5
NCBI Gene:56915 EXOSC5
OMIM:606492 EXOSC5
UCSC:Q9NQT4 EXOSC5
Reference Transcript
RefSeq:NM_020158.3 EXOSC5
Other Identifiers
11716943_at
16872567
218481_PM_at
218481_at
3863061
3863062
3863063
3863065
3863066
3863068
3863070
3863071
3863072
3863073
53133_at
56915
8037023
A_24_P211151
GE62128
GO:0000175
GO:0000176
GO:0000177
GO:0000178
GO:0000791
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006364
GO:0006396
GO:0006401
GO:0016071
GO:0016073
GO:0016075
GO:0016787
GO:0034427
GO:0034475
GO:0042254
GO:0043226
GO:0043928
GO:0045006
GO:0051607
GO:0071028
GO:0071051
GO:0090503
GO:0098542
GO:0101019
GO:0140098
GO:1902494
HMNXSV003013768
ILMN_1659725
PH_hs_0014674
TC19001555.hg
g9910359_3p_at
Participates
as a component of
Exosome Ring Hexamer [cytosol] (Homo sapiens)
Other forms of this molecule
EXOSC5 [nucleoplasm]
Inferred To
rrp46 [cytosol]
(Schizosaccharomyces pombe)
Rrp46 [cytosol]
(Drosophila melanogaster)
exosc5 [cytosol]
(Xenopus tropicalis)
crn-5 [cytosol]
(Caenorhabditis elegans)
Exosc5 [cytosol]
(Mus musculus)
Exosc5 [cytosol]
(Rattus norvegicus)
EXOSC5 [cytosol]
(Bos taurus)
EXOSC5 [cytosol]
(Canis familiaris)
EXOSC5 [cytosol]
(Danio rerio)
EXOSC5 [cytosol]
(Dictyostelium discoideum)
EXOSC5 [cytosol]
(Gallus gallus)
EXOSC5 [cytosol]
(Sus scrofa)
RRP46 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_064543.3
OpenTargets
ENSG00000077348
HPA
ENSG00000077348-EXOSC5
GeneCards
Q9NQT4
Ensembl
ENSP00000221233
,
ENSG00000077348
,
ENST00000221233
PRO
Q9NQT4
Pharos - Targets
Q9NQT4
PDB
6D6Q
,
2NN6
,
6D6R
,
6H25
Interactors (65)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3B2 EXOSC1
2
EXOSC1 [nucleoplasm]
(R-HSA-6791578)
EXOSC1 [cytosol]
(R-HSA-429841)
0.972
33
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.939
22
UniProt:Q9NQT5 EXOSC3
2
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [cytosol]
(R-HSA-430017)
0.888
10
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.809
5
UniProt:Q8K3Y6 ZCCHV
0.806
6
UniProt:Q9UKT9 IKZF3
0.781
7
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.718
6
UniProt:Q9BYV2 TRI54
0.718
6
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.718
6
UniProt:O14526 FCHO1
1
FCHO1 [cytosol]
(R-HSA-8862257)
0.666
4
UniProt:Q15024 EXOSC7
2
EXOSC7 [nucleoplasm]
(R-HSA-6791543)
EXOSC7 [cytosol]
(R-HSA-430030)
0.643
3
UniProt:Q9NPD3 EXOSC4
2
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
EXOSC4 [cytosol]
(R-HSA-430013)
0.643
4
UniProt:Q8TF46 DI3L1
0.643
4
UniProt:Q13868 EXOSC2
2
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
EXOSC2 [cytosol]
(R-HSA-429999)
0.643
4
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.643
3
UniProt:A0A087WWI0 A0A087WWI0
0.556
3
UniProt:Q6ZSJ9 SHSA6
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q3KQV3 ZNF792
1
ZNF792 [nucleoplasm]
(R-HSA-3110242)
0.556
3
UniProt:Q13615 MTMR3
1
MTMR3 [cytosol]
(R-HSA-1604635)
0.556
3
UniProt:Q96GS4 BORC6
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q8NF50-2 DOCK8
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q8WZ19 KCTD13
1
KCTD13 [cytosol]
(R-HSA-9696533)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:Q13137 CACO2
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.556
3
IntAct:EBI-23324079 CCSB ORF ID
0.556
3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.556
3
UniProt:Q8TF47 ZFP90
1
ZFP90 [nucleoplasm]
(R-HSA-974988)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q9NQX0 PRDM6
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:O95447 LCA5L
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
UniProt:Q6ZUT1 NKAP1
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q8WXI4-2 Q8WXI42
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q8WY64 MYLIP
1
MYLIP [cytosol]
(R-HSA-8850908)
0.556
3
UniProt:A1A4E9 A1A4E9
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q86TG7-2 PEG10
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q8TAQ5 ZNF420
2
p-S68-ZNF420 [nucleoplasm]
(R-HSA-6799095)
ZNF420 [nucleoplasm]
(R-HSA-1247509)
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
5
IntAct:EBI-22620261 CCSB ORF ID
0.556
3
UniProt:P07954 FH
1
FH [mitochondrial matrix]
(R-HSA-70980)
0.556
3
UniProt:P02549 SPTA1
1
SPTA1 [cytosol]
(R-HSA-391563)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:Q5RKV6 EXOSC6
2
EXOSC6 [nucleoplasm]
(R-HSA-6791573)
EXOSC6 [cytosol]
(R-HSA-429921)
0.527
2
UniProt:P0DTD1-PRO_0000449626 REP
0.527
2
UniProt:Q9Y580 RBM7
1
RBM7 [nucleoplasm]
(R-HSA-8985564)
0.527
2
UniProt:Q06265 EXOSC9
2
EXOSC9 [nucleoplasm]
(R-HSA-6791577)
EXOSC9 [cytosol]
(R-HSA-429984)
0.527
3
UniProt:P42285 MTREX
1
SKIV2L2 [nucleoplasm]
(R-HSA-6791189)
0.527
2
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