Reactome | EXOSC5 [cytosol]

EXOSC5 [cytosol]

Stable Identifier

R-HSA-429889

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Exosome complex exonuclease RRP46, EXOS5_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        Exosome Complex [cytosol] (Homo sapiens)
        
        Exosome Ring Hexamer [cytosol] (Homo sapiens)
        
        EXOSC5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NQT4 EXOSC5

Gene Names

EXOSC5, CML28, RRP46

Chain

chain:1-235

Reference Genes

BioGPS Gene:56915 EXOSC5

COSMIC (genes):EXOSC5 EXOSC5

CTD Gene:56915 EXOSC5

dbSNP Gene:56915 EXOSC5

ENSEMBL:ENSG00000077348 EXOSC5

HGNC:24662 EXOSC5

KEGG:hsa:56915 EXOSC5

Monarch:56915 EXOSC5

NCBI Gene:56915 EXOSC5

OMIM:606492 EXOSC5

UCSC:Q9NQT4 EXOSC5

Reference Transcript

RefSeq:NM_020158.3 EXOSC5

Other Identifiers

11716943_at

16872567

218481_PM_at

218481_at

3863061

3863062

3863063

3863064

3863065

3863066

3863067

3863068

3863069

3863070

3863071

3863072

3863073

3863074

53133_at

56915

8037023

A_24_P211151

GE62128

GO:0000175

GO:0000176

GO:0000177

GO:0000178

GO:0000791

GO:0000956

GO:0003677

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006396

GO:0006401

GO:0006402

GO:0016071

GO:0016073

GO:0016075

GO:0016787

GO:0034475

GO:0043226

GO:0045006

GO:0051607

GO:0071028

GO:0071051

GO:0098542

GO:0101019

GO:0140098

GO:1902494

HMNXSV003013768

ILMN_1659725

PH_hs_0014674

TC19001555.hg

g9910359_3p_at

Participates

as a component of

Exosome Ring Hexamer [cytosol] (Homo sapiens)

Other forms of this molecule

EXOSC5 [nucleoplasm]

EXOSC5 [nucleolus]

Inferred To

rrp46 [cytosol] (Schizosaccharomyces pombe)

Rrp46 [cytosol] (Drosophila melanogaster)

exosc5 [cytosol] (Xenopus tropicalis)

crn-5 [cytosol] (Caenorhabditis elegans)

Exosc5 [cytosol] (Mus musculus)

Exosc5 [cytosol] (Rattus norvegicus)

EXOSC5 [cytosol] (Bos taurus)

EXOSC5 [cytosol] (Canis familiaris)

EXOSC5 [cytosol] (Dictyostelium discoideum)

EXOSC5 [cytosol] (Gallus gallus)

EXOSC5 [cytosol] (Sus scrofa)

RRP46 [cytosol] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000077348

ENSEMBL

ENSG00000077348, ENST00000221233, ENSP00000221233

GeneCards

EXOSC5

HPA

ENSG00000077348-EXOSC5

PRO

Q9NQT4

Pharos - Targets

Q9NQT4

GlyGen

Q9NQT4

PDB

6H25, 6D6Q, 6D6R, 2NN6, 9G8M

Interactors (76)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3B2 EXOSC1	3	EXOSC1 [nucleolus] (R-HSA-9935836) EXOSC1 [nucleoplasm] (R-HSA-6791578) EXOSC1 [cytosol] (R-HSA-429841)	0.973	35
UniProt:Q96B26 EXOSC8	3	EXOSC8 [nucleolus] (R-HSA-9935805) EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.948	25
UniProt:Q9NQT5 EXOSC3	3	EXOSC3 [nucleolus] (R-HSA-9935842) EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.901	12
UniProt:Q01780 EXOSC10	2	EXOSC10 [nucleoplasm] (R-HSA-6791547) EXOSC10 [nucleolus] (R-HSA-9935809)	0.886	8
UniProt:Q8K3Y6 ZCCHV			0.806	6
UniProt:Q9UKT9 IKZF3			0.781	7
UniProt:Q13901 C1D	2	C1D [nucleoplasm] (R-HSA-6791515) C1D [nucleolus] (R-HSA-9935822)	0.725	5
UniProt:Q15024 EXOSC7	3	EXOSC7 [nucleolus] (R-HSA-9935779) EXOSC7 [nucleoplasm] (R-HSA-6791543) EXOSC7 [cytosol] (R-HSA-430030)	0.725	5
UniProt:Q9NPD3 EXOSC4	3	EXOSC4 [nucleolus] (R-HSA-9935803) EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.725	6
UniProt:Q8TF46 DI3L1			0.725	6
UniProt:Q13868 EXOSC2	3	EXOSC2 [nucleolus] (R-HSA-9935794) EXOSC2 [nucleoplasm] (R-HSA-6791582) EXOSC2 [cytosol] (R-HSA-429999)	0.725	6
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.725	5
UniProt:Q9BYV2 TRI54			0.718	6
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.718	6
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.718	6
UniProt:O14526 FCHO1	1	FCHO1 [cytosol] (R-HSA-8862257)	0.666	4
UniProt:P07954 FH	1	FH [mitochondrial matrix] (R-HSA-70980)	0.659	4
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.659	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.659	4
UniProt:P42285 SKIV2L2	2	SKIV2L2 [nucleoplasm] (R-HSA-6791189) MTREX [nucleolus] (R-HSA-9935826)	0.643	4
UniProt:Q06265 EXOSC9	3	EXOSC9 [nucleolus] (R-HSA-9935807) EXOSC9 [nucleoplasm] (R-HSA-6791577) EXOSC9 [cytosol] (R-HSA-429984)	0.643	5
UniProt:Q5RKV6 EXOSC6	3	EXOSC6 [nucleolus] (R-HSA-9935802) EXOSC6 [nucleoplasm] (R-HSA-6791573) EXOSC6 [cytosol] (R-HSA-429921)	0.643	4
UniProt:Q99547 MPHOSPH6	2	MPHOSPH6 [nucleolus] (R-HSA-9935781) MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.615	5
UniProt:Q9Y450 HBS1L	1	HBS1L [cytosol] (R-HSA-8931539)	0.615	4
UniProt:A0A087WWI0 A0A087WWI0			0.556	3
UniProt:Q6ZSJ9 SHSA6			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.556	3
UniProt:Q13615 MTMR3	1	MTMR3 [cytosol] (R-HSA-1604635)	0.556	3
UniProt:Q96GS4 BORC6			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q8NF50-2 DOCK8			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q8WZ19 KCTD13	1	KCTD13 [cytosol] (R-HSA-9696533)	0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
IntAct:EBI-23324079 CCSB ORF ID			0.556	3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:O95447 LCA5L			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q8WY64 MYLIP	1	MYLIP [cytosol] (R-HSA-8850908)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
IntAct:EBI-22620261 CCSB ORF ID			0.556	3
UniProt:P02549 SPTA1	1	SPTA1 [cytosol] (R-HSA-391563)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	5
UniProt:Q8TAQ5 ZNF420	2	p-S68-ZNF420 [nucleoplasm] (R-HSA-6799095) ZNF420 [nucleoplasm] (R-HSA-1247509)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q86TG7-2 PEG10			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q8WXI4-2 Q8WXI42			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.536	2
UniProt:Q8IWA0 WDR75	1	WDR75 [nucleoplasm] (R-HSA-6790666)	0.527	2
UniProt:P0DTD1-PRO_0000449626 REP			0.527	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	2
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.527	3
UniProt:Q6Y7W6 GGYF2			0.527	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [azurophil granule lumen] (R-HSA-6799205) PA2G4 [extracellular region] (R-HSA-6806200)	0.519	2
UniProt:Q9UDY2 TJP2	4	TJP2 [plasma membrane] (R-HSA-351862) TJP2(?-?) [plasma membrane] (R-HSA-351897) TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410)	0.483	2
UniProt:Q8WXF1 PSPC1			0.483	2

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