Reactome | EXOSC9 [cytosol]

EXOSC9 [cytosol]

Stable Identifier

R-HSA-429984

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EXOSC9 (RRP45), Exosome complex exonuclease RRP45, EXOS9_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        Exosome Complex [cytosol] (Homo sapiens)
        
        Exosome Ring Hexamer [cytosol] (Homo sapiens)
        
        EXOSC9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q06265 EXOSC9

Gene Names

EXOSC9, PMSCL1

Chain

chain:1-439

Reference Genes

BioGPS Gene:5393 EXOSC9

COSMIC (genes):EXOSC9 EXOSC9

CTD Gene:5393 EXOSC9

dbSNP Gene:5393 EXOSC9

ENSEMBL:ENSG00000123737 EXOSC9

ENSEMBL_homo_sapiens_GENE:ENSG00000123737.13 EXOSC9

HGNC:9137 EXOSC9

KEGG Gene (Homo sapiens):5393 EXOSC9

Monarch:5393 EXOSC9

NCBI Gene:5393 EXOSC9

OMIM:606180 EXOSC9

UCSC:Q06265 EXOSC9

Reference Transcript

Other Identifiers

11726371_a_at

11743004_x_at

11753011_a_at

16970231

205061_PM_s_at

205061_s_at

2741769

2741770

2741773

2741774

2741775

2741776

2741778

2741779

2741781

2741782

2741783

2741784

2741786

2741788

2741790

2741792

2741793

2741794

2741795

5393

63921_at

8097128

A_23_P81121

GO:0000175

GO:0000176

GO:0000177

GO:0000178

GO:0000228

GO:0000467

GO:0000956

GO:0002376

GO:0003723

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006364

GO:0006396

GO:0006399

GO:0006401

GO:0006955

GO:0016071

GO:0016073

GO:0016787

GO:0030307

GO:0034427

GO:0034473

GO:0034475

GO:0034476

GO:0035925

GO:0042254

GO:0043226

GO:0043928

GO:0045944

GO:0061629

GO:0070062

GO:0071028

GO:0071035

GO:0071038

GO:0071042

GO:0101019

GO:0140098

GO:1902494

HMNXSV003047076

ILMN_1721713

ILMN_2312719

M58460_at

PH_hs_0005095

TC04000625.hg

g4826921_3p_a_at

Participates

as a component of

Exosome Ring Hexamer [cytosol] (Homo sapiens)

Other forms of this molecule

EXOSC9 [nucleoplasm]

Inferred To

exosc9 [cytosol] (Xenopus tropicalis)

exos-9 [cytosol] (Caenorhabditis elegans)

Rrp45 [cytosol] (Drosophila melanogaster)

RRP45 [cytosol] (Saccharomyces cerevisiae)

EXOSC9 [cytosol] (Bos taurus)

EXOSC9 [cytosol] (Canis familiaris)

EXOSC9 [cytosol] (Dictyostelium discoideum)

EXOSC9 [cytosol] (Gallus gallus)

EXOSC9 [cytosol] (Sus scrofa)

rrp45 [cytosol] (Schizosaccharomyces pombe)

Exosc9 [cytosol] (Mus musculus)

Exosc9 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_005024.2, NP_001029366.1

OpenTargets

ENSG00000123737

HPA

ENSG00000123737-EXOSC9

GeneCards

Q06265

Ensembl

ENST00000379663, ENSG00000123737, ENST00000243498, ENSP00000243498, ENSP00000368984

PRO

Q06265

Pharos - Targets

Q06265

Orphanet

27313

PDB

6D6Q, 6H25, 2NN6, 6D6R

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.643	3
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.643	5
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.553	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.527	2