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WDR75 [nucleoplasm]
Stable Identifier
R-HSA-6790666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WD repeat-containing protein 75, WDR75_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
18SE pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
47S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPA complex [nucleoplasm] (Homo sapiens)
WDR75 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWA0 WDR75
Gene Names
WDR75, UTP17
Chain
chain:1-830
Reference Genes
BioGPS Gene:84128 WDR75
COSMIC (genes):WDR75 WDR75
CTD Gene:84128 WDR75
dbSNP Gene:84128 WDR75
ENSEMBL:ENSG00000115368 WDR75
HGNC:25725 WDR75
Monarch:84128 WDR75
NCBI Gene:84128 WDR75
OMIM:620341 WDR75
UCSC:Q8IWA0 WDR75
Reference Transcript
RefSeq:NM_032168.2 WDR75
RefSeq:NM_001303096.1 WDR75
Other Identifiers
11717308_a_at
11717309_x_at
16888674
224721_PM_at
224721_at
2519758
2519759
2519765
2519766
2519767
2519768
2519769
2519770
2519771
2519772
2519776
2519777
2519778
2519779
2519784
2519785
2519788
2519789
2519792
2519793
2519794
2519795
2519796
2519797
2519798
2519799
2519800
2519801
2519805
2519808
2519811
2519813
2519818
2519821
2519823
2519824
2519830
2519832
57078_at
8046975
84128
A_14_P139206
A_32_P217510
GE62923
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006355
GO:0006364
GO:0032040
GO:0042254
GO:0042274
GO:0043226
GO:0045943
GO:2000234
HMNXSV003001240
Hs.182669.0.S1_3p_at
ILMN_1801869
PH_hs_0024601
TC02001108.hg
Participates
as a component of
UTPA complex [nucleoplasm] (Homo sapiens)
Inferred To
NAN1 [nucleoplasm]
(Saccharomyces cerevisiae)
utp17 [nucleoplasm]
(Schizosaccharomyces pombe)
Wdr75 [nucleoplasm]
(Mus musculus)
Wdr75 [nucleoplasm]
(Rattus norvegicus)
wdr75 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of WDR75 [nucleoplasm]
(Plasmodium falciparum)
l(2)05287 [nucleoplasm]
(Drosophila melanogaster)
WDR75 [nucleoplasm]
(Bos taurus)
WDR75 [nucleoplasm]
(Caenorhabditis elegans)
WDR75 [nucleoplasm]
(Canis familiaris)
WDR75 [nucleoplasm]
(Gallus gallus)
WDR75 [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000314761
,
ENSP00000314193
OpenTargets
ENSG00000115368
HPA
ENSG00000115368-WDR75
PRO
Q8IWA0
Pharos - Targets
Q8IWA0
GlyGen
Q8IWA0
PDB
7MQA
,
7MQ9
,
7MQ8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.527
2
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.527
2
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