Reactome | TRIB3 [cytosol]

TRIB3 [cytosol]

Stable Identifier

R-HSA-162411

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRB-3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        AKT2 binds PIP3 (Homo sapiens)
        
        AKT2:THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        TRIB3 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        TRIB3 [cytosol] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        AKT2 binds PIP3 (Homo sapiens)
        
        AKT2:THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        TRIB3 [cytosol] (Homo sapiens)
        
        THEM4,TRIB3 [cytosol] (Homo sapiens)
        
        TRIB3 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12791994	TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Kulkarni, RN, Herzig, S, Du, K, Montminy, M	Science	2003

External Reference Information

External Reference

UniProt:Q96RU7 TRIB3

Gene Names

TRIB3, C20orf97, NIPK, SKIP3, TRB3

Chain

chain:1-358

Reference Genes

BioGPS Gene:57761 TRIB3

COSMIC (genes):TRIB3 TRIB3

CTD Gene:57761 TRIB3

dbSNP Gene:57761 TRIB3

ENSEMBL:ENSG00000101255 TRIB3

ENSEMBL_homo_sapiens_GENE:ENSG00000101255.12 TRIB3

HGNC:16228 TRIB3

KEGG Gene (Homo sapiens):57761 TRIB3

Monarch:57761 TRIB3

NCBI Gene:57761 TRIB3

OMIM:607898 TRIB3

UCSC:Q96RU7 TRIB3

Reference Transcript

Other Identifiers

11719811_a_at

11751172_a_at

1555788_PM_a_at

1555788_a_at

16910609

218145_PM_at

218145_at

3873165

3873166

3873167

3873168

3873172

3873173

3873174

3873175

3873176

3873177

3873178

3873179

3873180

3873181

3873182

51141_at

57761

8060344

83485_at

A_23_P210690

A_24_P305541

GE82597

GO:0000122

GO:0003714

GO:0003824

GO:0004672

GO:0004860

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006469

GO:0006629

GO:0006914

GO:0006915

GO:0010506

GO:0010827

GO:0012501

GO:0016740

GO:0019899

GO:0019901

GO:0023052

GO:0030154

GO:0030163

GO:0031434

GO:0031625

GO:0032092

GO:0032436

GO:0032869

GO:0034976

GO:0036211

GO:0043226

GO:0043405

GO:0045599

GO:0045717

GO:0045892

GO:0051443

GO:0055085

GO:0055106

GO:0070059

GO:0098772

GO:0140096

GO:0140110

HMNXSV003014913

Hs2.26802.3.S1_3p_s_at

ILMN_1787815

PH_hs_0023894

TC20000009.hg

g11056039_3p_at

Participates

as a member of

THEM4,TRIB3 [cytosol] (Homo sapiens)

Other forms of this molecule

TRIB3 [plasma membrane]

TRIB3 [nucleoplasm]

Inferred To

trbl [cytosol] (Drosophila melanogaster)

Trib3 [cytosol] (Mus musculus)

Trib3 [cytosol] (Rattus norvegicus)

TRIB3 [cytosol] (Bos taurus)

TRIB3 [cytosol] (Caenorhabditis elegans)

TRIB3 [cytosol] (Sus scrofa)

trib3 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001288125.1, NP_001288130.1, NP_001288117.1, NP_066981.2, NP_001288119.1, NP_001288122.1

Guide to Pharmacology - Targets

2251

OpenTargets

ENSG00000101255

HPA

ENSG00000101255-TRIB3

GeneCards

Q96RU7

Ensembl

ENSP00000217233, ENST00000217233, ENSG00000101255

PRO

Q96RU7

Pharos - Targets

Q96RU7

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.9	16
UniProt:Q9NRW3 APOBEC3C	1	APOBEC3C [nucleoplasm] (R-HSA-8874997)	0.666	7
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.666	4
UniProt:Q8N2I9 STK40			0.643	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.61	4
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q96KN7 RPGR1			0.556	3
UniProt:Q0VAL7 Q0VAL7			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q9BRU9 UTP23			0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q96NU1 SAM11			0.556	3
UniProt:Q8IVT2 MISP			0.556	3
IntAct:EBI-22315148 CCSB ORF ID			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:O15197-2 EPHB6			0.556	3
UniProt:Q9Y242 TCF19			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:O14929 HAT1	1	HAT1 [nucleoplasm] (R-HSA-3662337)	0.556	3
UniProt:Q7Z3Y9 KRT26	1	KRT26 [cytosol] (R-HSA-6809593)	0.556	3
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q5T8A7 PPR26			0.556	3
UniProt:Q6P5X5 CV039			0.556	3
UniProt:Q96KN7-4 RPGRIP1			0.556	3
UniProt:Q99697-2 PITX2			0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:P78358 CTG1B			0.556	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.556	3
UniProt:Q9H6L4 ARMC7			0.556	3
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q6NZ36-4 FAAP20			0.556	3
UniProt:Q9NWQ4-1 GPATCH2L			0.556	3
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.556	3
UniProt:Q9BXF9 TEKT3			0.556	3
UniProt:P51800-3 CLCNKA			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:P56524-2 HDAC4			0.556	3
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:Q92824-2 PCSK5			0.556	3
UniProt:A6NJB7-2 PRR19			0.556	3
UniProt:Q13111 CAF1A			0.556	5
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:Q8WUN7 UBTD2			0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:Q8WW24 TEKT4			0.556	5
UniProt:Q63ZY3 KANK2			0.556	5
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q9UM07 PADI4	2	PADI4 [cytosol] (R-HSA-1183117) PADI4 [nucleoplasm] (R-HSA-6793448)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q8NEA6-2 GLIS3			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q9NUL5-4 SHFL			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q2WGJ6 KLH38			0.556	3
UniProt:P78412 IRX6			0.556	3
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [nucleoplasm] (R-HSA-349450) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [cytosol] (R-HSA-349439)	0.527	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.508	2

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