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MyrG-CDK5R1(2-98) [plasma membrane]
Stable Identifier
R-HSA-8863400
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Calpain cleaves p35 to p25 (Homo sapiens)
MyrG-CDK5R1(2-98) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15078 CDK5R1
Gene Names
CDK5R1, CDK5R, NCK5A
Chain
initiator methionine:1, chain:2-307, chain:99-307
Reference Genes
BioGPS Gene:8851 CDK5R1
COSMIC (genes):CDK5R1 CDK5R1
CTD Gene:8851 CDK5R1
dbSNP Gene:8851 CDK5R1
ENSEMBL:ENSG00000176749 CDK5R1
ENSEMBL_homo_sapiens_GENE:ENSG00000176749 CDK5R1
HGNC:1775 CDK5R1
KEGG Gene (Homo sapiens):8851 CDK5R1
Monarch:8851 CDK5R1
NCBI Gene:8851 CDK5R1
OMIM:603460 CDK5R1
UCSC:Q15078 CDK5R1
Reference Transcript
RefSeq:XM_017025281.1 CDK5R1
RefSeq:XM_011525438.2 CDK5R1
RefSeq:NM_003885.2 CDK5R1
Other Identifiers
0002060736
11722022_s_at
16833159
1H4L
1UNG
1UNH
1UNL
204995_at
204996_s_at
252
36273_at
3717776
3717777
3717780
3717781
3717782
3717783
3717784
3717785
3717786
3O0G
55644_at
799_at
8006409
800_g_at
8851
A_14_P109471
A_14_P116589
A_14_P125186
A_23_P141467
A_33_P3226985
AAH20580
AAQ74776
AAV38380
AY376350
BC020580
BT019573
CAA56587
CCDS11273
CDK5R1
CDK5R1-201
CH471147
EAW80227
EAW80228
ENSG00000176749
ENSP00000318486
ENST00000313401
EntrezGene:8851
g4502736_3p_a_at
GE60061
GO:0000079
GO:0000226
GO:0000902
GO:0001764
GO:0002020
GO:0003674
GO:0003779
GO:0004672
GO:0005509
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006464
GO:0006605
GO:0006810
GO:0006914
GO:0007010
GO:0007049
GO:0007155
GO:0007158
GO:0007165
GO:0007213
GO:0007411
GO:0007413
GO:0007420
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0009790
GO:0009792
GO:0014069
GO:0016020
GO:0016241
GO:0016301
GO:0016533
GO:0016534
GO:0018105
GO:0018107
GO:0019899
GO:0019901
GO:0021549
GO:0021700
GO:0021722
GO:0021766
GO:0021799
GO:0021819
GO:0022607
GO:0030154
GO:0030182
GO:0030234
GO:0030424
GO:0030425
GO:0030426
GO:0030517
GO:0031116
GO:0031175
GO:0031594
GO:0032956
GO:0032991
GO:0034641
GO:0035235
GO:0035255
GO:0040007
GO:0040011
GO:0042501
GO:0043005
GO:0043014
GO:0043025
GO:0043167
GO:0043197
GO:0043226
GO:0043231
GO:0043292
GO:0043525
GO:0043539
GO:0045296
GO:0045664
GO:0045860
GO:0045892
GO:0046875
GO:0048013
GO:0048471
GO:0048487
GO:0048511
GO:0048646
GO:0048856
GO:0048870
GO:0051015
GO:0061001
GO:0065003
GO:0070507
GO:0071158
GO:0071902
GO:0090314
GO:0098693
GO:0098793
HGNC:1775
HPA000252
Hs.93597.0.S2_3p_at
ILMN_1730928
ILMN_2062271
IPR004944
IPR036915
MIM:603460
NM_003885
NP_003876
PF03261
PH_hs_0005140
TC17000377.hg
uc002hhn.4
UPI000012738E
X80343
X80343_at
XM_011525438
XM_017025281
XP_011523740
XP_016880770
Participant Of
output
Calpain cleaves p35 to p25
Other forms of this molecule
CDK5R1(99-307) [cytosol]
MyrG-CDK5R1(2-307) [plasma membrane]
CDK5R1(99-307) [nucleoplasm]
Modified Residues
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
XP_011523740.1
,
XP_016880770.1
,
NP_003876.1
OpenTargets
ENSG00000176749
ZINC - Substances
CD5R1_HUMAN
GeneCards
Q15078
DOCK Blaster
3O0G
,
1H4L
,
1UNH
,
1UNG
,
1UNL
ZINC target
Q15078
PRO
Q15078
ZINC - Predictions - Purchasable
CD5R1_HUMAN
PDB
1UNG
,
1UNL
,
1UNH
,
1H4L
,
3O0G
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00535 CDK5
4
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
0.872
11
UniProt:Q6ZMQ8-2 AATK
0.593
6
UniProt:Q5JR59 MTUS2
0.556
3
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