SUMOylation of PIAS4 with SUMO1

Stable Identifier
R-HSA-3968362
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of PIAS4 with SUMO1
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PIAS4 is SUMOylated at lysine-35 with SUMO1 (Ihara et al. 2005). SUMOylation of PIAS4 at lysine-35 decreases its localization with PML. SUMOylated PIAS4 is able to increase SUMOylation and transcriptional activity of TCF4.
Literature References
PubMed ID Title Journal Year
15831457 SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4

Kikuchi, A, Ihara, M, Yamamoto, H

Mol. Cell. Biol. 2005
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of PIAS4 with SUMO1 (Bos taurus)
SUMOylation of PIAS4 with SUMO1 (Caenorhabditis elegans)
SUMOylation of PIAS4 with SUMO1 (Danio rerio)
SUMOylation of PIAS4 with SUMO1 (Gallus gallus)
SUMOylation of PIAS4 with SUMO1 (Mus musculus)
SUMOylation of PIAS4 with SUMO1 (Rattus norvegicus)
SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)
SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)
SUMOylation of PIAS4 with SUMO1 (Sus scrofa)
SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-07-21)
Reviewed
Niskanen, E  (2018-06-09)
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-23)
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