SUMOylation of PIAS4 with SUMO1

Stable Identifier
R-HSA-3968362
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS4 is SUMOylated at lysine-35 with SUMO1 (Ihara et al. 2005). SUMOylation of PIAS4 at lysine-35 decreases its localization with PML. SUMOylated PIAS4 is able to increase SUMOylation and transcriptional activity of TCF4.

Literature References
PubMed ID Title Journal Year
15831457 SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4

Ihara, M, Yamamoto, H, Kikuchi, A

Mol. Cell. Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created