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LPIN1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-549157
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
lipin 1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
LPIN1 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
LPIN1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PC (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
LPIN [endoplasmic reticulum membrane] (Homo sapiens)
LPIN1:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)
LPIN1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of PE (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
LPIN [endoplasmic reticulum membrane] (Homo sapiens)
LPIN1:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)
LPIN1 [endoplasmic reticulum membrane] (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride biosynthesis (Homo sapiens)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)
LPIN1,2,3 [endoplasmic reticulum membrane] (Homo sapiens)
LPIN1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14693 LPIN1
Gene Names
LPIN1, KIAA0188
Chain
chain:1-890
Reference Genes
BioGPS Gene:23175 LPIN1
COSMIC (genes):LPIN1 LPIN1
CTD Gene:23175 LPIN1
dbSNP Gene:23175 LPIN1
ENSEMBL:ENSG00000134324 LPIN1
ENSEMBL_homo_sapiens_GENE:ENSG00000134324.12 LPIN1
HGNC:13345 LPIN1
KEGG Gene (Homo sapiens):23175 LPIN1
Monarch:23175 LPIN1
NCBI Gene:23175 LPIN1
OMIM:605518 LPIN1
UCSC:Q14693 LPIN1
Reference Transcript
RefSeq:NM_001261427.1 LPIN1
RefSeq:NM_001261428.1 LPIN1
RefSeq:XM_006711872.2 LPIN1
RefSeq:XM_006711874.2 LPIN1
RefSeq:XM_017003625.1 LPIN1
RefSeq:XM_017003628.1 LPIN1
RefSeq:NM_001261429.1 LPIN1
RefSeq:NM_145693.2 LPIN1
RefSeq:XM_011510334.2 LPIN1
RefSeq:XM_011510335.2 LPIN1
RefSeq:XM_017003629.1 LPIN1
RefSeq:XM_017003630.1 LPIN1
RefSeq:XM_006711870.3 LPIN1
RefSeq:XM_006711871.2 LPIN1
RefSeq:XM_011510336.2 LPIN1
RefSeq:XM_017003624.1 LPIN1
Other Identifiers
11750566_a_at
11754573_a_at
11757747_s_at
16877225
212272_PM_at
212272_at
212274_PM_at
212274_at
212276_PM_at
212276_at
23175
2469907
2469927
2469930
2469932
2469935
2469939
2469941
2469944
2469945
2469946
2469948
2469950
2469954
2469955
2469956
2469958
2469961
2469962
2469964
2469965
2469967
2469972
2469973
2469974
2469977
2469980
2469982
2469985
2469986
2469987
2469988
38098_at
8040340
A_14_P200760
A_14_P202397
A_32_P52609
A_33_P3356070
A_33_P3356075
D80010_at
GE57317
GO:0000278
GO:0003713
GO:0003824
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005829
GO:0006260
GO:0006351
GO:0006355
GO:0006629
GO:0006631
GO:0006642
GO:0006654
GO:0007077
GO:0008195
GO:0009062
GO:0016020
GO:0016787
GO:0019432
GO:0031100
GO:0031642
GO:0031965
GO:0032869
GO:0043226
GO:0045740
GO:0045944
GO:0046473
GO:0048856
GO:0050877
GO:0061024
GO:0120162
GO:0140110
HMNXSV003003375
HMNXSV003055058
Hs.81412.0.A1_3p_at
Hs.81412.0.A2_3p_at
Hs.81412.0.A3_3p_at
ILMN_1671554
PH_hs_0004665
PH_hs_0031361
TC02000078.hg
Participates
as a member of
LPIN1,2,3 [endoplasmic reticulum membrane] (Homo sapiens)
as an output of
LPIN1 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
as a component of
LPIN1:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
p-S106-LPIN1 [nucleoplasm]
LPIN1 [nuclear envelope]
Inferred To
lpin-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
LPIN1 [endoplasmic reticulum membrane]
(Bos taurus)
LPIN1 [endoplasmic reticulum membrane]
(Canis familiaris)
LPIN1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
LPIN1 [endoplasmic reticulum membrane]
(Gallus gallus)
LPIN1 [endoplasmic reticulum membrane]
(Plasmodium falciparum)
LPIN1 [endoplasmic reticulum membrane]
(Sus scrofa)
PAH1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
lpin1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Lpin1 [endoplasmic reticulum membrane]
(Mus musculus)
Lpin1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
ned1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
Lpin [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011508637.1
,
XP_006711933.1
,
XP_016859118.1
,
XP_016859117.1
,
NP_001248358.1
,
XP_006711937.1
,
XP_016859113.1
,
NP_001248357.1
,
XP_011508638.1
,
NP_663731.1
,
XP_006711934.1
,
XP_016859119.1
,
XP_006711935.1
,
XP_016859114.1
,
XP_011508636.1
,
NP_001248356.1
Guide to Pharmacology - Targets
1435
OpenTargets
ENSG00000134324
IntEnz
3.1.3.4
GeneCards
Q14693
HPA
ENSG00000134324-LPIN1
Ensembl
ENSG00000134324
,
ENSP00000256720
,
ENSP00000401522
,
ENST00000449576
,
ENSP00000379404
,
ENSP00000397908
,
ENSP00000379405
,
ENST00000425416
,
ENSP00000501331
,
ENST00000256720
,
ENST00000396097
,
ENST00000674199
,
ENST00000396098
PRO
Q14693
Pharos - Targets
Q14693
Orphanet
17883
HMDB Protein
HMDBP11805
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q01658 DR1
1
DR1 [nucleoplasm]
(R-HSA-3662280)
0.556
3
UniProt:P21333-2 FLNA
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P09172 DBH
1
DBH(40-617) [secretory granule lumen]
(R-HSA-209790)
0.556
3
UniProt:Q9UBB4 ATX10
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q9Y5Q9 GTF3C3
1
GTF3C3 [nucleoplasm]
(R-HSA-83691)
0.556
3
UniProt:P50440 GATM
1
GATM [mitochondrial intermembrane space]
(R-HSA-71267)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q00613 HSF1
11
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
HSF1 [cytosol]
(R-HSA-3371452)
0.556
3
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.556
3
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.556
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:Q9BQK8 LPIN3
3
p-S106-LPIN3 [nucleoplasm]
(R-HSA-4419935)
LPIN3 [nuclear envelope]
(R-HSA-4419928)
LPIN3 [endoplasmic reticulum membrane]
(R-HSA-549160)
0.527
3
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