Reactome | LPIN1 [endoplasmic reticulum membrane]

LPIN1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-549157

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

lipin 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14693 LPIN1

Gene Names

LPIN1, KIAA0188

Chain

chain:1-890

Reference Genes

BioGPS Gene:23175 LPIN1

COSMIC (genes):LPIN1 LPIN1

CTD Gene:23175 LPIN1

dbSNP Gene:23175 LPIN1

ENSEMBL:ENSG00000134324 LPIN1

ENSEMBL:ENSG00000134324.12 LPIN1

HGNC:13345 LPIN1

KEGG Gene (Homo sapiens):23175 LPIN1

Monarch:23175 LPIN1

NCBI Gene:23175 LPIN1

OMIM:605518 LPIN1

UCSC:Q14693 LPIN1

Reference Transcript

Other Identifiers

11750566_a_at

11754573_a_at

11757747_s_at

16877225

212272_PM_at

212272_at

212274_PM_at

212274_at

212276_PM_at

212276_at

23175

2469907

2469927

2469930

2469932

2469935

2469939

2469941

2469944

2469945

2469946

2469948

2469950

2469954

2469955

2469956

2469958

2469961

2469962

2469964

2469965

2469967

2469972

2469973

2469974

2469977

2469980

2469982

2469985

2469986

2469987

2469988

38098_at

8040340

A_14_P200760

A_14_P202397

A_32_P52609

A_33_P3356070

A_33_P3356075

D80010_at

GE57317

GO:0000278

GO:0003713

GO:0003824

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005783

GO:0005789

GO:0005829

GO:0006260

GO:0006351

GO:0006355

GO:0006629

GO:0006631

GO:0006642

GO:0006654

GO:0007077

GO:0008195

GO:0009062

GO:0016020

GO:0016787

GO:0019432

GO:0031100

GO:0031642

GO:0031965

GO:0032869

GO:0043226

GO:0045740

GO:0045944

GO:0046473

GO:0048856

GO:0050877

GO:0061024

GO:0120162

GO:0140110

GO:1903741

HMNXSV003003375

HMNXSV003055058

Hs.81412.0.A1_3p_at

Hs.81412.0.A2_3p_at

Hs.81412.0.A3_3p_at

ILMN_1671554

PH_hs_0004665

PH_hs_0031361

TC02000078.hg

Participates

as a member of

LPIN1,2,3 [endoplasmic reticulum membrane] (Homo sapiens)

as a component of

LPIN1:Mg2+ [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

p-S106-LPIN1 [nucleoplasm]

LPIN1 [nuclear envelope]

Inferred To

lpin-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

LPIN1 [endoplasmic reticulum membrane] (Bos taurus)

LPIN1 [endoplasmic reticulum membrane] (Canis familiaris)

LPIN1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

LPIN1 [endoplasmic reticulum membrane] (Gallus gallus)

LPIN1 [endoplasmic reticulum membrane] (Plasmodium falciparum)

LPIN1 [endoplasmic reticulum membrane] (Sus scrofa)

PAH1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

lpin1 [endoplasmic reticulum membrane] (Danio rerio)

lpin1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Lpin1 [endoplasmic reticulum membrane] (Mus musculus)

Lpin1 [endoplasmic reticulum membrane] (Rattus norvegicus)

ned1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Lpin [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_006711935.1, XP_016859114.1, XP_006711937.1, NP_001248358.1, NP_663731.1, XP_016859113.1, NP_001248357.1, XP_006711933.1, XP_016859119.1, XP_011508637.1, NP_001248356.1, XP_011508636.1, XP_006711934.1, XP_016859118.1, XP_016859117.1, XP_011508638.1

Guide to Pharmacology - Targets

1435

OpenTargets

ENSG00000134324

IntEnz

3.1.3.4

GeneCards

Q14693

HPA

ENSG00000134324-LPIN1

Ensembl

ENSP00000397908, ENSG00000134324, ENST00000256720, ENST00000674199, ENSP00000501331, ENSP00000256720, ENSP00000401522, ENSP00000379405, ENST00000449576, ENSP00000379404, ENST00000396097, ENST00000396098, ENST00000425416

PRO

Q14693

Pharos - Targets

Q14693

Orphanet

17883

HMDB Protein

HMDBP11805

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) HSF1 [cytosol] (R-HSA-3371452)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12

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