Reactome | ESRRA [nucleoplasm]

ESRRA [nucleoplasm]

Stable Identifier

R-HSA-446159

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Steroid hormone receptor ERR1, ERR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P11474 ESRRA

Gene Names

ESRRA, ERR1, ESRL1, NR3B1

Chain

chain:1-423

Reference Genes

BioGPS Gene:2101 ESRRA

COSMIC (genes):ESRRA ESRRA

CTD Gene:2101 ESRRA

dbSNP Gene:2101 ESRRA

ENSEMBL:ENSG00000173153 ESRRA

HGNC:3471 ESRRA

KEGG:hsa:2101 ESRRA

Monarch:2101 ESRRA

NCBI Entrez Gene:2101 ESRRA

OMIM:601998 ESRRA

UCSC:P11474 ESRRA

Reference Transcript

Other Identifiers

11718526_a_at

11757487_x_at

1487_PM_at

1487_at

16726429

203193_PM_at

203193_at

2101

3334480

3334481

3334483

3334485

3334486

3334487

3334488

3334489

3334490

3334492

3334493

3334494

3334495

3334496

3334497

3334499

3334500

3480712

3480715

3480722

3480724

3480727

3480729

3480730

3503897

3503900

3503901

3503906

3503909

7940989

A_23_P1585

A_23_P202773

A_33_P3243544

GE59754

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001650

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005496

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0006355

GO:0006357

GO:0008270

GO:0008289

GO:0010468

GO:0015630

GO:0019904

GO:0030518

GO:0030522

GO:0034056

GO:0043565

GO:0045171

GO:0045944

GO:0046872

GO:1990837

HMNXSV003001770

HMNXSV003025442

ILMN_1774272

L38487_at

PH_hs_0005265

PH_hs_0031528

TC11000596.hg

g4758305_3p_s_at

g7705561_3p_at

Participates

as an output of

Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)

as a member of

NR [nucleoplasm] (Homo sapiens)

as a component of

This entity regulates

Positively

Inferred To

ESRRA [nucleoplasm] (Bos taurus)

ESRRA [nucleoplasm] (Canis familiaris)

ESRRA [nucleoplasm] (Sus scrofa)

Esrra [nucleoplasm] (Mus musculus)

Esrra [nucleoplasm] (Rattus norvegicus)

knrl [nucleoplasm] (Drosophila melanogaster)

esrra [nucleoplasm] (Xenopus tropicalis)

ERR [nucleoplasm] (Drosophila melanogaster)

kni [nucleoplasm] (Drosophila melanogaster)

Homologues of ESRRA [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001269379.1, NP_001269380.1, NP_004442.3

ZINC - World Drugs

ERR1_HUMAN

Guide to Pharmacology - Targets

622

OpenTargets

ENSG00000173153

ENSEMBL

ENSG00000173153, ENST00000000442, ENSP00000000442, ENST00000405666, ENST00000677967, ENSP00000503245, ENSP00000384851

ZINC - FDA approved

ERR1_HUMAN

ZINC - Substances

ERR1_HUMAN

ZINC - Biogenic

ERR1_HUMAN

ZINC target

P11474

PRO

P11474

PDB

1XB7, 2PJL, 3K6P, 7E2E, 3D24

ZINC - Investigational

ERR1_HUMAN

ZINC - Metabolites

ERR1_HUMAN

HPA

ENSG00000173153-ESRRA

GeneCards

ESRRA

Pharos - Targets

P11474

ZINC - Predictions - Purchasable

ERR1_HUMAN

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.894	20
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.576	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.573	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:P62508-3 ESRRG			0.556	3
UniProt:P48788 TNNI2	1	TNNI2 [cytosol] (R-HSA-390538)	0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
IntAct:EBI-20184588 DR0			0.544	5
IntAct:EBI-20185384 ERE			0.544	3
UniProt:P62508 ESRRG	1	ESRRG [nucleoplasm] (R-HSA-446166)	0.527	2
UniProt:P55854 SUMO3	5	SUMO3 [nucleoplasm] (R-HSA-2984269) UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611) lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm] (R-HSA-9761547) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627) SUMO3(1-103) [nucleoplasm] (R-HSA-2990830)	0.463	2

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