Reactome | ESRRA [nucleoplasm]

ESRRA [nucleoplasm]

Stable Identifier

R-HSA-446159

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Steroid hormone receptor ERR1, ERR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P11474 ESRRA

Gene Names

ESRRA, ERR1, ESRL1, NR3B1

Chain

chain:1-423

Reference Genes

BioGPS Gene:2101 ESRRA

COSMIC (genes):ESRRA ESRRA

CTD Gene:2101 ESRRA

dbSNP Gene:2101 ESRRA

ENSEMBL:ENSG00000173153 ESRRA

HGNC:3471 ESRRA

KEGG:hsa:2101 ESRRA

Monarch:2101 ESRRA

NCBI Gene:2101 ESRRA

OMIM:601998 ESRRA

UCSC:P11474 ESRRA

Reference Transcript

Other Identifiers

11718526_a_at

11757487_x_at

1487_PM_at

1487_at

16726429

203193_PM_at

203193_at

2101

3334483

3334485

3334486

3334487

3334488

3334490

3334492

3334493

3334494

3334495

3334496

3334497

3334499

3334500

3480715

3480722

3480724

3480727

3480729

3480730

3503897

3503900

3503901

3503906

3503909

7940989

A_23_P1585

A_33_P3243544

GE59754

GO:0000785

GO:0000981

GO:0001650

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005496

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0006355

GO:0006357

GO:0008270

GO:0008289

GO:0015630

GO:0019904

GO:0030518

GO:0034056

GO:0043226

GO:0043401

GO:0043565

GO:0045171

GO:0045944

GO:0046872

GO:0060089

GO:0140110

GO:1990837

HMNXSV003001770

ILMN_1774272

L38487_at

PH_hs_0031528

TC11000596.hg

g4758305_3p_s_at

Participates

as an output of

Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)

as a member of

NR [nucleoplasm] (Homo sapiens)

as a component of

This entity regulates

Positively

Inferred To

ESRRA [nucleoplasm] (Bos taurus)

ESRRA [nucleoplasm] (Canis familiaris)

ESRRA [nucleoplasm] (Sus scrofa)

Esrra [nucleoplasm] (Mus musculus)

Esrra [nucleoplasm] (Rattus norvegicus)

knrl [nucleoplasm] (Drosophila melanogaster)

esrra [nucleoplasm] (Xenopus tropicalis)

ERR [nucleoplasm] (Drosophila melanogaster)

kni [nucleoplasm] (Drosophila melanogaster)

Homologues of ESRRA [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001269379.1, NP_004442.3, NP_001269380.1

ZINC - World Drugs

ERR1_HUMAN

Guide to Pharmacology - Targets

622

OpenTargets

ENSG00000173153

ENSEMBL

ENST00000677967, ENSP00000384851, ENSP00000503245, ENSP00000000442, ENST00000000442, ENST00000405666

ZINC - FDA approved

ERR1_HUMAN

ZINC - Substances

ERR1_HUMAN

ZINC - Biogenic

ERR1_HUMAN

ZINC target

P11474

PRO

P11474

PDB

3K6P, 7E2E, 3D24, 2PJL, 1XB7

ZINC - Investigational

ERR1_HUMAN

ZINC - Metabolites

ERR1_HUMAN

HPA

ENSG00000173153-ESRRA

Pharos - Targets

P11474

ZINC - Predictions - Purchasable

ERR1_HUMAN

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.894	20
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.576	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.573	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:P62508-3 ESRRG			0.556	3
UniProt:P48788 TNNI2	1	TNNI2 [cytosol] (R-HSA-390538)	0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
IntAct:EBI-20184588 DR0			0.544	5
IntAct:EBI-20185384 ERE			0.544	3
UniProt:P55854 SUMO3	5	UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611) SUMO3 [nucleoplasm] (R-HSA-2984269) lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm] (R-HSA-9761547) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627) SUMO3(1-103) [nucleoplasm] (R-HSA-2990830)	0.463	2

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