Reactome | CHRM4 [plasma membrane]

CHRM4 [plasma membrane]

Stable Identifier

R-HSA-390693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

M4, RecName: Full=Muscarinic acetylcholine receptor M4;
GN Name=CHRM4;
OS Homo sapiens, ACM4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        CHRM2,4 bind acetylcholine (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 binds CHRM4 antagonists (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4:CHRM4 antagonists [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08173 CHRM4

Gene Names

CHRM4

Chain

chain:1-479

Reference Genes

BioGPS Gene:1132 CHRM4

COSMIC (genes):CHRM4 CHRM4

CTD Gene:1132 CHRM4

dbSNP Gene:1132 CHRM4

ENSEMBL:ENSG00000180720 CHRM4

HGNC:1953 CHRM4

KEGG:hsa:1132 CHRM4

Monarch:1132 CHRM4

NCBI Gene:1132 CHRM4

OMIM:118495 CHRM4

UCSC:P08173 CHRM4

Reference Transcript

RefSeq:NM_000741.3 CHRM4

Other Identifiers

1132

11746745_a_at

16737715

221357_PM_at

221357_at

242203_PM_at

242203_at

3371538

3371539

3371540

3371541

3371542

3371543

3371552

61404_at

7947649

ADDON002751.hg

A_23_P104845

A_33_P3367850

GE568378

GO:0004930

GO:0004993

GO:0005886

GO:0007165

GO:0007166

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0016020

GO:0016907

GO:0023052

GO:0030425

GO:0040012

GO:0045202

GO:0045211

GO:0060089

GO:0095500

GO:0098664

HMNXSV003014354

Hs.9801.0.A1_3p_at

ILMN_1660882

M16405_at

PH_hs_0032309

TC11001719.hg

g4502820_3p_at

Participates

as a component of

CHRM4:CHRM4 antagonists [plasma membrane] (Homo sapiens)

as an input of

CHRM4 binds CHRM4 antagonists (Homo sapiens)

as a member of

CHRM2,CHRM4 [plasma membrane] (Homo sapiens)

Inferred To

Chrm4 [plasma membrane] (Mus musculus)

Chrm4 [plasma membrane] (Rattus norvegicus)

CHRM4 [plasma membrane] (Canis familiaris)

CHRM4 [plasma membrane] (Gallus gallus)

CHRM4 [plasma membrane] (Sus scrofa)

gar-3 [plasma membrane] (Caenorhabditis elegans)

chrm4 [plasma membrane] (Xenopus tropicalis)

mAChR-A [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_000732.2

ZINC - World Drugs

ACM4_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000180720

ENSEMBL

ENST00000433765, ENST00000682254, ENSP00000409378, ENSP00000507561

ZINC - FDA approved

ACM4_HUMAN

ZINC - Substances

ACM4_HUMAN

ZINC - Biogenic

ACM4_HUMAN

ZINC target

P08173

PRO

P08173

GlyGen

P08173

PDB

7TRQ, 7TRS, 6D9H, 8IYH, 7V69, 8JER, 7LD4, 8E9X, 7LD3, 8IYW, 8JHN, 7V6A, 7V68, 5DSG, 7TRK, 6KP6, 7TRP, 8FX5

ZINC - Investigational

ACM4_HUMAN

ZINC - Metabolites

ACM4_HUMAN

HPA

ENSG00000180720-CHRM4

Pharos - Targets

P08173

ZINC - Predictions - Purchasable

ACM4_HUMAN

HMDB Protein

HMDBP10811

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.527	2
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.527	2
UniProt:Q6PJG6 BRAT1			0.527	2
UniProt:P15170 GSPT1	1	GSPT1 [cytosol] (R-HSA-8865759)	0.527	2
UniProt:Q6ZMG9 CERS6	1	CERS6 [endoplasmic reticulum membrane] (R-HSA-428145)	0.527	2
UniProt:O43264 ZW10	1	ZW10 [cytosol] (R-HSA-377880)	0.527	2
UniProt:Q9UPU5 USP24	1	USP24 [nucleoplasm] (R-HSA-5697004)	0.527	2
UniProt:Q99808 SLC29A1	1	SLC29A1 [plasma membrane] (R-HSA-54335)	0.527	2
UniProt:Q13509 TUBB3	6	TUBB3 [cytosol] (R-HSA-190532) TUBB3 [axonemal microtubule] (R-HSA-5610436) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) TUBB3 unfolded [cytosol] (R-HSA-392770) TUBB3 folding intermediate [cytosol] (R-HSA-392806)	0.527	2
UniProt:Q96P70 IPO9			0.527	2
UniProt:Q86Y56 DAAF5			0.527	2
UniProt:Q5VYK3 ECM29			0.527	2
UniProt:O94768 ST17B			0.527	2
UniProt:P50748 KNTC1	1	KNTC1 [cytosol] (R-HSA-376233)	0.527	2
UniProt:Q9H3S5 PIGM	1	PIGM [endoplasmic reticulum membrane] (R-HSA-162816)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:Q7Z4Q2 HEAT3			0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	2
UniProt:Q6SZW1 SARM1			0.527	2
UniProt:Q5SWA1 PR15B			0.527	2
UniProt:Q9BSJ2 TUBGCP2	1	TUBGCP2 [cytosol] (R-HSA-379275)	0.527	2
UniProt:Q9UPN7 PPP6R1	1	PPP6R1 [cytosol] (R-HSA-5685721)	0.527	2
UniProt:Q6P1A2 LPCAT3	1	LPCAT3 [endoplasmic reticulum membrane] (R-HSA-428994)	0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	2
UniProt:Q643R3 LPCAT4	1	LPCAT4 [endoplasmic reticulum membrane] (R-HSA-1498768)	0.527	2
UniProt:P33981 TTK			0.527	2
UniProt:Q6P9B9 INTS5	1	INTS5 [nucleoplasm] (R-HSA-6807418)	0.527	2
UniProt:Q658Y4 FAM91A1	1	FAM91A1 [cytosol] (R-HSA-9714670)	0.527	2
UniProt:P62873-1 GNB1			0.488	2
UniProt:P59768 GNG2	1	GNG2 [plasma membrane] (R-HSA-164380)	0.488	2
UniProt:P04899-1 GNAI2			0.488	2
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.471	2