Reactome | CHRM4 [plasma membrane]

CHRM4 [plasma membrane]

Stable Identifier

R-HSA-390693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

M4, RecName: Full=Muscarinic acetylcholine receptor M4;
GN Name=CHRM4;
OS Homo sapiens, ACM4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        CHRM2,4 bind acetylcholine (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 binds CHRM4 antagonists (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4:CHRM4 antagonists [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08173 CHRM4

Gene Names

CHRM4

Chain

chain:1-479

Reference Genes

BioGPS Gene:1132 CHRM4

COSMIC (genes):CHRM4 CHRM4

CTD Gene:1132 CHRM4

dbSNP Gene:1132 CHRM4

ENSEMBL:ENSG00000180720.8 CHRM4

HGNC:1953 CHRM4

KEGG Gene (Homo sapiens):1132 CHRM4

Monarch:1132 CHRM4

NCBI Gene:1132 CHRM4

OMIM:118495 CHRM4

UCSC:P08173 CHRM4

Reference Transcript

RefSeq:NM_000741.3 CHRM4

Other Identifiers

0005220541

1132

11746745_a_at

16737715

221357_PM_at

221357_at

242203_PM_at

242203_at

3371538

3371539

3371540

3371541

3371542

3371543

3371552

61404_at

7947649

ADDON002751.hg

A_23_P104845

A_33_P3367850

GE568378

GO:0004930

GO:0004993

GO:0005886

GO:0005887

GO:0007165

GO:0007166

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0016020

GO:0016021

GO:0016907

GO:0023052

GO:0030425

GO:0030594

GO:0040012

GO:0045202

GO:0045211

GO:0060089

GO:0095500

GO:0098664

HMNXSV003014354

Hs.9801.0.A1_3p_at

ILMN_1660882

M16405_at

PH_hs_0032309

TC11001719.hg

g4502820_3p_at

Participates

as a component of

CHRM4:CHRM4 antagonists [plasma membrane] (Homo sapiens)

as an input of

CHRM4 binds CHRM4 antagonists (Homo sapiens)

as a member of

CHRM2,CHRM4 [plasma membrane] (Homo sapiens)

Inferred To

gar-2 [plasma membrane] (Caenorhabditis elegans)

Chrm4 [plasma membrane] (Mus musculus)

Chrm4 [plasma membrane] (Rattus norvegicus)

CHRM4 [plasma membrane] (Canis familiaris)

CHRM4 [plasma membrane] (Danio rerio)

CHRM4 [plasma membrane] (Gallus gallus)

CHRM4 [plasma membrane] (Sus scrofa)

gar-3 [plasma membrane] (Caenorhabditis elegans)

mAChR-B [plasma membrane] (Drosophila melanogaster)

chrm4 [plasma membrane] (Xenopus tropicalis)

Homologues of CHRM4 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRM4 [plasma membrane] (Drosophila melanogaster)

mAChR-A [plasma membrane] (Drosophila melanogaster)

gar-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000732.2

ZINC - World Drugs

ACM4_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000180720

ZINC - FDA approved

ACM4_HUMAN

ZINC - Substances

ACM4_HUMAN

ZINC target

P08173

ZINC - Biogenic

ACM4_HUMAN

PRO

P08173

PDB

6D9H, 5DSG, 6KP6, 7LD4, 7LD3

ZINC - Investigational

ACM4_HUMAN

ZINC - Metabolites

ACM4_HUMAN

HPA

ENSG00000180720-CHRM4

GeneCards

P08173

Ensembl

ENST00000433765, ENST00000682254, ENSP00000507561, ENSP00000409378, ENSG00000180720

Pharos - Targets

P08173

ZINC - Predictions - Purchasable

ACM4_HUMAN

HMDB Protein

HMDBP10811

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62873-1 GNB1			0.488	2
UniProt:P59768 GNG2	1	GNG2 [plasma membrane] (R-HSA-164380)	0.488	2
UniProt:P04899-1 GNAI2			0.488	2
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.471	2