Reactome | CHRM4 [plasma membrane]

CHRM4 [plasma membrane]

Stable Identifier

R-HSA-390693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

M4, RecName: Full=Muscarinic acetylcholine receptor M4;
GN Name=CHRM4;
OS Homo sapiens, ACM4_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        GPCRs that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        M2 and M4 receptors bind acetylcholine (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM2,CHRM4 [plasma membrane] (Homo sapiens)
        
        CHRM4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08173 CHRM4

Gene Names

CHRM4

Chain

chain:1-479

Reference Genes

BioGPS Gene:1132 CHRM4

COSMIC (genes):CHRM4 CHRM4

CTD Gene:1132 CHRM4

dbSNP Gene:1132 CHRM4

ENSEMBL:ENSG00000180720 CHRM4

HGNC:1953 CHRM4

KEGG Gene (Homo sapiens):1132 CHRM4

Monarch:1132 CHRM4

NCBI Gene:1132 CHRM4

OMIM:118495 CHRM4

UCSC:P08173 CHRM4

Reference Transcript

RefSeq:NM_000741.3 CHRM4

Other Identifiers

0005220541

1132

11746745_a_at

16737715

221357_at

22444

3371543

5DSG

6D9H

72083

7947649

A_23_P104845

A_33_P3367850

AAA51571

AAH95546

AAI19776

AAI19818

AAI37536

AAM18941

ADDON002751.hg

AF498918

BC095546

BC119775

BC119817

BC137535

CAA33336

CAB022444

CCDS44581

CH471064

CHRM4

CHRM4-201

EAW68004

ENSG00000180720

ENSP00000409378

ENST00000433765

ENST00000433765.3

EntrezGene:1132

EntrezGene:CHRM4

g4502820_3p_at

GE568378

GO:0003674

GO:0004930

GO:0004993

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0007165

GO:0007166

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007267

GO:0007268

GO:0008150

GO:0016020

GO:0016021

GO:0016907

GO:0030054

GO:0030425

GO:0030594

GO:0040011

GO:0040012

GO:0045202

GO:0045211

GO:0098664

HGNC:1953

HPA072083

ILMN_1660882

IPR000276

IPR000995

IPR001432

IPR017452

M16405

MIM:118495

NM_000741

NM_001366692

NP_000732

NP_001353621

PF00001

PH_hs_0032309

PR00237

PR00243

PR00541

SM01381

TC11001719.hg

UPI00001252BB

X15265

Participant Of

hasMember

CHRM2,CHRM4 [plasma membrane]

Inferred To

CHRM4 [plasma membrane] (Caenorhabditis elegans)

CHRM4 [plasma membrane] (Canis familiaris)

CHRM4 [plasma membrane] (Danio rerio)

CHRM4 [plasma membrane] (Drosophila melanogaster)

CHRM4 [plasma membrane] (Mus musculus)

CHRM4 [plasma membrane] (Rattus norvegicus)

CHRM4 [plasma membrane] (Sus scrofa)

CHRM4 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000732.2

ZINC - World Drugs

ACM4_HUMAN

OpenTargets

ENSG00000180720

ZINC - FDA approved

ACM4_HUMAN

ZINC - Substances

ACM4_HUMAN

ZINC - Biogenic

ACM4_HUMAN

ZINC target

P08173

PRO

P08173

PDB

6D9H, 5DSG

ZINC - Investigational

ACM4_HUMAN

ZINC - Metabolites

ACM4_HUMAN

GeneCards

P08173

ZINC - Predictions - Purchasable

ACM4_HUMAN

HMDB Protein

HMDBP10811