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COG2 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6813863
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Conserved oligomeric Golgi complex subunit 2, COG2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG2 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG2 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG2 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
COG complex [trans-Golgi network membrane] (Homo sapiens)
COG2 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14746 COG2
Gene Names
COG2, LDLC
Chain
chain:1-738
Reference Genes
BioGPS Gene:22796 COG2
COSMIC (genes):COG2 COG2
CTD Gene:22796 COG2
dbSNP Gene:22796 COG2
ENSEMBL:ENSG00000135775 COG2
ENSEMBL_homo_sapiens_GENE:ENSG00000135775.14 COG2
HGNC:6546 COG2
KEGG Gene (Homo sapiens):22796 COG2
Monarch:22796 COG2
NCBI Gene:22796 COG2
OMIM:606974 COG2
UCSC:Q14746 COG2
Reference Transcript
RefSeq:NM_007357.2 COG2
RefSeq:NM_001145036.1 COG2
Other Identifiers
11743607_a_at
11747061_a_at
16678611
203073_PM_at
203073_at
22796
2384957
2384958
2384961
2384962
2384965
2384966
2384967
2384969
2384970
2384972
2384973
2384974
2384976
2384979
2384980
2384982
2384984
2384985
2384986
2384988
2384989
2384993
2384994
2384995
2384996
2384997
38390_at
7910446
A_14_P134639
A_23_P160809
A_24_P310946
GE60396
GO:0000139
GO:0000301
GO:0005515
GO:0005794
GO:0005795
GO:0006891
GO:0007030
GO:0015031
GO:0016020
GO:0016192
GO:0017119
GO:0032588
GO:0043226
GO:0044877
GO:0070085
HMNXSV003047866
ILMN_1776993
PH_hs_0004719
TC01001909.hg
Z34975_at
g6678675_3p_at
Participates
as a component of
COG complex [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
COG2 [Golgi membrane]
Inferred To
cog2 [trans-Golgi network membrane]
(Dictyostelium discoideum)
Ghost homologue of COG2 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
COG2 [trans-Golgi network membrane]
(Bos taurus)
COG2 [trans-Golgi network membrane]
(Canis familiaris)
COG2 [trans-Golgi network membrane]
(Gallus gallus)
COG2 [trans-Golgi network membrane]
(Sus scrofa)
Cog2 [trans-Golgi network membrane]
(Drosophila melanogaster)
Cog2 [trans-Golgi network membrane]
(Mus musculus)
Cog2 [trans-Golgi network membrane]
(Rattus norvegicus)
cogc-2 [trans-Golgi network membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_031383.1
,
NP_001138508.1
OpenTargets
ENSG00000135775
GeneCards
Q14746
HPA
ENSG00000135775-COG2
Ensembl
ENST00000366669
,
ENST00000366668
,
ENSP00000355628
,
ENSP00000355629
,
ENSG00000135775
PRO
Q14746
Pharos - Targets
Q14746
Orphanet
23509
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
ALOX5 [cytosol]
(R-HSA-429010)
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
0.527
2
UniProt:Q9NZQ7 CD274
1
CD274 [plasma membrane]
(R-HSA-3211776)
0.527
2
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.527
2
UniProt:P08173 CHRM4
1
CHRM4 [plasma membrane]
(R-HSA-390693)
0.527
2
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