Reactome | COG2 [Golgi membrane]

COG2 [Golgi membrane]

Stable Identifier

R-HSA-5216080

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Conserved oligomeric Golgi complex subunit 2, COG2_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14746 COG2

Gene Names

COG2, LDLC

Chain

chain:1-738

Reference Genes

BioGPS Gene:22796 COG2

COSMIC (genes):COG2 COG2

CTD Gene:22796 COG2

dbSNP Gene:22796 COG2

ENSEMBL:ENSG00000135775.14 COG2

HGNC:6546 COG2

KEGG Gene (Homo sapiens):22796 COG2

Monarch:22796 COG2

NCBI Gene:22796 COG2

OMIM:606974 COG2

UCSC:Q14746 COG2

Reference Transcript

Other Identifiers

0000540538

11743607_a_at

11747061_a_at

16678611

203073_PM_at

203073_at

22796

2384957

2384958

2384961

2384962

2384965

2384966

2384967

2384969

2384970

2384972

2384973

2384974

2384976

2384979

2384980

2384982

2384984

2384985

2384986

2384988

2384989

2384993

2384994

2384995

2384996

2384997

38390_at

7910446

A_14_P134639

A_23_P160809

A_24_P310946

GE60396

GO:0000139

GO:0000301

GO:0005515

GO:0005622

GO:0005737

GO:0005794

GO:0005795

GO:0005829

GO:0006891

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0032991

GO:0043226

GO:0044877

GO:0070085

HMNXSV003047866

ILMN_1776993

PH_hs_0004719

TC01001909.hg

Z34975_at

g6678675_3p_at

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG2 [trans-Golgi network membrane]

Inferred To

COG2 [Golgi membrane] (Bos taurus)

COG2 [Golgi membrane] (Canis familiaris)

COG2 [Golgi membrane] (Danio rerio)

COG2 [Golgi membrane] (Gallus gallus)

COG2 [Golgi membrane] (Sus scrofa)

Cog2 [Golgi membrane] (Drosophila melanogaster)

Cog2 [Golgi membrane] (Mus musculus)

Cog2 [Golgi membrane] (Rattus norvegicus)

Ghost homologue of COG2 [Golgi membrane] (Schizosaccharomyces pombe)

cog2 [Golgi membrane] (Dictyostelium discoideum)

cog2 [Golgi membrane] (Xenopus tropicalis)

cogc-2 [Golgi membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_031383.1, NP_001138508.1

OpenTargets

ENSG00000135775

GeneCards

Q14746

HPA

ENSG00000135775-COG2

Ensembl

ENSP00000355628, ENSP00000355629, ENSG00000135775, ENST00000366668, ENST00000366669

PRO

Q14746

Pharos - Targets

Q14746

Orphanet

23509

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