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COG2 [Golgi membrane]
Stable Identifier
R-HSA-5216080
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Conserved oligomeric Golgi complex subunit 2, COG2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
The COG complex binds RABs at the Golgi membrane (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
COG complex:RABs [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
COG complex:Golgi snares [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG2 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14746 COG2
Gene Names
COG2, LDLC
Chain
chain:1-738
Reference Genes
BioGPS Gene:22796 COG2
COSMIC (genes):COG2 COG2
CTD Gene:22796 COG2
dbSNP Gene:22796 COG2
ENSEMBL:ENSG00000135775.14 COG2
HGNC:6546 COG2
KEGG Gene (Homo sapiens):22796 COG2
Monarch:22796 COG2
NCBI Gene:22796 COG2
OMIM:606974 COG2
UCSC:Q14746 COG2
Reference Transcript
RefSeq:NM_007357.2 COG2
RefSeq:NM_001145036.1 COG2
Other Identifiers
0000540538
11743607_a_at
11747061_a_at
16678611
203073_PM_at
203073_at
22796
2384957
2384958
2384961
2384962
2384965
2384966
2384967
2384969
2384970
2384972
2384973
2384974
2384976
2384979
2384980
2384982
2384984
2384985
2384986
2384988
2384989
2384993
2384994
2384995
2384996
2384997
38390_at
7910446
A_14_P134639
A_23_P160809
A_24_P310946
GE60396
GO:0000139
GO:0000301
GO:0005515
GO:0005622
GO:0005737
GO:0005794
GO:0005795
GO:0005829
GO:0006891
GO:0007030
GO:0015031
GO:0016020
GO:0016192
GO:0017119
GO:0032588
GO:0032991
GO:0043226
GO:0044877
GO:0070085
HMNXSV003047866
ILMN_1776993
PH_hs_0004719
TC01001909.hg
Z34975_at
g6678675_3p_at
Participates
as a component of
COG complex [Golgi membrane] (Homo sapiens)
Other forms of this molecule
COG2 [trans-Golgi network membrane]
Inferred To
COG2 [Golgi membrane]
(Bos taurus)
COG2 [Golgi membrane]
(Canis familiaris)
COG2 [Golgi membrane]
(Danio rerio)
COG2 [Golgi membrane]
(Gallus gallus)
COG2 [Golgi membrane]
(Sus scrofa)
Cog2 [Golgi membrane]
(Drosophila melanogaster)
Cog2 [Golgi membrane]
(Mus musculus)
Cog2 [Golgi membrane]
(Rattus norvegicus)
Ghost homologue of COG2 [Golgi membrane]
(Schizosaccharomyces pombe)
cog2 [Golgi membrane]
(Dictyostelium discoideum)
cog2 [Golgi membrane]
(Xenopus tropicalis)
cogc-2 [Golgi membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_031383.1
,
NP_001138508.1
OpenTargets
ENSG00000135775
GeneCards
Q14746
HPA
ENSG00000135775-COG2
Ensembl
ENSP00000355628
,
ENSP00000355629
,
ENSG00000135775
,
ENST00000366668
,
ENST00000366669
PRO
Q14746
Pharos - Targets
Q14746
Orphanet
23509
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