Reactome | TUBGCP2 [cytosol]

TUBGCP2 [cytosol]

Stable Identifier

R-HSA-379275

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GCP-2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBGCP2 [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBGCP2 [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBGCP2 [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBGCP2 [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBGCP2 [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBGCP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BSJ2 TUBGCP2

Gene Names

TUBGCP2, GCP2

Chain

chain:1-902

Reference Genes

BioGPS Gene:10844 TUBGCP2

COSMIC (genes):TUBGCP2 TUBGCP2

CTD Gene:10844 TUBGCP2

dbSNP Gene:10844 TUBGCP2

ENSEMBL:ENSG00000130640 TUBGCP2

HGNC:18599 TUBGCP2

KEGG:hsa:10844 TUBGCP2

Monarch:10844 TUBGCP2

NCBI Gene:10844 TUBGCP2

OMIM:617817 TUBGCP2

UCSC:Q9BSJ2 TUBGCP2

Reference Transcript

Other Identifiers

10844

11718342_a_at

11718343_a_at

11745125_a_at

11761281_at

11761282_x_at

16719838

16719866

202476_PM_s_at

202476_s_at

202477_PM_s_at

202477_s_at

244842_PM_x_at

244842_x_at

3315093

3315094

3315095

3315096

3315097

3315102

3315103

3315105

3315106

3315108

3315110

3315111

3315113

3315115

3315116

3315117

3315120

3315121

3315122

3315123

3315124

3315125

3315126

3315127

3315128

3315129

3315130

3315131

3315132

3315133

3315135

3315136

3315137

3315138

3315139

3315140

3315141

3315142

3315143

3315144

3315145

3315148

3315149

3315150

3315151

3315152

3315153

3315154

3315155

3315156

3315157

3315158

3315159

3315160

3315164

3315165

3315166

3315167

3315168

3315169

3315170

3315171

3315172

3315174

3315175

39918_at

66676_at

79362_at

7937175

80214_r_at

GE54370

GE63353

GE792129

GO:0000226

GO:0000278

GO:0000922

GO:0000923

GO:0000930

GO:0001764

GO:0005515

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005881

GO:0007010

GO:0007020

GO:0007420

GO:0008092

GO:0016020

GO:0022414

GO:0031122

GO:0043015

GO:0043226

GO:0048856

GO:0048870

GO:0051011

GO:0051225

GO:0051321

GO:0065003

HMNXSV003004578

HMNXSV003022266

Hs.13386.0.A1_3p_a_at

Hs.271487.0.A1_3p_at

ILMN_1775074

ILMN_1856818

PH_hs_0008756

PH_hs_0028259

TC10001784.hg

TC10001785.hg

g5729839_3p_a_at

p1805

p33655

Participates

as a component of

gamma-TuSC [cytosol] (Homo sapiens)

Inferred To

tubgcp2 [cytosol] (Xenopus tropicalis)

Tubgcp2 [cytosol] (Mus musculus)

TUBGCP2 [cytosol] (Bos taurus)

TUBGCP2 [cytosol] (Canis familiaris)

TUBGCP2 [cytosol] (Gallus gallus)

TUBGCP2 [cytosol] (Rattus norvegicus)

TUBGCP2 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000130640

ENSEMBL

ENSP00000252936, ENST00000543663, ENST00000252936, ENSP00000506731, ENSG00000130640, ENSP00000507610, ENSP00000507482, ENST00000417178, ENSP00000446093, ENST00000682123, ENST00000683612, ENST00000682515, ENSP00000395666

HPA

ENSG00000130640-TUBGCP2

GeneCards

TUBGCP2

PRO

Q9BSJ2

Pharos - Targets

Q9BSJ2

GlyGen

Q9BSJ2

PDB

7AS4, 7QJ9, 8RX1, 7QJB, 7QJ4, 7QJ8, 7QJ6, 7QJ3, 7QJ7, 6X0V, 7QJ5, 7QJ2, 7QJ0, 8Q62, 6V6S, 7QJD, 6V6B, 7QJ1, 8VRJ, 7QJA, 7QJC, 8VRK, 8VRD

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2