Reactome | CERS6 [endoplasmic reticulum membrane]

CERS6 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428145

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LASS6, LAG1 homolog, ceramide synthase 6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q6ZMG9 CERS6

Gene Names

CERS6, LASS6

Chain

chain:1-384

Reference Genes

BioGPS Gene:253782 Q6ZMG92

COSMIC (genes):CERS6 CERS6

CTD Gene:253782 Q6ZMG92

dbSNP Gene:253782 Q6ZMG92

ENSEMBL:ENSG00000172292 CERS6

HGNC:23826 Q6ZMG92

KEGG:hsa:253782 Q6ZMG92

Monarch:253782 Q6ZMG92

NCBI Gene:253782 Q6ZMG92

OMIM:615336 Q6ZMG92

UCSC:Q6ZMG9 Q6ZMG92

Reference Transcript

Participates

as a member of

Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

CERS6 [endoplasmic reticulum membrane] (Bos taurus)

CERS6 [endoplasmic reticulum membrane] (Canis familiaris)

CERS6 [endoplasmic reticulum membrane] (Gallus gallus)

CERS6 [endoplasmic reticulum membrane] (Plasmodium falciparum)

CERS6 [endoplasmic reticulum membrane] (Sus scrofa)

crsA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

LAG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

schlank [endoplasmic reticulum membrane] (Drosophila melanogaster)

cers6 [endoplasmic reticulum membrane] (Xenopus tropicalis)

hyl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

LAC1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

lag1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cers6 [endoplasmic reticulum membrane] (Mus musculus)

Cers6 [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of CERS6 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cross References

Guide to Pharmacology - Targets

2479

ENSEMBL

ENSP00000306579, ENSG00000172292, ENST00000392687, ENST00000305747, ENSP00000376453

OpenTargets

ENSG00000172292

GeneCards

CERS6

HPA

ENSG00000172292-CERS6

PRO

Q6ZMG9

Pharos - Targets

Q6ZMG9

GlyGen

Q6ZMG9

HMDB Protein

HMDBP11633

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41146 OPRL1	1	OPRL1 [plasma membrane] (R-HSA-374731)	0.632	3
UniProt:P25090 FPR2	4	FPR2 [plasma membrane] (R-HSA-416408) FPR2 [tertiary granule membrane] (R-HSA-6803296) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335)	0.527	3
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [specific granule membrane] (R-HSA-6799516) C3AR1 [azurophil granule membrane] (R-HSA-6799517)	0.527	2
UniProt:P30556 AGTR1	2	AGTR1 [plasma membrane] (R-HSA-374247) AGTR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869071)	0.508	2

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