Reactome | Chrm4 [plasma membrane]

Chrm4 [plasma membrane]

Stable Identifier

R-MMU-390693

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

CHRM4, P32211

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Muscarinic acetylcholine receptors (Mus musculus)
        
        CHRM2,4 bind acetylcholine (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Mus musculus)
        
        CHRM2,CHRM4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
        
        CHRM4 binds CHRM4 antagonists (Mus musculus)
        
        CHRM4:CHRM4 antagonists [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)
        
        Chrm4 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P32211

Gene Names

Chrm4

Reference Genes

BioGPS Gene:12672 Chrm4

ENSEMBL:ENSMUSG00000040495

KEGG:mmu:12672 Chrm4

Monarch:12672 Chrm4

NCBI Gene:12672 Chrm4

UCSC:P32211 Chrm4

Reference Transcript

Other Identifiers

101821_at

10474002

12672

1450575_at

17373443

4639150

4797426

5316001

A_52_P88054

GE34854

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0016020

GO:0016907

GO:0030054

GO:0030425

GO:0040012

GO:0045202

GO:0045211

ILMN_2748556

Msa.2429.0_at

mMC018600

Participates

as an input of

CHRM4 binds CHRM4 antagonists (Mus musculus)

as a component of

CHRM4:CHRM4 antagonists [plasma membrane] (Mus musculus)

as a member of

CHRM2,CHRM4 [plasma membrane] (Mus musculus)

Inferred From

CHRM4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_031725.1, NP_001403867.1

ENSEMBL

ENSMUSG00000040495, ENSMUST00000045537, ENSMUSP00000040808

ZINC - Substances

ACM4_MOUSE

ZINC target

P32211

PRO

P32211

GlyGen

P32211

MGI

88399

ZINC - Predictions - Purchasable

ACM4_MOUSE