Reactome | HTR2C [plasma membrane]

HTR2C [plasma membrane]

Stable Identifier

R-HSA-390965

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-HT2C receptor, RecName: Full=5-hydroxytryptamine receptor 2C; Short=5-HTR2C; Short=5-HT-2C; Short=5-HT2C; AltName: Full=5HT-1C; AltName: Full=Serotonin receptor 2C;
GN Name=HTR2C; Synonyms=HTR1C;
OS Homo sapiens, 5HT2C_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        HTR2A-C:5HT [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        HTR2A-C:5HT [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        HTR2A-C:5HT [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        HTR2A-C:5HT [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        HTR2A-C:5HT [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        5-HT2 receptor can bind serotonin (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)
        
        HTR2A-C:5HT [plasma membrane] (Homo sapiens)
        
        HTR2A-C [plasma membrane] (Homo sapiens)
        
        HTR2C [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28335 HTR2C

Gene Names

HTR2C, HTR1C

Chain

signal peptide:1-32, chain:33-458

Reference Genes

BioGPS Gene:3358 HTR2C

COSMIC (genes):HTR2C HTR2C

CTD Gene:3358 HTR2C

dbSNP Gene:3358 HTR2C

ENSEMBL:ENSG00000147246 HTR2C

HGNC:5295 HTR2C

KEGG:hsa:3358 HTR2C

Monarch:3358 HTR2C

NCBI Gene:3358 HTR2C

OMIM:312861 HTR2C

UCSC:P28335 HTR2C

Reference Transcript

Other Identifiers

11748506_a_at

11749126_a_at

11755418_a_at

17106314

207307_PM_at

207307_at

211479_PM_s_at

211479_s_at

33550_at

33551_s_at

3358

3987877

3987878

3987879

3987883

3987892

3987893

3987894

3987895

3987896

3987900

3987901

3987903

3987904

8169447

A_14_P104999

A_14_P115707

A_14_P136820

A_23_P433586

A_33_P3319176

GE80222

GO:0001587

GO:0001662

GO:0004930

GO:0004993

GO:0005515

GO:0005886

GO:0006874

GO:0007186

GO:0007187

GO:0007200

GO:0007208

GO:0007210

GO:0007268

GO:0007626

GO:0007631

GO:0010513

GO:0016020

GO:0019934

GO:0023052

GO:0030425

GO:0030594

GO:0031644

GO:0032098

GO:0042802

GO:0043397

GO:0045202

GO:0045600

GO:0050850

GO:0051209

GO:0051378

GO:0055085

GO:0060089

GO:0070374

GO:0071886

GO:0098664

GO:0098666

GO:0099589

HMNXSV003001408

HMNXSV003057629

HMNXSV003058412

ILMN_1660097

ILMN_1801357

M81778_s_at

PH_hs_0003283

TC0X000555.hg

U49516_at

X80763_s_at

g338027_3p_a_at

g4504540_3p_at

Participates

as a member of

HTR2A-C [plasma membrane] (Homo sapiens)

Inferred To

htr2cl1 [plasma membrane] (Danio rerio)

5-HT2B [plasma membrane] (Drosophila melanogaster)

htr2c [plasma membrane] (Xenopus tropicalis)

HTR2C [plasma membrane] (Canis familiaris)

HTR2C [plasma membrane] (Gallus gallus)

HTR2C [plasma membrane] (Mus musculus)

HTR2C [plasma membrane] (Rattus norvegicus)

HTR2C [plasma membrane] (Sus scrofa)

dop-6 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001243689.1, NP_000859.1, NP_001243690.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000147246

ENSEMBL

ENSP00000276198, ENSG00000147246, ENST00000371951, ENST00000371950, ENSP00000361018, ENSP00000361019, ENST00000276198

ZINC - FDA approved

5HT2C_HUMAN

ZINC - Substances

5HT2C_HUMAN

ZINC - Biogenic

5HT2C_HUMAN

ZINC target

P28335

PRO

P28335

GlyGen

P28335

PDB

8DPF, 8DPG, 6BQH, 6BQG, 8DPH, 8ZMF, 8DPI

ZINC - Investigational

5HT2C_HUMAN

ZINC - Metabolites

5HT2C_HUMAN

HPA

ENSG00000147246-HTR2C

GeneCards

HTR2C

Pharos - Targets

P28335

ZINC - Predictions - Purchasable

5HT2C_HUMAN

HMDB Protein

HMDBP02700

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95406 CNIH1	3	CNIH1 [endoplasmic reticulum membrane] (R-HSA-5689439) CNIH1 [ER to Golgi transport vesicle membrane] (R-HSA-5689776) CNIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689778)	0.556	3
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	2
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.527	2
UniProt:P17931 LGALS3	3	LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307)	0.527	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.471	2