Reactome | CHRM4 [plasma membrane]

CHRM4 [plasma membrane]

Stable Identifier

R-CFA-390693

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CHRM4, A0A8I3Q4F7

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Amine ligand-binding receptors (Canis familiaris)
        
        Muscarinic acetylcholine receptors (Canis familiaris)
        
        CHRM2,4 bind acetylcholine (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4 binds CHRM4 antagonists (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM4:CHRM4 antagonists [plasma membrane] (Canis familiaris)
        
        CHRM4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q4F7

Gene Names

CHRM4

Reference Genes

ENSEMBL:ENSCAFG00845028143.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028143.1 CHRM4

Other Identifiers

611314

CfaAffx.14514.1.S1_at

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0007197

GO:0016020

GO:0016907

GO:0023052

GO:0030054

GO:0040012

GO:0045202

GO:0045211

GO:0060089

GO:0097060

Participates

as an input of

CHRM4 binds CHRM4 antagonists (Canis familiaris)

as a component of

CHRM4:CHRM4 antagonists [plasma membrane] (Canis familiaris)

as a member of

CHRM2,CHRM4 [plasma membrane] (Canis familiaris)

Inferred From

CHRM4 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000180720

Ensembl

ENSCAFT00845049659, ENSCAFG00845028143, ENSCAFP00845038951