Reactome | CTCF [nucleoplasm]

CTCF [nucleoplasm]

Stable Identifier

R-HSA-3782562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional repressor CTCF, CTCF_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P62888 RPL30

Expand all

External Reference Information

External Reference

UniProt:P49711 CTCF

Gene Names

CTCF

Chain

chain:1-727

Reference Genes

BioGPS Gene:10664 CTCF

COSMIC - genes:CTCF CTCF

CTD Gene:10664 CTCF

dbSNP Gene:10664 CTCF

ENSEMBL:ENSG00000102974 CTCF

HGNC:13723 CTCF

KEGG:hsa:10664 CTCF

Monarch:10664 CTCF

NCBI Gene:10664 CTCF

OMIM:604167 CTCF

UCSC:P49711 CTCF

Reference Transcript

Other Identifiers

10664

11755514_s_at

16820193

202521_PM_at

202521_at

35319_at

3532394

3665604

3665607

3665608

3665612

3665613

3665614

3665615

3665616

3665617

3665618

3665619

3665620

3665621

3665622

3665623

3665624

3665625

3665630

3665631

3665633

3665634

3665635

7996593

A_14_P103409

A_14_P116120

A_14_P117085

A_24_P347704

A_24_P356254

A_32_P149043

GE59031

GO:0000122

GO:0000775

GO:0000793

GO:0000976

GO:0000978

GO:0000987

GO:0001221

GO:0001227

GO:0001673

GO:0001701

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006325

GO:0006346

GO:0006355

GO:0006357

GO:0007005

GO:0007059

GO:0007507

GO:0008270

GO:0008285

GO:0010467

GO:0010557

GO:0010628

GO:0010629

GO:0030154

GO:0034502

GO:0040029

GO:0043035

GO:0043565

GO:0044027

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048856

GO:0055007

GO:0055013

GO:0070602

GO:0071459

GO:0071514

GO:0140587

GO:0140588

GO:1990837

HMNXSV003025160

ILMN_1786015

PH_hs_0024876

TC16000542.hg

U25435_at

g5729789_3p_at

Participates

as a component of

as an input of

CHD8 and CHD7 bind CTCF (Homo sapiens)

Inferred To

Dmel\CG12769 [nucleoplasm] (Drosophila melanogaster)

ztf-16 [nucleoplasm] (Caenorhabditis elegans)

Ctcf [nucleoplasm] (Rattus norvegicus)

CTCF [nucleoplasm] (Canis familiaris)

CTCF [nucleoplasm] (Danio rerio)

CTCF [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001425897.1, NP_006556.1, NP_001177951.1

OpenTargets

ENSG00000102974

ENSEMBL

ENSP00000493495, ENST00000642819, ENSP00000494538, ENST00000646076, ENSG00000102974, ENSP00000494408, ENSP00000384707, ENSP00000495348, ENSP00000264010, ENST00000401394, ENST00000644753, ENST00000645699, ENST00000264010

GeneCards

CTCF

HPA

ENSG00000102974-CTCF

PRO

P49711

Pharos - Targets

P49711

GlyGen

P49711

Orphanet

CTCF

PDB

5T00, 1X6H, 5KKQ, 2CT1, 5UND, 7W1M, 8SSR, 5K5L, 8SSQ, 5YEH, 5YEG, 8SSS, 5YEL, 8SSU, 5K5I, 5T0U, 5K5J, 6QNX, 5YEF, 8SST, 5K5H

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62899 RPL31	1	RPL31 [cytosol] (R-HSA-72454)	0.738	4
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.725	4
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.643	3
UniProt:Q15397 PUM3			0.643	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.643	3
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.643	4
UniProt:P18621 RPL17	1	RPL17 [cytosol] (R-HSA-72418)	0.643	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.615	5
UniProt:Q00341 HDLBP	2	HDLBP [plasma membrane] (R-HSA-8858026) HDLBP [endoplasmic reticulum membrane] (R-HSA-9948214)	0.581	4
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:O95789-4 ZMYM6			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q5VZL5 ZMYM4			0.556	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:Q9UL40 ZN346			0.527	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	2
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.527	3
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.527	2
UniProt:P08865 RPSA	3	RPSA [cytosol] (R-HSA-72389) RPSA [plasma membrane] (R-HSA-9922472) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:O15479 MAGB2			0.527	2
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:Q5SVZ6 ZMYM1			0.527	2
UniProt:P42766 RPL35	1	RPL35 [cytosol] (R-HSA-72460)	0.527	2
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	3
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.527	2
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.527	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	2
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	2
UniProt:P82930 MRPS34	1	MRPS34 [mitochondrial inner membrane] (R-HSA-5368186)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	2
UniProt:P16104 H2AX	8	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) acK H2AFX [nucleoplasm] (R-HSA-9943854)	0.527	3
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.527	2
UniProt:Q9BYG3 MK67I			0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557) ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	2
UniProt:Q9UGL1 KDM5B	1	KDM5B [nucleoplasm] (R-HSA-3215031)	0.524	8
IntAct:EBI-2694074 MDM2			0.499	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.463	3

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