Reactome | HIST1H1A [nucleoplasm]

HIST1H1A [nucleoplasm]

Stable Identifier

R-HSA-211245

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

histone H1.1

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
        
        SAHF formation (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1A [nucleoplasm] (Homo sapiens)
        
        Histone H1 bound chromatin DNA [nucleoplasm] (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02539 H1-1

Gene Names

H1-1, H1F1, HIST1H1A

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:3024 H1-1

COSMIC (genes):HIST1H1A H1-1

CTD Gene:3024 H1-1

dbSNP Gene:3024 H1-1

ENSEMBL:ENSG00000124610 HIST1H1A

HGNC:4715 H1-1

KEGG:hsa:3024 H1-1

Monarch:3024 H1-1

NCBI Gene:3024 H1-1

OMIM:142709 H1-1

UCSC:Q02539 H1-1

Reference Transcript

RefSeq:NM_005325.3 H1-1

Other Identifiers

11734465_at

17016356

208484_PM_at

208484_at

2946195

2946196

2946197

2946198

2946199

3024

33067_at

8124380

A_23_P70448

GE903742

GO:0000785

GO:0000786

GO:0000791

GO:0003677

GO:0003690

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0007283

GO:0008201

GO:0009986

GO:0022414

GO:0030261

GO:0030527

GO:0031490

GO:0031492

GO:0031982

GO:0043226

GO:0045910

GO:0048260

GO:0065003

HMNXSV003047157

ILMN_1692831

PH_hs_0009050

TC06001340.hg

g4885372_3p_at

Participates

as a candidate of

Histone H1 [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of HIST1H1A [nucleoplasm] (Danio rerio)

HHO1 [nucleoplasm] (Saccharomyces cerevisiae)

H1-1 [nucleoplasm] (Mus musculus)

H1-1 [nucleoplasm] (Rattus norvegicus)

H1 [nucleoplasm] (Dictyostelium discoideum)

HIST1H1A [nucleoplasm] (Danio rerio)

si:dkey-261m9.14 [nucleoplasm] (Danio rerio)

histh1l1 [nucleoplasm] (Danio rerio)

Cross References

ENSEMBL

ENSG00000124610, ENST00000244573, ENSP00000244573

OpenTargets

ENSG00000124610

GeneCards

H1-1

HPA

ENSG00000124610-H1-1

PRO

Q02539

Pharos - Targets

Q02539

GlyGen

Q02539

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	2
UniProt:O95453 PARN	1	PARN [cytosol] (R-HSA-430009)	0.527	2
UniProt:P46782 RPS5	2	RPS5 [cytosol] (R-HSA-72379) RPS5 [nucleoplasm] (R-HSA-6791188)	0.527	4
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.527	3
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.527	3
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:O15520 FGF10	1	FGF10 [extracellular region] (R-HSA-189869)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:Q8IXZ2 ZC3H3	1	ZC3H3 [nucleoplasm] (R-HSA-9933572)	0.527	2
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.527	3