Reactome | CHD8 and CHD7 bind CTCF

CHD8 and CHD7 bind CTCF

Stable Identifier

R-HSA-9944419

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

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CHD8 and CHD7 bind to the CCCTC-binding factor CTCF through the CHD BRK domains (Allen et al, 2007; Ishihara et al, 2006). The BRK domains of subfamily III CHD members are only present in metazoa and may contribute to aspects of regulation that are not conserved in lower eukaryotes (reviewed in Marfella and Imbalzano, 2007). CTCF binds to many locations in the genome and has roles in transcriptional regulation, insulator function and genomic imprinting (Recillas-Targa et al, 2006; reviewed in Dehingia et al, 2022; Rowley and Corces, 2018; Monteagudo-Sanchez et al, 2024).

Literature References

PubMed ID	Title	Journal	Year
16989720	Epigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis Recillas-Targa, F, De La Rosa-Velázquez, IA, Soto-Reyes, E, Benítez-Bribiesca, L	J Cell Mol Med	2006
17603073	Solution structure of the BRK domains from CHD7 Allen, MD, Religa, TL, Freund, SM, Bycroft, M	J Mol Biol	2007
35993175	CTCF shapes chromatin structure and gene expression in health and disease Dehingia, B, Milewska, M, Janowski, M, Pękowska, A	EMBO Rep	2022
30367165	Organizational principles of 3D genome architecture Rowley, MJ, Corces, VG	Nat Rev Genet	2018
17350655	The Chd family of chromatin remodelers Marfella, CG, Imbalzano, AN	Mutat. Res.	2007
38499830	The impact of DNA methylation on CTCF-mediated 3D genome organization Monteagudo-Sánchez, A, Noordermeer, D, Greenberg, MVC	Nat Struct Mol Biol	2024
16949368	CTCF-dependent chromatin insulator is linked to epigenetic remodeling Ishihara, K, Oshimura, M, Nakao, M	Mol Cell	2006