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KDM5B [nucleoplasm]
Stable Identifier
R-HSA-3215031
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific demethylase 5B, Cancer/testis antigen 31, CT31, Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, PLU-1, Retinoblastoma-binding protein 2 homolog 1, RBP2-H1, JARID1B, RBBP2H1, PLU1
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)
KDM5A-D [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
KDM5A-D demethylate Me3K5-histone H3 (Homo sapiens)
KDM5A-D [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)
KDM5B:Fe2+ [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of cell cycle factors (Homo sapiens)
CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
KDM5B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UGL1 KDM5B
Gene Names
KDM5B, JARID1B, PLU1, RBBP2H1
Chain
chain:1-1544
Reference Genes
BioGPS Gene:10765 KDM5B
COSMIC (genes):KDM5B KDM5B
CTD Gene:10765 KDM5B
dbSNP Gene:10765 KDM5B
ENSEMBL:ENSG00000117139 KDM5B
ENSEMBL_homo_sapiens_GENE:ENSG00000117139.18 KDM5B
HGNC:18039 KDM5B
KEGG Gene (Homo sapiens):10765 KDM5B
Monarch:10765 KDM5B
NCBI Gene:10765 KDM5B
OMIM:605393 KDM5B
UCSC:Q9UGL1 KDM5B
Reference Transcript
RefSeq:NM_006618.4 KDM5B
RefSeq:NM_001314042.1 KDM5B
Other Identifiers
10765
11719928_a_at
11719929_a_at
11749455_a_at
11758815_a_at
16698049
201548_PM_s_at
201548_s_at
201549_PM_x_at
201549_x_at
211202_PM_s_at
211202_s_at
235285_PM_at
235285_at
2451303
2451305
2451307
2451308
2451310
2451311
2451312
2451313
2451314
2451315
2451320
2451323
2451325
2451326
2451327
2451328
2451329
2451330
2451333
2451334
2451335
2451336
2451337
2451338
2451339
2451340
2451341
2451343
2451344
2451346
2451348
2451349
2451351
2451352
2451353
2451354
2451362
2451363
2451364
2451366
2451374
2451375
2451376
2451377
39713_at
48383_at
7923453
A_23_P1038
A_32_P70724
A_33_P3276455
GE55277
GE656811
GO:0000785
GO:0003676
GO:0003677
GO:0003714
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007338
GO:0008270
GO:0009791
GO:0010628
GO:0016491
GO:0022414
GO:0023052
GO:0030154
GO:0032452
GO:0032453
GO:0033601
GO:0034647
GO:0036211
GO:0042393
GO:0043226
GO:0044344
GO:0045892
GO:0046872
GO:0048511
GO:0048856
GO:0050886
GO:0051213
GO:0060444
GO:0060763
GO:0060992
GO:0061038
GO:0070306
GO:0140096
GO:0140110
GO:0141052
GO:1990830
GO:1990837
GO:2000864
HMNXSV003016270
Hs.143323.0.S1_3p_s_at
Hs.143323.0.S2_3p_a_at
Hs.18891.0.S1_3p_at
ILMN_1755727
PH_hs_0008434
TC01003706.hg
g4322487_3p_a_at
Participates
as a component of
KDM5B:Fe2+ [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
as a member of
KDM5A-D [nucleoplasm] (Homo sapiens)
as an input of
TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
Inferred To
Kdm5b [nucleoplasm]
(Mus musculus)
Kdm5b [nucleoplasm]
(Rattus norvegicus)
Homologues of KDM5B [nucleoplasm]
(Schizosaccharomyces pombe)
KDM5B [nucleoplasm]
(Bos taurus)
KDM5B [nucleoplasm]
(Caenorhabditis elegans)
KDM5B [nucleoplasm]
(Canis familiaris)
KDM5B [nucleoplasm]
(Danio rerio)
KDM5B [nucleoplasm]
(Drosophila melanogaster)
KDM5B [nucleoplasm]
(Gallus gallus)
KDM5B [nucleoplasm]
(Saccharomyces cerevisiae)
KDM5B [nucleoplasm]
(Schizosaccharomyces pombe)
KDM5B [nucleoplasm]
(Sus scrofa)
rbbB [nucleoplasm]
(Dictyostelium discoideum)
lid2 [nucleoplasm]
(Schizosaccharomyces pombe)
msc1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001300971.1
,
NP_006609.3
Guide to Pharmacology - Targets
2681
OpenTargets
ENSG00000117139
GeneCards
Q9UGL1
HPA
ENSG00000117139-KDM5B
Ensembl
ENSP00000356233
,
ENST00000367265
,
ENST00000367264
,
ENSG00000117139
,
ENSP00000356234
PRO
Q9UGL1
Pharos - Targets
Q9UGL1
Orphanet
24643
PDB
5FZE
,
5FY5
,
5FZC
,
5FZI
,
5FZG
,
5A3P
,
5FZ8
,
6H4Z
,
5A3W
,
5FZA
,
5FPL
,
5LWB
,
5FYU
,
6H51
,
6EJ0
,
5FZ0
,
5FYS
,
6EIU
,
2MNZ
,
5FZ6
,
5FYY
,
5FZ3
,
5FZM
,
5FZK
,
5FUP
,
5FZF
,
5FY9
,
5FPU
,
5FZD
,
5FZH
,
2MA5
,
5FZ9
,
5A3N
,
5FZ7
,
5FY4
,
5FZB
,
6EIY
,
5A3T
,
5FZ1
,
5LW9
,
6H52
,
5FYT
,
6EJ1
,
5FV3
,
6RBI
,
5FYZ
,
2MNY
,
5FZ4
,
5A1F
,
5FYV
,
6EIN
,
6H50
,
5FZL
,
5FYB
,
6EK6
,
5FUN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49711 CTCF
1
CTCF [nucleoplasm]
(R-HSA-3782562)
0.524
8
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