Reactome | FPR1 [plasma membrane]

FPR1 [plasma membrane]

Stable Identifier

R-HSA-375450

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Formyl peptide receptor, fMet-Leu-Phe receptor, FPR1_HUMAN, FPR

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P21462 FPR1

Gene Names

FPR1

Chain

chain:1-350

Reference Genes

BioGPS Gene:2357 FPR1

COSMIC (genes):FPR1 FPR1

CTD Gene:2357 FPR1

dbSNP Gene:2357 FPR1

ENSEMBL:ENSG00000171051 FPR1

ENSEMBL:ENSG00000171051.10 FPR1

HGNC:3826 FPR1

KEGG Gene (Homo sapiens):2357 FPR1

Monarch:2357 FPR1

NCBI Gene:2357 FPR1

OMIM:136537 FPR1

UCSC:P21462 FPR1

Reference Transcript

Other Identifiers

11758095_s_at

11762622_at

16874945

205118_PM_at

205118_at

205119_PM_s_at

205119_s_at

2357

36919_r_at

3729270

3869238

3869239

3869240

3869241

3869242

3869243

3869244

3869245

3869246

3869247

3869248

3869258

8038899

GE61934

GO:0001664

GO:0002376

GO:0002430

GO:0004875

GO:0004930

GO:0004982

GO:0005124

GO:0005515

GO:0005737

GO:0005764

GO:0005773

GO:0005886

GO:0006935

GO:0006954

GO:0007165

GO:0007186

GO:0007188

GO:0007200

GO:0007204

GO:0007263

GO:0016020

GO:0023052

GO:0030667

GO:0031410

GO:0035577

GO:0043226

GO:0050786

GO:0060089

GO:0101003

HMNXSV003007608

ILMN_2092118

M60626_at

PH_hs_0028688

PH_hs_0035311

TC19001787.hg

g4503778_3p_a_at

Participates

as a member of

as an input of

FPR is a receptor for formyl peptides (Homo sapiens)

as a component of

FPR1:FMLP [plasma membrane] (Homo sapiens)

Other forms of this molecule

FPR1 [ficolin-1-rich granule membrane]

FPR1 [azurophil granule membrane]

FPR1 [secretory granule membrane]

Inferred To

FPR1 [plasma membrane] (Canis familiaris)

FPR1 [plasma membrane] (Danio rerio)

FPR1 [plasma membrane] (Gallus gallus)

FPR1 [plasma membrane] (Xenopus tropicalis)

LOC100489149 [plasma membrane] (Xenopus tropicalis)

LOC100491504 [plasma membrane] (Xenopus tropicalis)

Fpr1 [plasma membrane] (Mus musculus)

Fpr1 [plasma membrane] (Rattus norvegicus)

LOC108648117 [plasma membrane] (Xenopus tropicalis)

Homologues of FPR1 [plasma membrane] (Danio rerio)

Homologues of FPR1 [plasma membrane] (Xenopus tropicalis)

LOC101732071 [plasma membrane] (Xenopus tropicalis)

LOC100491339 [plasma membrane] (Xenopus tropicalis)

LOC116412268 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002020.1, NP_001180235.1

ZINC - World Drugs

FPR1_HUMAN

Guide to Pharmacology - Targets

222

OpenTargets

ENSG00000171051

ZINC - Substances

FPR1_HUMAN

ZINC target

P21462

PRO

P21462

PDB

7VFX, 7T6T, 7EUO, 7WVU

GeneCards

P21462

HPA

ENSG00000171051-FPR1

Ensembl

ENST00000594900, ENST00000304748, ENSP00000472936, ENSP00000471493, ENSP00000470750, ENSG00000171051, ENSP00000302707, ENST00000595042, ENST00000600815

Pharos - Targets

P21462

Orphanet

23728

ZINC - Predictions - Purchasable

FPR1_HUMAN

HMDB Protein

HMDBP02151

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15264 MAPK13	2	p-T180,Y182-MAPK13 [cytosol] (R-HSA-171022) MAPK13 [cytosol] (R-HSA-171012)	0.499	3
UniProt:P25098 GRK2	4	p-S29-ADRBK1 [cytosol] (R-HSA-9645318) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) GRK2 [plasma membrane] (R-HSA-50270)	0.499	3