Reactome | COG1 [Golgi membrane]

COG1 [Golgi membrane]

Stable Identifier

R-HSA-6808721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG1 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG1 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WTW3 COG1

Gene Names

COG1, KIAA1381, LDLB

Chain

initiator methionine:, chain:2-980

Reference Genes

BioGPS Gene:9382 COG1

COSMIC (genes):COG1 COG1

CTD Gene:9382 COG1

dbSNP Gene:9382 COG1

ENSEMBL:ENSG00000166685 COG1

ENSEMBL_homo_sapiens_GENE:ENSG00000166685.13 COG1

HGNC:6545 COG1

KEGG Gene (Homo sapiens):9382 COG1

Monarch:9382 COG1

NCBI Gene:9382 COG1

OMIM:606973 COG1

UCSC:Q8WTW3 COG1

Reference Transcript

RefSeq:NM_018714.2 COG1

Other Identifiers

11726713_a_at

11754508_a_at

16837433

227784_PM_s_at

227784_s_at

3733943

3733944

3733945

3733952

3733953

3733954

3733955

3733956

3733957

3733958

3733959

3733960

3733961

3733962

3733965

3733969

3733970

3733974

3733979

3733980

54861_s_at

54864_r_at

8009533

9382

A_23_P50020

A_33_P3372580

GE542612

GO:0000139

GO:0000301

GO:0005515

GO:0005794

GO:0006891

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0043226

GO:0070085

HMNXSV003045654

Hs.283109.4.A1_3p_a_at

ILMN_1791873

PH_hs_0014607

TC17000822.hg

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG1 [trans-Golgi network membrane]

Inferred To

COG1 [Golgi membrane] (Bos taurus)

COG1 [Golgi membrane] (Canis familiaris)

COG1 [Golgi membrane] (Gallus gallus)

COG1 [Golgi membrane] (Sus scrofa)

cogc-1 [Golgi membrane] (Caenorhabditis elegans)

Cog1 [Golgi membrane] (Drosophila melanogaster)

Cog1 [Golgi membrane] (Mus musculus)

Cog1 [Golgi membrane] (Rattus norvegicus)

cog1 [Golgi membrane] (Dictyostelium discoideum)

cog1 [Golgi membrane] (Schizosaccharomyces pombe)

cog1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_061184.1

OpenTargets

ENSG00000166685

GeneCards

Q8WTW3

HPA

ENSG00000166685-COG1

Ensembl

ENSG00000166685, ENST00000299886, ENSP00000299886

PRO

Q8WTW3

Pharos - Targets

Q8WTW3

Orphanet

17983

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