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UFL1 [cytosol]
Stable Identifier
R-HSA-5688970
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="14"E3 UFM1-protein ligase 1 ecNumber evidence="3"6.3.2.-/ecNumber, UFL1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UFL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94874 UFL1
Gene Names
UFL1, KIAA0776, MAXER, NLBP, RCAD
Chain
initiator methionine:, chain:2-794
Reference Genes
BioGPS Gene:23376 UFL1
COSMIC (genes):UFL1 UFL1
CTD Gene:23376 UFL1
dbSNP Gene:23376 UFL1
ENSEMBL:ENSG00000014123 UFL1
ENSEMBL_homo_sapiens_GENE:ENSG00000014123.10 UFL1
HGNC:23039 UFL1
KEGG Gene (Homo sapiens):23376 UFL1
Monarch:23376 UFL1
NCBI Gene:23376 UFL1
OMIM:613372 UFL1
UCSC:O94874 UFL1
Reference Transcript
RefSeq:NM_015323.4 UFL1
Other Identifiers
11743509_a_at
11743510_at
11751145_a_at
17011098
212633_PM_at
212633_at
212634_PM_at
212634_at
23376
2917915
2917916
2917919
2917921
2917923
2917925
2917926
2917928
2917929
2917930
2917932
2917934
2917936
2917938
2917939
2917941
2917942
2917943
2917944
2917945
2917946
2917947
2917948
2917949
2917950
36474_at
49793_at
8121161
A_23_P30956
GE56570
GO:0000077
GO:0001649
GO:0002376
GO:0003824
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005829
GO:0006281
GO:0006351
GO:0006355
GO:0006914
GO:0006954
GO:0006974
GO:0008284
GO:0010468
GO:0010508
GO:0012501
GO:0016020
GO:0016740
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030218
GO:0031397
GO:0032088
GO:0032434
GO:0032880
GO:0032991
GO:0033146
GO:0034976
GO:0035861
GO:0036211
GO:0043005
GO:0043066
GO:0043122
GO:0043226
GO:0048856
GO:0050727
GO:0060218
GO:0060252
GO:0061666
GO:0061709
GO:0071568
GO:0071569
GO:0140096
GO:1902065
GO:1903895
GO:1990592
HMNXSV003005701
Hs.5460.0.S1_3p_at
Hs.5460.0.S2_3p_at
ILMN_2058975
TC06000819.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
ufl-1 [cytosol]
(Caenorhabditis elegans)
Ufl1 [cytosol]
(Drosophila melanogaster)
Ufl1 [cytosol]
(Mus musculus)
Ufl1 [cytosol]
(Rattus norvegicus)
UFL1 [cytosol]
(Bos taurus)
UFL1 [cytosol]
(Canis familiaris)
UFL1 [cytosol]
(Dictyostelium discoideum)
UFL1 [cytosol]
(Gallus gallus)
UFL1 [cytosol]
(Sus scrofa)
ufl1 [cytosol]
(Danio rerio)
ufl1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_056138.1
OpenTargets
ENSG00000014123
GeneCards
O94874
HPA
ENSG00000014123-UFL1
Ensembl
ENST00000369278
,
ENSP00000358283
,
ENSG00000014123
PRO
O94874
Pharos - Targets
O94874
PDB
8OJ5
,
8QFD
,
8B9X
,
8C0D
,
8OJ8
,
8OJ0
,
8OHD
,
8QFC
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