Reactome | TUBGCP4 [cytosol]

TUBGCP4 [cytosol]

Stable Identifier

R-HSA-379268

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GCP-4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        TUBGCP4 [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        TUBGCP4 [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        TUBGCP4 [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        TUBGCP4 [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        TUBGCP4 [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        TUBGCP4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UGJ1 TUBGCP4

Gene Names

TUBGCP4, 76P, GCP4

Chain

chain:1-667

Reference Genes

BioGPS Gene:27229 TUBGCP4

COSMIC (genes):TUBGCP4 TUBGCP4

CTD Gene:27229 TUBGCP4

dbSNP Gene:27229 TUBGCP4

ENSEMBL:ENSG00000137822 TUBGCP4

HGNC:16691 TUBGCP4

KEGG:hsa:27229 TUBGCP4

Monarch:27229 TUBGCP4

NCBI Gene:27229 TUBGCP4

OMIM:609610 TUBGCP4

UCSC:Q9UGJ1 TUBGCP4

Reference Transcript

Participates

as a component of

gamma-tubulin complex [cytosol] (Homo sapiens)

Inferred To

TUBGCP4 [cytosol] (Bos taurus)

TUBGCP4 [cytosol] (Canis familiaris)

TUBGCP4 [cytosol] (Gallus gallus)

TUBGCP4 [cytosol] (Sus scrofa)

tubgcp4 [cytosol] (Xenopus tropicalis)

Tubgcp4 [cytosol] (Mus musculus)

Tubgcp4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001273343.1, XP_011519757.1, NP_055259.2

OpenTargets

ENSG00000137822

ENSEMBL

ENSG00000137822, ENSP00000260383, ENST00000260383, ENST00000564079, ENSP00000456648

HPA

ENSG00000137822-TUBGCP4

GeneCards

TUBGCP4

PRO

Q9UGJ1

Pharos - Targets

Q9UGJ1

Orphanet

TUBGCP4

GlyGen

Q9UGJ1

PDB

8RX1, 7QJC, 7QJA, 7QJB, 8VRD, 7QJ9, 7AS4, 7QJD, 7QJ5, 7QJ7, 7QJ6, 7QJ4, 7QJ8, 8VRK, 7QJ3, 7QJ1, 8VRJ, 7QJ0, 7QJ2, 3RIP, 7QJE, 6V69, 6V6S, 8Q62

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
UniProt:P21462 FPR1	4	FPR1 [plasma membrane] (R-HSA-375450) FPR1 [azurophil granule membrane] (R-HSA-6799143) FPR1 [secretory granule membrane] (R-HSA-6800929) FPR1 [ficolin-1-rich granule membrane] (R-HSA-6800878)	0.527	2
UniProt:Q8TES7 FBF1	1	FBF1 [cytosol] (R-HSA-5620933)	0.488	2
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.488	2