Reactome | ANK3 [cytosol]

ANK3 [cytosol]

Stable Identifier

R-HSA-374562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ankyrin-R, ANK3_HUMAN, Ankyrin-3

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        Ankyrin [cytosol] (Homo sapiens)
        
        ANK3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12955 ANK3

Gene Names

ANK3

Chain

chain:1-4377

Reference Genes

BioGPS Gene:288 ANK3

COSMIC (genes):ANK3 ANK3

CTD Gene:288 ANK3

dbSNP Gene:288 ANK3

ENSEMBL:ENSG00000151150 ANK3

HGNC:494 ANK3

KEGG:hsa:288 ANK3

Monarch:288 ANK3

NCBI Gene:288 ANK3

OMIM:600465 ANK3

UCSC:Q12955 ANK3

Reference Transcript

Participates

as a candidate of

ANK1-3 [cytosol] (Homo sapiens)

as a member of

Ankyrin [cytosol] (Homo sapiens)

as an input of

CDH1:CTNNB1,JUP complex binds to ANK3 (Homo sapiens)

as a component of

Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:ANK3 [Golgi membrane] (Homo sapiens)

Inferred To

tnks2 [cytosol] (Xenopus tropicalis)

Ank [cytosol] (Drosophila melanogaster)

ANK3 [cytosol] (Dictyostelium discoideum)

Homologues of ANK3 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_066267.2, NP_001191333.1, NP_001140.2, NP_001191332.1

OpenTargets

ENSG00000151150

ENSEMBL

ENST00000503366, ENSP00000280772, ENSG00000151150, ENSP00000347436, ENSP00000362933, ENST00000355288, ENSP00000425236, ENST00000373827, ENST00000280772

HPA

ENSG00000151150-ANK3

GeneCards

ANK3

PRO

Q12955

Pharos - Targets

Q12955

Orphanet

ANK3

GlyGen

Q12955

PDB

4O6X

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.573	2
UniProt:Q13610 PWP1			0.527	2
UniProt:Q86WR7 PRSR2			0.527	2
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.527	3
UniProt:Q9Y2D5 PLAK2			0.527	3
UniProt:O00203-1 AP3B1			0.527	2
UniProt:Q9UQF2 JIP1			0.527	3
UniProt:O00533 CHL1	1	CHL1 [plasma membrane] (R-HSA-443615)	0.527	2
UniProt:Q99689 FEZ1			0.527	2
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.527	2
UniProt:Q0ZGT2 NEXN			0.527	2
UniProt:Q92565 RPGF5			0.499	2

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