Reactome | SKIL [nucleoplasm]

SKIL [nucleoplasm]

Stable Identifier

R-HSA-2186596

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SNO, Ski-like protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12757 SKIL

Gene Names

SKIL, SNO

Chain

chain:1-684

Reference Genes

BioGPS Gene:6498 SKIL

COSMIC (genes):SKIL SKIL

CTD Gene:6498 SKIL

dbSNP Gene:6498 SKIL

ENSEMBL:ENSG00000136603 SKIL

HGNC:10897 SKIL

KEGG:hsa:6498 SKIL

Monarch:6498 SKIL

NCBI Gene:6498 SKIL

OMIM:165340 SKIL

UCSC:P12757 SKIL

Reference Transcript

Participates

as a member of

SKI/SKIL [nucleoplasm] (Homo sapiens)

Inferred To

skilb [nucleoplasm] (Danio rerio)

Skil [nucleoplasm] (Mus musculus)

Skil [nucleoplasm] (Rattus norvegicus)

skil [nucleoplasm] (Xenopus tropicalis)

SKIL [nucleoplasm] (Bos taurus)

SKIL [nucleoplasm] (Canis familiaris)

SKIL [nucleoplasm] (Gallus gallus)

SKIL [nucleoplasm] (Sus scrofa)

Snoo [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_006713798.1, NP_005405.2, NP_001138570.1, XP_005247778.1, NP_001138569.1, NP_001234937.1

OpenTargets

ENSG00000136603

ENSEMBL

ENSP00000259119, ENST00000458537, ENST00000426052, ENSG00000136603, ENST00000259119, ENSP00000516712, ENSP00000400193, ENSP00000406520, ENSP00000415243, ENST00000413427, ENST00000465590

HPA

ENSG00000136603-SKIL

GeneCards

SKIL

PRO

P12757

Pharos - Targets

P12757

GlyGen

P12757

PDB

3EQ5, 5C4V

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.738	6
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.718	6
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P08670 VIM	12	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) p39-VIM [cytosol] (R-HSA-9948102)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:Q53HV7 SMUG1	1	SMUG1 [nucleoplasm] (R-HSA-110161)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.547	3
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	2

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