Reactome | LEMD3 [endoplasmic reticulum membrane]

LEMD3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9714458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

MAN1

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11766875	Inner nuclear membrane proteins: functions and targeting Holmer, L, Worman, HJ	Cell Mol Life Sci	2001

External Reference Information

External Reference

UniProt:Q9Y2U8 LEMD3

Gene Names

LEMD3, MAN1

Chain

initiator methionine:, chain:2-911

Reference Genes

BioGPS Gene:23592 LEMD3

COSMIC (genes):LEMD3 LEMD3

CTD Gene:23592 LEMD3

dbSNP Gene:23592 LEMD3

ENSEMBL:ENSG00000174106 LEMD3

HGNC:28887 LEMD3

KEGG:hsa:23592 LEMD3

Monarch:23592 LEMD3

NCBI Gene:23592 LEMD3

OMIM:607844 LEMD3

UCSC:Q9Y2U8 LEMD3

Reference Transcript

Other Identifiers

11721227_at

11721228_s_at

11721229_at

16753588

218604_PM_at

218604_at

23592

3420090

3420091

3420092

3420093

3420094

3420095

3420096

3420097

3420098

3420099

3420100

3420101

3420102

3420103

3420116

3420117

3420118

3420120

3420121

3420128

3420129

3420130

3420131

3420132

3420134

3420136

3420137

3420138

3420139

3420140

3420141

3420142

3420146

3420148

3420150

54159_at

72884_at

7956842

A_14_P121448

A_23_P151018

A_33_P3382709

GE58578

GO:0003676

GO:0003677

GO:0005515

GO:0005634

GO:0005637

GO:0012505

GO:0016020

GO:0030512

GO:0030514

GO:0031965

GO:0031967

GO:0032926

GO:0043226

GO:1990446

HMNXSV003045627

ILMN_1727361

ILMN_2183938

PH_hs_0029077

TC12000581.hg

g7706606_3p_at

Participates

as a candidate of

Other forms of this molecule

LEMD3 [endosome membrane]

LEMD3 [plasma membrane]

LEMD3 [nuclear envelope]

Inferred To

rbm39 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Rbm39 [endoplasmic reticulum membrane] (Mus musculus)

Rbm39 [endoplasmic reticulum membrane] (Rattus norvegicus)

RBM23 [endoplasmic reticulum membrane] (Gallus gallus)

RBM39 [endoplasmic reticulum membrane] (Bos taurus)

RBM39 [endoplasmic reticulum membrane] (Canis familiaris)

RBM39 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_055134.2, NP_001161086.1

ENSEMBL

ENST00000308330, ENSP00000308369

OpenTargets

ENSG00000174106

HPA

ENSG00000174106-LEMD3

PRO

Q9Y2U8

Pharos - Targets

Q9Y2U8

GlyGen

Q9Y2U8

Orphanet

LEMD3

HMDB Protein

HMDBP14557

PDB

5ZOJ, 5ZOK, 2CH0

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.669	4
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.564	3
UniProt:Q8BUN5 Smad3	10	Ub-SMAD3 [cytosol] (R-MMU-6782830) Smad3 [nucleoplasm] (R-MMU-4006003) phospho-p-S208-SMAD3 [cytosol] (R-MMU-9731114) SMAD3 [nucleoplasm] (R-MMU-206150) phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-MMU-2187326) phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-MMU-9773841) phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (R-MMU-2176471) SMAD3 [cytosol] (R-MMU-170855) p-S423,425-Smad3 [cytosol] (R-MMU-9605416) p-S423,425-Smad3 [nucleoplasm] (R-MMU-1225907)	0.564	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:O75106 AOC2	1	AOC2 [plasma membrane] (R-HSA-5696150)	0.527	2
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.483	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.483	3

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