Reactome | LEMD3 [endoplasmic reticulum membrane]

LEMD3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9714458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

MAN1

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11766875	Inner nuclear membrane proteins: functions and targeting Holmer, L, Worman, HJ	Cell Mol Life Sci	2001

External Reference Information

External Reference

UniProt:Q9Y2U8 LEMD3

Gene Names

LEMD3, MAN1

Chain

initiator methionine:1, chain:2-911

Reference Genes

BioGPS Gene:23592 LEMD3

COSMIC (genes):LEMD3 LEMD3

CTD Gene:23592 LEMD3

dbSNP Gene:23592 LEMD3

ENSEMBL:ENSG00000174106 LEMD3

ENSEMBL:ENSG00000174106.3 LEMD3

HGNC:28887 LEMD3

KEGG Gene (Homo sapiens):23592 LEMD3

Monarch:23592 LEMD3

NCBI Gene:23592 LEMD3

OMIM:607844 LEMD3

UCSC:Q9Y2U8 LEMD3

Reference Transcript

Other Identifiers

11721227_at

11721228_s_at

11721229_at

16753588

218604_PM_at

218604_at

23592

3420091

3420092

3420093

3420094

3420095

3420096

3420097

3420098

3420099

3420100

3420101

3420102

3420103

3420116

3420120

3420121

3420128

3420129

3420130

3420131

3420132

3420134

3420136

3420137

3420139

3420140

3420141

3420142

54159_at

72884_at

7956842

A_14_P121448

A_23_P151018

A_33_P3382709

GE58578

GO:0003676

GO:0003677

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0012505

GO:0016020

GO:0023052

GO:0030512

GO:0030514

GO:0031965

GO:0032926

GO:0043226

GO:1990446

HMNXSV003045627

ILMN_1727361

ILMN_2183938

PH_hs_0029077

TC12000581.hg

g7706606_3p_at

Participates

as a candidate of

Other forms of this molecule

LEMD3 [endosome membrane]

LEMD3 [plasma membrane]

LEMD3 [nuclear envelope]

Inferred To

Homologues of LEMD3 [endoplasmic reticulum membrane] (Danio rerio)

rnpc2 [endoplasmic reticulum membrane] (Danio rerio)

rbm39 [endoplasmic reticulum membrane] (Xenopus tropicalis)

LEMD3 [endoplasmic reticulum membrane] (Canis familiaris)

rnpc2l [endoplasmic reticulum membrane] (Danio rerio)

Rbm39 [endoplasmic reticulum membrane] (Mus musculus)

Rbm39 [endoplasmic reticulum membrane] (Rattus norvegicus)

RBM23 [endoplasmic reticulum membrane] (Gallus gallus)

RBM39 [endoplasmic reticulum membrane] (Bos taurus)

RBM39 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001161086.1, NP_055134.2

OpenTargets

ENSG00000174106

HPA

ENSG00000174106-LEMD3

GeneCards

Q9Y2U8

Ensembl

ENSG00000174106, ENSP00000308369, ENST00000308330

PRO

Q9Y2U8

Pharos - Targets

Q9Y2U8

Orphanet

16349

PDB

5ZOJ, 5ZOK, 2CH0

HMDB Protein

HMDBP14557

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8BUN5 Smad3	10	Ub-SMAD3 [cytosol] (R-MMU-6782830) Smad3 [nucleoplasm] (R-MMU-4006003) phospho-p-S208-SMAD3 [cytosol] (R-MMU-9731114) SMAD3 [nucleoplasm] (R-MMU-206150) phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-MMU-2187326) phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-MMU-9773841) phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (R-MMU-2176471) SMAD3 [cytosol] (R-MMU-170855) p-S423,425-Smad3 [cytosol] (R-MMU-9605416) p-S423,425-Smad3 [nucleoplasm] (R-MMU-1225907)	0.564	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.564	2

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