Reactome | 3x4Hyp-GlcGalHyl-COL1A1 [extracellular region]

3x4Hyp-GlcGalHyl-COL1A1 [extracellular region]

Stable Identifier

R-HSA-2089968

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of hemostasis (Homo sapiens)
  - Defects of platelet adhesion to exposed collagen (Homo sapiens)
    - Defective VWF binding to collagen type I (Homo sapiens)
      - VWF variant does not bind to collagen type I (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Defective VWF cleavage by ADAMTS13 variant (Homo sapiens)
      - ADAMTS13 variant does not cleave VWF multimer (Homo sapiens)
        
        Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Defective binding of VWF variant to GPIb:IX:V (Homo sapiens)
      - VWF variant does not bind GPIb:IX:V (Homo sapiens)
        
        VWF variant multimer:collagen type I fibril [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Enhanced binding of GP1BA variant to VWF multimer:collagen (Homo sapiens)
      - GP1BA variant binds to VWF multimer:collagen (Homo sapiens)
        
        Caplacizumab:VWF:collagen type I [extracellular region] (Homo sapiens)
        
        Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril:VWF multimer:GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Enhanced cleavage of VWF variant by ADAMTS13 (Homo sapiens)
      - ADAMTS13 cleaves VWF variant multimer (Homo sapiens)
        
        Collagen type I fibril:VWF variant multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril:cleaved VWF variant multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)

Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
    - Anchoring fibril formation (Homo sapiens)
      - Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)
        
        Anchoring fibril complex [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Crosslinking of collagen fibrils (Homo sapiens)
      - Formation of allysine by LOX (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with allysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without allysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with allysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without allysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)
        
        Collagen type 1 fibrils cross-linked by dehydro-lysinonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with dehydro-lysinonorleucine [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without deH-LNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with allysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without allysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of histidino-hydroxylysinonorleucine cross-links (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with histidino-hydroxylysinoleucine cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of hydroxyallysine by LOX (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of hydroxylysino-5-ketonorleucine cross-links (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with hydroxylysyl-pyridinoline cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxylysyl-pyridinoline cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without HL-Pyr [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of hydroxylysyl-pyrrole cross-links (Homo sapiens)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with hydroxylysyl-pyrrole cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxylysyl-pyrrole cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without HL-Pyrrole [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of lysyl-pyridinoline cross-links (Homo sapiens)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with lysyl-pyridinoline cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with lysyl-pyridinoline cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without L-Pyr [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Formation of lysyl-pyrrole cross-links (Homo sapiens)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
        
        Collagen type I fibril with lysyl-pyrrole cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen type I with or without L-Pyrrole [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Formation of collagen fibres (Homo sapiens)
      - Collagen fibres [extracellular region] (Homo sapiens)
        
        Collagen type I fibre [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Collagen fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Formation of collagen fibrils (Homo sapiens)
      - Collagen fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Type XII and XIV collagens associate with type I and type II fibrils (Homo sapiens)
      - Collagen type I, II fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Collagen type I,II:XII,XIV fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I, II fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Collagen biosynthesis and modifying enzymes (Homo sapiens)
    - Removal of fibrillar collagen C-propeptides (Homo sapiens)
      - Tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- Degradation of the extracellular matrix (Homo sapiens)
  - Collagen degradation (Homo sapiens)
    - Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I degradation by MMP14 (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I degradation by MMP15 (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- ECM proteoglycans (Homo sapiens)
  - BGN binds Collagen types I, VI, (IX) (Homo sapiens)
    - BGN:Collagen types I, VI, (IX) [extracellular region] (Homo sapiens)
      - Collagen types I, VI, (IX) [extracellular region] (Homo sapiens)
        
        Collagen type I fibre [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen types I, VI, (IX) [extracellular region] (Homo sapiens)
      - Collagen type I fibre [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)
    - COMP interactors [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - COMP pentamer:COMP interactors [extracellular region] (Homo sapiens)
      - COMP interactors [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - DCN binds collagen I, II, III, VI fibrils (Homo sapiens)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Homo sapiens)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - IBSP binds collagen type I (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - IBSP:Collagen type I fibril [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - VTN binds collagens I, IV and VI (Homo sapiens)
    - Collagen type I,IV,VI [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - VTN:Collagen type I,IV,VI [extracellular region] (Homo sapiens)
      - Collagen type I,IV,VI [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- FN1 binds Collagen types I-V, VII (Homo sapiens)
  - Collagen types I-V, VII [extracellular region] (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Homo sapiens)
    - Collagen types I-V, VII [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- Integrin cell surface interactions (Homo sapiens)
  - Collagen type I binds integrin alpha11beta1 (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- Non-integrin membrane-ECM interactions (Homo sapiens)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Homo sapiens)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Homo sapiens)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Syndecan interactions (Homo sapiens)
    - Syndecan-1 binds collagen types I, III, V (Homo sapiens)
      - Collagen types I, III, V [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Syndecan-1:Collagen types I, III, V [plasma membrane] (Homo sapiens)
        
        Collagen types I, III, V [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- Platelet Adhesion to exposed collagen (Homo sapiens)
  - ADAMTS13 cleaves VWF multimer (Homo sapiens)
    - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I fibril:cleaved VWF multimer [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Caplacizumab binds VWF (Homo sapiens)
    - Caplacizumab:VWF:collagen type I [extracellular region] (Homo sapiens)
      - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - GPIb:IX:V binds to VWF multimer:collagen (Homo sapiens)
    - Caplacizumab:VWF:collagen type I [extracellular region] (Homo sapiens)
      - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I fibril:cleaved VWF multimer [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GP1BA:GP1BB:GP9:GP5:VWF:collagen type I [plasma membrane] (Homo sapiens)
      - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - VWF multimer binds to collagen type I (Homo sapiens)
    - Collagen type I fibril [extracellular region] (Homo sapiens)
      - Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Collagen type I fibril:VWF multimer [extracellular region] (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - GP1b-IX-V activation signalling (Homo sapiens)
    - GP1b signaling involves c-Src (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GP1b-IX-V binds filamin (Homo sapiens)
      - GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Homo sapiens)
        
        GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)
      - Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - vWF binds to collagen (Homo sapiens)
      - Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - GPVI-mediated activation cascade (Homo sapiens)
    - Binding of Syk tyrosine kinase (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - GPVI stimulates PI3K beta, gamma (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - SYK autophosphorylates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - p-Y348-SYK dissociates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Thrombin binding to GP1b:IX:V (Homo sapiens)
      - GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - LAIR2 binds collagen (Homo sapiens)
      - Collagen types I,III [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - LAIR2:Collagen type I,III [extracellular region] (Homo sapiens)
        
        Collagen types I,III [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
    - OSCAR binds collagen and SP-D (Homo sapiens)
      - Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
        
        Collagen fibres [extracellular region] (Homo sapiens)
        
        Collagen type I fibre [extracellular region] (Homo sapiens)
        
        Collagen type I fibril [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging by Class A Receptors (Homo sapiens)
    - MSR1 (SCARA1) binds collagen (Homo sapiens)
      - Denatured Collagen I,III, Collagen IV [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)
      - MSR1:Collagen I,III,IV [extracellular region] (Homo sapiens)
        
        Denatured Collagen I,III, Collagen IV [extracellular region] (Homo sapiens)
        
        Tropocollagen type I [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02452 COL1A1

Gene Names

COL1A1

Chain

signal peptide:1-22, propeptide:23-161, chain:162-1218, propeptide:1219-1464

Reference Genes

BioGPS Gene:1277 COL1A1

COSMIC (genes):COL1A1 COL1A1

CTD Gene:1277 COL1A1

dbSNP Gene:1277 COL1A1

ENSEMBL:ENSG00000108821 COL1A1

ENSEMBL_homo_sapiens_GENE:ENSG00000108821.14 COL1A1

HGNC:2197 COL1A1

KEGG Gene (Homo sapiens):1277 COL1A1

Monarch:1277 COL1A1

NCBI Gene:1277 COL1A1

OMIM:120150 COL1A1

UCSC:P02452 COL1A1

Reference Transcript

RefSeq:NM_000088.3 COL1A1

Other Identifiers

11715350_a_at

11715351_at

11715352_x_at

11746872_a_at

1277

1556499_PM_s_at

1556499_s_at

16846587

202310_PM_s_at

202310_s_at

202311_PM_s_at

202311_s_at

202312_PM_s_at

202312_s_at

217430_3p_x_at

217430_PM_x_at

217430_x_at

35473_at

35474_s_at

3762199

3762200

3762201

3762202

3762203

3762204

3762206

3762207

3762208

3762210

3762211

3762212

3762213

3762214

3762215

3762216

3762217

3762218

3762220

3762221

3762222

3762223

3762225

3762226

3762227

3762228

3762229

3762231

3762232

3762234

3762235

3762236

3762238

3762239

3762241

3762242

3762243

3762244

3762245

3762246

3762247

3762249

3762250

3762251

3762252

3762253

3762254

3762256

3762257

3762258

3762259

3762260

3762262

3762263

3762264

3762265

3762266

3762267

3762268

3762269

3762270

8016646

A_33_P3304668

GE60433

GE80888

GO:0001501

GO:0001503

GO:0001568

GO:0001649

GO:0001957

GO:0001958

GO:0002020

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005581

GO:0005584

GO:0005615

GO:0005737

GO:0005783

GO:0005788

GO:0006351

GO:0006355

GO:0007155

GO:0007584

GO:0007601

GO:0007605

GO:0009410

GO:0009612

GO:0010718

GO:0010812

GO:0014070

GO:0015031

GO:0023052

GO:0030020

GO:0030141

GO:0030154

GO:0030198

GO:0030199

GO:0030312

GO:0030335

GO:0031012

GO:0031410

GO:0031667

GO:0032355

GO:0032868

GO:0032964

GO:0034504

GO:0034505

GO:0038063

GO:0042542

GO:0042802

GO:0043226

GO:0043434

GO:0043588

GO:0043589

GO:0044344

GO:0045893

GO:0046872

GO:0048407

GO:0048545

GO:0048705

GO:0048706

GO:0048856

GO:0048870

GO:0050877

GO:0051591

GO:0055093

GO:0060325

GO:0060346

GO:0060351

GO:0062023

GO:0071230

GO:0071260

GO:0071300

GO:0071306

GO:0071333

GO:0071356

GO:0071364

GO:0071560

GO:0090263

GO:1902617

GO:1902618

HMNXSV003032746

Hs.172928.0.A1_3p_a_at

Hs.172928.0.A2_3p_a_at

Hs2.433191.1.A1_3p_s_at

ILMN_1701308

M55998_s_at

PH_hs_0010359

TC17001682.hg

Z74615_at

g4502944_3p_a_at

Participates

as a member of

Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)

Other forms of this molecule

3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]

Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]

Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]

Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl Collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrolysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region]

Hydroxylysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]

Lysino-5-ketonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region]

Lysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Lysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

3x4Hyp-3Hyp-Alys-COL1A1 [extracellular region]

Alys-COL1A1 [extracellular region]

3x4Hyp-Alys-COL1A1 [extracellular region]

Alys-GalHyl-COL1A1 [extracellular region]

3x4Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region]

3x4Hyp-3Hyp-5Hyl-Alys-COL1A1 [extracellular region]

3x4Hyp-5Hyl-Alys-COL1A1 [extracellular region]

3x4Hyp-3Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region]

Alys-GlcGalHyl-COL1A1 [extracellular region]

3x4Hyp-Alys-GalHyl-COL1A1 [extracellular region]

5Hyl-Alys-COL1A1 [extracellular region]

3x4Hyp-3Hyp-Alys-GalHyl-COL1A1 [extracellular region]

Dehydrohydroxylysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl Collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Dehydrohydroxylysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxylysino-5-ketonorlysyl 5-hydroxylysyl-collagen alpha-1(I) chain [extracellular region]

Hydroxyallysyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]

Hydroxyallysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

Hydroxyallysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [extracellular region]

GalHyl-COL1A1(23-1464) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region]

GlcGalHyl-COL1A1(23-1464) [extracellular region]

3x4Hyp-GalHyl-COL1A1(23-1464) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [extracellular region]

COL1A1(23-1464) [extracellular region]

3x4Hyp-3Hyp-COL1A1(23-1464) [extracellular region]

3x4Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region]

5Hyl-COL1A1(23-1464) [extracellular region]

3x4Hyp-5Hyl-COL1A1(23-1464) [extracellular region]

3x4Hyp-COL1A1(23-1464) [extracellular region]

3x4Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region]

3x4Hyp-GalHyl-COL1A1(162-1464) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL1A1(162-1464) [extracellular region]

3x4Hyp-5Hyl-COL1A1(162-1464) [extracellular region]

5Hyl-COL1A1(162-1464) [extracellular region]

GlcGalHyl-COL1A1(162-1464) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL1A1(162-1464) [extracellular region]

GalHyl-COL1A1(162-1464) [extracellular region]

3x4Hyp-COL1A1(162-1464) [extracellular region]

COL1A1(162-1464) [extracellular region]

3x4Hyp-3Hyp-COL1A1(162-1464) [extracellular region]

3x4Hyp-3Hyp-COL1A1(954-1218) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region]

GlcGalHyl-COL1A1(162-953) [extracellular region]

COL1A1(954-1218) [extracellular region]

3x4Hyp-GalHyl-COL1A1(162-953) [extracellular region]

3x4Hyp-GalHyl-COL1A1(954-1218) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region]

3x4Hyp-5Hyl-COL1A1(954-1218) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL1A1(954-1218) [extracellular region]

3x4Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region]

3x4Hyp-5Hyl-COL1A1(162-953) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL1A1(954-1218) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL1A1(162-953) [extracellular region]

GalHyl-COL1A1(954-1218) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL1A1(162-953) [extracellular region]

5Hyl-COL1A1(954-1218) [extracellular region]

3x4Hyp-COL1A1(162-953) [extracellular region]

3x4Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region]

GalHyl-COL1A1(162-953) [extracellular region]

GlcGalHyl-COL1A1(954-1218) [extracellular region]

COL1A1(162-953) [extracellular region]

3x4Hyp-COL1A1(954-1218) [extracellular region]

3x4Hyp-3Hyp-COL1A1(162-953) [extracellular region]

5Hyl-COL1A1(162-953) [extracellular region]

GlcGalHyl-COL1A1 [extracellular region]

3x4Hyp-GalHyl-COL1A1 [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL1A1 [extracellular region]

3x4Hyp-COL1A1 [extracellular region]

3x4Hyp-3Hyp-COL1A1 [extracellular region]

5Hyl-COL1A1 [extracellular region]

GalHyl-COL1A1 [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL1A1 [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL1A1 [extracellular region]

COL1A1 [extracellular region]

3x4Hyp-5Hyl-COL1A1 [extracellular region]

Inferred To

col1a1 [extracellular region] (Xenopus tropicalis)

col1a1b [extracellular region] (Danio rerio)

3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Bos taurus)

3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Mus musculus)

3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (Rattus norvegicus)

COL1A1 [extracellular region] (Canis familiaris)

COL1A1 [extracellular region] (Gallus gallus)

COL1A1 [extracellular region] (Sus scrofa)

cle-1 [extracellular region] (Caenorhabditis elegans)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

O5-glucosylgalactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-glucosylgalactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_000079.2

OpenTargets

ENSG00000108821

GeneCards

P02452

HPA

ENSG00000108821-COL1A1

Ensembl

ENSP00000225964, ENSG00000108821, ENST00000225964

PRO

P02452

Pharos - Targets

P02452

Orphanet

15767

HMDB Protein

HMDBP01757

PDB

5CVB, 5OU9, 2LLP, 3EJH, 7E7D, 5CVA, 5K31, 5CTI, 5CTD, 3GXE, 5OU8, 1Q7D, 7E7B

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.713	3
UniProt:Q02809 PLOD1	1	PLOD1 [endoplasmic reticulum membrane] (R-HSA-1981109)	0.643	3
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.623	3
UniProt:O01949 ALL3			0.598	5
UniProt:P08123 COL1A2	20	GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023602) 3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023558) GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023547) 3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023674) 3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023580) 3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2023663) 3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022070) 3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022501) 3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022977) 3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022966) 5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022455) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396490) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396080) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396375) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396493) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396241) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396064) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396361) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396431) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396174)	0.576	5
UniProt:O75718 CRTAP	1	CRTAP [endoplasmic reticulum lumen] (R-HSA-1980261)	0.576	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.576	3
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.558	3
UniProt:Q96HE7 ERO1A	1	ERO1L [endoplasmic reticulum lumen] (R-HSA-265076)	0.558	3
UniProt:P13667 PDIA4			0.558	3
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.558	3
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.558	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:Q8IYK4 COLGALT2	1	COLGALT2 [endoplasmic reticulum lumen] (R-HSA-1981122)	0.527	2
UniProt:Q5T124 UBXN11	1	UBXN11 [cytosol] (R-HSA-9696514)	0.527	2
UniProt:O43615 TIMM44	1	TIMM44(?-452) [mitochondrial inner membrane] (R-HSA-1252038)	0.527	2
UniProt:O75616 ERAL1	1	ERAL1 [mitochondrial matrix] (R-HSA-8932742)	0.527	2
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.527	2
UniProt:Q7Z624 CAMKMT	1	CAMKMT [cytosol] (R-HSA-6786199)	0.527	2
UniProt:P13674 P4HA1	1	P4HA1 [endoplasmic reticulum lumen] (R-HSA-2980917)	0.499	2
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.499	2
UniProt:Q8TBP6 S2540			0.499	2
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.499	2
UniProt:Q96AY3 FKB10			0.499	2
UniProt:Q8NBJ5 COLGALT1	1	COLGALT1 [endoplasmic reticulum lumen] (R-HSA-1981138)	0.499	2
UniProt:Q15293 RCN1	2	p-RCN1 [endoplasmic reticulum lumen] (R-HSA-8956989) RCN1 [endoplasmic reticulum lumen] (R-HSA-8956758)	0.499	2
UniProt:P30040 ERP29			0.499	2
UniProt:O00461 GOLIM4	2	GOLIM4 [transport vesicle] (R-HSA-8847524) GOLIM4 [Golgi membrane] (R-HSA-8847523)	0.499	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.499	2
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.499	2
UniProt:P23284 PPIB	2	PPIB [endoplasmic reticulum lumen] (R-HSA-1980262) PPIB [cytosol] (R-HSA-9728770)	0.499	2

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