Reactome | FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]

FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]

Stable Identifier

R-HSA-9713462

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Fibronectin, FINC_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
22570254	Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer Ren, H, Tan, ZP, Zhu, X, Crosby, K, Haack, H, Ren, JM, Beausoleil, S, Moritz, A, Innocenti, G, Rush, J, Zhang, Y, Zhou, XM, Gu, TL, Yang, YF, Comb, MJ	Cancer Res	2012

External Reference Information

External Reference

UniProt:P02751 FN1

Gene Names

FN1, FN

Chain

signal peptide:1-31, chain:32-2477, chain:627-702, chain:723-911, chain:723-903, chain:723-

Reference Genes

COSMIC (genes):FN1 FN1

dbSNP Gene:2335 FN1

ENSEMBL:ENSG00000115414 FN1

Participates

as a component of

FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

FN1(32-2477) [extracellular region]

FN1 [endoplasmic reticulum lumen]

p-FN1 [endoplasmic reticulum lumen]

FN1(32-2477) [platelet alpha granule lumen]

FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]

FN1(?-2386) [extracellular region]

FN1(32-?) [extracellular region]

FN1(272-2477) [extracellular region]

FN1(32-271) [extracellular region]

Modified Residues

Name

Insertion of residues 1022 to 1620 at 1202 from UniProt:Q9UM73 ALK

Coordinate

1202

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
ovarian carcinoma	DOID:4001	Ovarian carcinoma

Cross References

COSMIC

COSF1300

Mondo

0005140

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2477) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.891	8
ChEBI:28304 HEPARIN			0.845	6
UniProt:P08648 ITGA5	3	ITGA5(42-894) [plasma membrane] (R-HSA-202735) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5 [plasma membrane] (R-HSA-9857636)	0.839	11
UniProt:P21980 TGM2			0.811	5
UniProt:P14738 FNBA			0.789	23
UniProt:P05106 ITGB3	3	ITGB3 [plasma membrane] (R-HSA-57600) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107)	0.75	5
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.745	12
UniProt:Q53682 Q53682			0.743	19
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [plasma membrane] (R-HSA-210013) ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773)	0.743	4
UniProt:Q53971 Q53971			0.719	4
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.713	3
UniProt:Q93ED6 Q93ED6			0.675	8
IntAct:EBI-2528478 COLLAGEN			0.667	5
UniProt:P29279 CCN2	1	CTGF [extracellular region] (R-HSA-561148)	0.65	5
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.643	3
IntAct:EBI-2550721 INTG			0.623	3
UniProt:Q9CKF6 Q9CKF6			0.623	5
UniProt:P11684 UTER			0.618	3
UniProt:P07996 THBS1	5	THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) THBS1 [extracellular region] (R-HSA-66518) THBS1 [platelet alpha granule lumen] (R-HSA-114701)	0.609	2
UniProt:P07585 DCN	20	DCN(31-?) [extracellular region] (R-HSA-2534171) DCN(?-359) [extracellular region] (R-HSA-2534176) DCN [extracellular region] (R-HSA-1430775) dermatan-DCN [Golgi lumen] (R-HSA-5607522) D4,6S-DCN [Golgi lumen] (R-HSA-9941310) D2,4(S)2-DCN [Golgi lumen] (R-HSA-2065119) GlcA-Gal-Gal-Xyl-DCN [Golgi lumen] (R-HSA-2064161) GlcA-Gal-Gal-XylP-DCN [Golgi lumen] (R-HSA-9941359) Gal-Gal-Xyl-DCN [Golgi lumen] (R-HSA-2064064) Gal-Xyl-DCN [Golgi lumen] (R-HSA-2064080) XylS-DCN [Golgi lumen] (R-HSA-2064097) DCN [Golgi lumen] (R-HSA-2063995) chondroitin(1)-DCN [Golgi lumen] (R-HSA-2064248) chondroitin(2)-DCN [Golgi lumen] (R-HSA-2063993) chondroitin(3)-DCN [Golgi lumen] (R-HSA-2064025) C4S-DCN [Golgi lumen] (R-HSA-2064171) CSE-DCN [Golgi lumen] (R-HSA-2064056) C6S-DCN [Golgi lumen] (R-HSA-2064145) C2S6S-DCN [Golgi lumen] (R-HSA-9941143) C4S-DCN [extracellular region] (R-HSA-2064029)	0.602	9
UniProt:P08519 LPA	1	LPA [extracellular region] (R-HSA-176877)	0.592	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.564	3
UniProt:P98066 TNFAIP6	3	TNFAIP6 [ficolin-1-rich granule lumen] (R-HSA-6803311) TNFAIP6 [extracellular region] (R-HSA-6803348) TNFAIP6 [tertiary granule lumen] (R-HSA-6803341)	0.558	8
UniProt:P23568 EFTU			0.558	2
UniProt:P28300-PRO_0000018520 LOX			0.558	2
UniProt:Q4AAD6 Q4AAD6			0.558	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q15942 ZYX			0.547	2
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.547	2
UniProt:P05154 SERPINA5	1	SERPINA5 [extracellular region] (R-HSA-5591085)	0.544	3
UniProt:O75636 FCN3	1	FCN3 [extracellular region] (R-HSA-2530443)	0.544	3
UniProt:P17931 LGALS3	3	LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307)	0.527	3
UniProt:O95302 FKBP9	1	FKBP9 [cytosol] (R-HSA-391306)	0.527	2
UniProt:P50395 GDI2	4	GDI2 [cytosol] (R-HSA-195089) GDI2 [secretory granule lumen] (R-HSA-6800904) GDI2 [extracellular region] (R-HSA-6806176) GDI2 [azurophil granule lumen] (R-HSA-6799337)	0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:Q9BXJ1 C1QT1			0.527	2
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.527	2
UniProt:Q969J2 ZKSCAN4	1	ZKSCAN4 [nucleoplasm] (R-HSA-1027423)	0.527	2
UniProt:Q6ISS4 LAIR2	1	LAIR2 [extracellular region] (R-HSA-5696342)	0.527	2
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.527	2
UniProt:Q601D1 Q601D1			0.524	2
UniProt:Q9NY15 STAB1	2	STAB1 [endocytic vesicle membrane] (R-HSA-2239447) STAB1 [plasma membrane] (R-HSA-2197768)	0.508	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.506	2
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.499	2
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.491	2
UniProt:C5MHM7 C5MHM7			0.462	2
UniProt:C5MBE7 C5MBE7			0.462	2
UniProt:C5MAS1 C5MAS1			0.462	2
UniProt:G8BE22 G8BE22			0.462	2
UniProt:G8BA52 G8BA52			0.462	2
UniProt:G8B999 G8B999			0.462	2
UniProt:G8BCH3 G8BCH3			0.462	2

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