Reactome | P4HA1 [endoplasmic reticulum lumen]

P4HA1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-2980917

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Prolyl 4-hydroxylase subunit alpha-1, P4HA1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P13674 P4HA1

Gene Names

P4HA1, P4HA

Chain

signal peptide:1-17, chain:18-534

Reference Genes

BioGPS Gene:5033 P4HA1

COSMIC (genes):P4HA1 P4HA1

CTD Gene:5033 P4HA1

dbSNP Gene:5033 P4HA1

ENSEMBL:ENSG00000122884 P4HA1

ENSEMBL:ENSG00000122884.13 P4HA1

HGNC:8546 P4HA1

KEGG Gene (Homo sapiens):5033 P4HA1

Monarch:5033 P4HA1

NCBI Gene:5033 P4HA1

OMIM:176710 P4HA1

UCSC:P13674 P4HA1

Reference Transcript

Other Identifiers

11730853_s_at

16715361

207543_PM_s_at

207543_s_at

3294164

3294165

3294166

3294167

3294168

3294169

3294170

3294172

3294174

3294176

3294179

3294180

3294184

3294186

3294188

3294190

3294191

3294196

3294200

3294201

3294202

3294203

3294204

3294210

3309213

37037_at

3807499

3807500

5033

7895256

7895674

7934278

A_24_P406693

A_33_P3214481

GE57882

GO:0003824

GO:0004656

GO:0005506

GO:0005515

GO:0005581

GO:0005783

GO:0005788

GO:0016020

GO:0016222

GO:0016491

GO:0016705

GO:0018401

GO:0030198

GO:0030199

GO:0031418

GO:0036211

GO:0042802

GO:0043226

GO:0043231

GO:0046872

GO:0051213

GO:0140096

HMNXSV003040556

ILMN_1693334

ILMN_1747442

M24486_s_at

PH_hs_0004428

TC10001398.hg

g4505564_3p_a_at

Participates

as a member of

Prolyl 4-hydroxylase alpha subunits [endoplasmic reticulum lumen] (Homo sapiens)

Inferred To

p4ha1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

SI:zC146F4.4 [endoplasmic reticulum lumen] (Danio rerio)

P4HA1 [endoplasmic reticulum lumen] (Bos taurus)

P4HA1 [endoplasmic reticulum lumen] (Canis familiaris)

P4HA1 [endoplasmic reticulum lumen] (Gallus gallus)

P4HA1 [endoplasmic reticulum lumen] (Mus musculus)

P4HA1 [endoplasmic reticulum lumen] (Rattus norvegicus)

P4HA1 [endoplasmic reticulum lumen] (Sus scrofa)

Cross References

RefSeq

NP_001136067.1, NP_001136068.1, NP_001017962.1, NP_000908.2

OpenTargets

ENSG00000122884

HPA

ENSG00000122884-P4HA1

GeneCards

P13674

Ensembl

ENSP00000307318, ENST00000307116, ENSP00000263556, ENST00000440381, ENSP00000362099, ENSG00000122884, ENSP00000414464, ENST00000263556, ENST00000373008, ENST00000394890, ENSP00000378353

ZINC target

P13674

PRO

P13674

Pharos - Targets

P13674

ZINC - Predictions - Purchasable

P4HA1_HUMAN

HMDB Protein

HMDBP00304

PDB

4BTA, 4BTB, 4BT9, 1TJC, 2V5F, 2YQ8, 4BT8

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2

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