Reactome | P4HA1 [endoplasmic reticulum lumen]

P4HA1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-2980917

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Prolyl 4-hydroxylase subunit alpha-1, P4HA1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P13674 P4HA1

Gene Names

P4HA1, P4HA

Chain

signal peptide:1-17, chain:18-534

Reference Genes

BioGPS Gene:5033 P4HA1

COSMIC (genes):P4HA1 P4HA1

CTD Gene:5033 P4HA1

dbSNP Gene:5033 P4HA1

ENSEMBL:ENSG00000122884 P4HA1

HGNC:8546 P4HA1

KEGG:hsa:5033 P4HA1

Monarch:5033 P4HA1

NCBI Entrez Gene:5033 P4HA1

OMIM:176710 P4HA1

UCSC:P13674 P4HA1

Reference Transcript

Other Identifiers

11730853_s_at

16715361

207543_PM_s_at

207543_s_at

2673077

2713645

2911213

3035924

3294156

3294158

3294160

3294161

3294162

3294163

3294164

3294165

3294166

3294167

3294168

3294169

3294170

3294171

3294172

3294174

3294176

3294179

3294180

3294184

3294186

3294188

3294190

3294191

3294196

3294200

3294201

3294202

3294203

3294204

3294210

3309210

3309213

3631661

37037_at

3807488

3807499

3807500

5033

7892831

7895256

7895674

7934278

88134_at

A_24_P406693

A_33_P3214481

GE57882

GO:0003824

GO:0004656

GO:0005506

GO:0005515

GO:0005581

GO:0005739

GO:0005783

GO:0005788

GO:0016020

GO:0016222

GO:0016491

GO:0016705

GO:0030198

GO:0030199

GO:0031418

GO:0042802

GO:0046872

GO:0051213

GO:0140096

HMNXSV003040556

ILMN_1693334

ILMN_1747442

M24486_s_at

PH_hs_0004428

TC10001398.hg

g4505564_3p_a_at

Participates

as a member of

Prolyl 4-hydroxylase alpha subunits [endoplasmic reticulum lumen] (Homo sapiens)

Inferred To

LOC100492280 [endoplasmic reticulum lumen] (Xenopus tropicalis)

p4ha1b [endoplasmic reticulum lumen] (Danio rerio)

P4HA1 [endoplasmic reticulum lumen] (Bos taurus)

P4HA1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

P4HA1 [endoplasmic reticulum lumen] (Canis familiaris)

P4HA1 [endoplasmic reticulum lumen] (Gallus gallus)

P4HA1 [endoplasmic reticulum lumen] (Mus musculus)

P4HA1 [endoplasmic reticulum lumen] (Rattus norvegicus)

P4HA1 [endoplasmic reticulum lumen] (Sus scrofa)

Cross References

RefSeq

NP_000908.2, NP_001136067.1, NP_001136068.1, NP_001017962.1

OpenTargets

ENSG00000122884

ENSEMBL

ENST00000394890, ENSP00000307318, ENST00000440381, ENSP00000378353, ENSP00000362099, ENST00000263556, ENSG00000122884, ENSP00000263556, ENSP00000414464, ENST00000307116, ENST00000373008

ZINC - Substances

P4HA1_HUMAN

ZINC target

P13674

PRO

P13674

GlyGen

P13674

PDB

2YQ8, 1TJC, 2V5F, 4BTB, 4BTA, 4BT9, 4BT8

HPA

ENSG00000122884-P4HA1

GeneCards

P4HA1

Pharos - Targets

P13674

ZINC - Predictions - Purchasable

P4HA1_HUMAN

HMDB Protein

HMDBP00304

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2

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