Reactome | FN1(32-2386) [platelet alpha granule lumen]

FN1(32-2386) [platelet alpha granule lumen]

Stable Identifier

R-HSA-114620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Fibronectin precursor, FN, Cold-insoluble globulin, CIG

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02751 FN1

Gene Names

FN1, FN

Chain

signal peptide:1-31, chain:32-2477, chain:627-702, chain:723-911, chain:723-903, chain:723-

Reference Genes

BioGPS Gene:2335 FN1

COSMIC (genes):FN1 FN1

CTD Gene:2335 FN1

dbSNP Gene:2335 FN1

ENSEMBL:ENSG00000115414 FN1

ENSEMBL_homo_sapiens_GENE:ENSG00000115414.21 FN1

HGNC:3778 FN1

KEGG Gene (Homo sapiens):2335 FN1

Monarch:2335 FN1

NCBI Gene:2335 FN1

OMIM:135600 FN1

UCSC:P02751 FN1

Reference Transcript

Other Identifiers

11739435_a_at

11739534_a_at

11739535_s_at

11739536_x_at

11745837_x_at

11749460_x_at

11755897_a_at

11757650_s_at

16908037

210495_PM_x_at

210495_x_at

211719_PM_x_at

211719_x_at

212464_PM_s_at

212464_s_at

214701_PM_s_at

214701_s_at

214702_PM_at

214702_at

216442_PM_x_at

216442_x_at

2335

2598258

2598260

2598262

2598263

2598264

2598265

2598266

2598267

2598268

2598269

2598270

2598271

2598273

2598276

2598277

2598280

2598281

2598284

2598286

2598287

2598288

2598289

2598290

2598294

2598296

2598299

2598301

2598302

2598304

2598306

2598307

2598308

2598310

2598313

2598314

2598318

2598321

2598324

2598325

2598328

2598329

2598330

2598331

2598334

2598335

2598338

2598339

2598340

2598342

2598344

2598346

2598350

2598351

2598352

2598353

2598354

2598356

2598357

2598358

2598359

2598360

2598362

2598363

2598367

2598371

2598372

2598373

2598374

2598375

2598376

2598377

2598378

311_s_at

31719_at

31720_s_at

45557_r_at

8058765

A_24_P119745

A_24_P334130

A_24_P85539

GE534426

GO:0001525

GO:0001932

GO:0002020

GO:0002376

GO:0005102

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005518

GO:0005576

GO:0005577

GO:0005604

GO:0005615

GO:0005783

GO:0005788

GO:0005793

GO:0005886

GO:0006953

GO:0006954

GO:0007044

GO:0007155

GO:0007160

GO:0007161

GO:0007229

GO:0007399

GO:0007507

GO:0008201

GO:0008284

GO:0008360

GO:0009611

GO:0010628

GO:0016324

GO:0016504

GO:0018149

GO:0023052

GO:0030154

GO:0030312

GO:0031012

GO:0031093

GO:0031410

GO:0033622

GO:0034330

GO:0034446

GO:0035987

GO:0036211

GO:0042060

GO:0042802

GO:0043226

GO:0043394

GO:0045773

GO:0048146

GO:0048856

GO:0048870

GO:0051702

GO:0051897

GO:0062023

GO:0065003

GO:0070062

GO:0070372

GO:0071635

GO:0072562

GO:0098772

GO:0150102

GO:1901166

GO:1904237

HMNXSV003006662

HMNXSV003014798

HMNXSV003034134

Hs.287820.2.A1_3p_s_at

Hs.321592.0.S1_3p_at

ILMN_1675646

ILMN_1778237

ILMN_2366463

PH_hs_0025088

TC02002747.hg

X02761_s_at

Participates

as a member of

Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

FN1(32-271) [extracellular region]

FN1(272-2386) [extracellular region]

FN1(32-?) [extracellular region]

FN1(?-2386) [extracellular region]

FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]

FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]

p-FN1 [endoplasmic reticulum lumen]

FN1 [endoplasmic reticulum lumen]

FN1(32-2386) [extracellular region]

Inferred To

FN1 [platelet alpha granule lumen] (Bos taurus)

FN1 [platelet alpha granule lumen] (Canis familiaris)

FN1 [platelet alpha granule lumen] (Gallus gallus)

FN1 [platelet alpha granule lumen] (Sus scrofa)

fn1 [platelet alpha granule lumen] (Xenopus tropicalis)

FN1(32-2386) [platelet alpha granule lumen] (Caenorhabditis elegans)

sadA [platelet alpha granule lumen] (Dictyostelium discoideum)

Fn1 [platelet alpha granule lumen] (Mus musculus)

Fn1 [platelet alpha granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_997643.1, NP_001293060.1, NP_997647.1, XP_005246463.1, NP_473375.2, NP_997639.1, NP_001293059.1, NP_002017.1, NP_997641.1, NP_001293061.1, NP_001293058.1

OpenTargets

ENSG00000115414

ZINC - Substances

FINC_HUMAN

ZINC target

P02751

PRO

P02751

PDB

6MFA, 3EJH, 4JEG, 2HA1, 2FN2, 5DFT, 1O9A, 5DC9, 2CK2, 2CG7, 2OCF, 2MNU, 3MQL, 4GH7, 4MMY, 1TTF, 1FNA, 4MMZ, 5J6Z, 2FNB, 5M0A, 1OWW, 1QO6, 1FNH, 1TTG, 1FNF, 5N47, 2CG6, 6XAX, 5N48, 2CKU, 4MMX, 2RKY, 3R8Q, 3GXE, 2N1K, 2RL0, 1QGB, 3ZRZ, 6NAJ, 1FBR, 2RKZ, 5DC0, 3T1W, 5DC4, 2H41, 5J7C, 1Q38, 4PZ5, 4JE4, 2H45, 1E8B, 1J8K, 7NWL, 2GEE, 1E88, 2EC3, 6XAY, 6HNF, 3CAL, 6MSV, 3M7P, 4LXO

HPA

ENSG00000115414-FN1

GeneCards

P02751

Ensembl

ENST00000443816, ENSP00000394423, ENSP00000399538, ENSP00000410422, ENSP00000350534, ENSP00000415018, ENSP00000352696, ENST00000446046, ENSG00000115414, ENST00000421182, ENST00000357867, ENSP00000398907, ENST00000354785, ENSP00000323534, ENST00000323926, ENST00000359671, ENST00000356005, ENST00000432072, ENST00000336916, ENSP00000338200, ENSP00000348285, ENST00000426059, ENSP00000346839

Pharos - Targets

P02751

ZINC - Predictions - Purchasable

FINC_HUMAN

Orphanet

17365

HMDB Protein

HMDBP02074

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.891	8
ChEBI:28304 HEPARIN			0.845	6
UniProt:P08648 ITGA5	1	ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.839	11
UniProt:P21980 TGM2			0.811	5
UniProt:P14738 FNBA			0.789	23
UniProt:P05106 ITGB3	3	p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) ITGB3 [plasma membrane] (R-HSA-57600)	0.75	5
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.745	12
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773) ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [plasma membrane] (R-HSA-210013)	0.743	4
UniProt:Q53682 Q53682			0.743	19
UniProt:Q53971 Q53971			0.719	4
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.713	3
UniProt:Q93ED6 Q93ED6			0.675	8
IntAct:EBI-2528478 COLLAGEN			0.667	5
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.65	5
UniProt:Q9CKF6 Q9CKF6			0.623	5
UniProt:P11684 UTER			0.618	3
UniProt:P07996 THBS1	5	THBS1 [extracellular region] (R-HSA-66518) THBS1 [platelet alpha granule lumen] (R-HSA-114701) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263)	0.609	2
UniProt:P07585 DCN	20	DCN(31-?) [extracellular region] (R-HSA-2534171) DCN(?-359) [extracellular region] (R-HSA-2534176) DCN [extracellular region] (R-HSA-1430775) D2,4,4(S)3-DCN [lysosomal lumen] (R-HSA-2065105) D2,4(S)2-DCN [lysosomal lumen] (R-HSA-2065249) D4S-DCN [lysosomal lumen] (R-HSA-2065225) DCN [lysosomal lumen] (R-HSA-2065260) CSE-DCN [lysosomal lumen] (R-HSA-2065120) C6S-DCN [lysosomal lumen] (R-HSA-2065118) C4S-DCN [lysosomal lumen] (R-HSA-2065094) CSE-DCN [extracellular region] (R-HSA-2063955) C6S-DCN [extracellular region] (R-HSA-2064182) C4S-DCN [extracellular region] (R-HSA-2064029) CSE-DCN [Golgi lumen] (R-HSA-2064056) C6S-DCN [Golgi lumen] (R-HSA-2064145) D4S-DCN [extracellular region] (R-HSA-2065254) D2,4(S)2-DCN [extracellular region] (R-HSA-2065241) D2,4,4(S)3-DCN [extracellular region] (R-HSA-2065093) chondroitin(1)-DCN [Golgi lumen] (R-HSA-2064248) chondroitin(2)-DCN [Golgi lumen] (R-HSA-2063993)	0.602	9
UniProt:P08519 LPA	1	LPA [extracellular region] (R-HSA-176877)	0.592	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.564	3
UniProt:Q4AAD6 Q4AAD6			0.558	3
UniProt:P28300-PRO_0000018520 LOX			0.558	2
UniProt:P23568 EFTU			0.558	2
UniProt:P98066 TNFAIP6	3	TNFAIP6 [tertiary granule lumen] (R-HSA-6803341) TNFAIP6 [extracellular region] (R-HSA-6803348) TNFAIP6 [ficolin-1-rich granule lumen] (R-HSA-6803311)	0.558	8
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q15942 ZYX			0.547	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.547	2
UniProt:P05154 SERPINA5	1	SERPINA5 [extracellular region] (R-HSA-5591085)	0.544	3
UniProt:O75636 FCN3	1	FCN3 [extracellular region] (R-HSA-2530443)	0.544	3
UniProt:P50395 GDI2	4	GDI2 [cytosol] (R-HSA-195089) GDI2 [azurophil granule lumen] (R-HSA-6799337) GDI2 [extracellular region] (R-HSA-6806176) GDI2 [secretory granule lumen] (R-HSA-6800904)	0.527	2
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.527	2
UniProt:Q601D1 Q601D1			0.524	2
UniProt:Q9NY15 STAB1	2	STAB1 [endocytic vesicle membrane] (R-HSA-2239447) STAB1 [plasma membrane] (R-HSA-2197768)	0.508	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.506	2
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.499	2
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.491	2
UniProt:C5MHM7 C5MHM7			0.462	2
UniProt:G8BA52 G8BA52			0.462	2
UniProt:C5MBE7 C5MBE7			0.462	2
UniProt:G8B999 G8B999			0.462	2
UniProt:C5MAS1 C5MAS1			0.462	2
UniProt:G8BE22 G8BE22			0.462	2
UniProt:G8BCH3 G8BCH3			0.462	2

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