Reactome | ERAL1 [mitochondrial matrix]

ERAL1 [mitochondrial matrix]

Stable Identifier

R-HSA-8932742

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

GTPase Era, mitochondrial, ERAL1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20430825	ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation Uchiumi, T, Ohgaki, K, Yagi, M, Aoki, Y, Sakai, A, Matsumoto, S, Kang, D	Nucleic Acids Res.	2010
20604745	Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit Dennerlein, S, Rozanska, A, Wydro, M, Chrzanowska-Lightowlers, ZM, Lightowlers, RN	Biochem. J.	2010

External Reference Information

External Reference

UniProt:O75616 ERAL1

Gene Names

ERAL1, HERA

Chain

transit peptide:1-43, chain:44-437

Reference Genes

BioGPS Gene:26284 ERAL1

COSMIC (genes):ERAL1 ERAL1

CTD Gene:26284 ERAL1

dbSNP Gene:26284 ERAL1

ENSEMBL:ENSG00000132591 ERAL1

HGNC:3424 ERAL1

KEGG:hsa:26284 ERAL1

Monarch:26284 ERAL1

NCBI Gene:26284 ERAL1

OMIM:607435 ERAL1

UCSC:O75616 ERAL1

Reference Transcript

Other Identifiers

11756662_a_at

16832610

16832627

17119072

212087_PM_s_at

212087_s_at

26284

34379_at

3715887

3715888

3715889

3715890

3715892

3715893

3715894

3715895

3715896

3715897

3715898

3715899

3715900

3715901

3715902

3715903

3715904

3715906

3715907

8005994

A_14_P115679

A_23_P71981

GE54729

GO:0000028

GO:0000166

GO:0003723

GO:0005515

GO:0005525

GO:0005739

GO:0005743

GO:0005759

GO:0005829

GO:0016020

GO:0019843

GO:0042254

GO:0043024

GO:0065003

HMNXSV003020325

HMNXSV003035874

HMNXSV003048133

Hs.3426.0.S1_3p_a_at

ILMN_1718706

PH_hs_0030897

TC17000332.hg

TC17000333.hg

Participates

as a component of

28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)

Inferred To

eral1 [mitochondrial matrix] (Danio rerio)

eral1 [mitochondrial matrix] (Xenopus tropicalis)

Eral1 [mitochondrial matrix] (Mus musculus)

Eral1 [mitochondrial matrix] (Rattus norvegicus)

Dmel\CG7488 [mitochondrial matrix] (Drosophila melanogaster)

eral-1 [mitochondrial matrix] (Caenorhabditis elegans)

ERAL1 [mitochondrial matrix] (Bos taurus)

ERAL1 [mitochondrial matrix] (Canis familiaris)

ERAL1 [mitochondrial matrix] (Gallus gallus)

ERAL1 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_005693.1, NP_001304915.1, NP_001304914.1

ENSEMBL

ENSG00000132591, ENSP00000254928, ENST00000254928

OpenTargets

ENSG00000132591

GeneCards

ERAL1

HPA

ENSG00000132591-ERAL1

PRO

O75616

Pharos - Targets

O75616

GlyGen

O75616

Orphanet

ERAL1

HMDB Protein

HMDBP08380

PDB

8CSQ, 8CSP

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.527	2
UniProt:P08123 COL1A2	20	GlcGalHyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2023602) 3x4Hyp-3Hyp-GalHyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2023558) GalHyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2023547) 3x4Hyp-GlcGalHyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2023674) 3x4Hyp-GalHyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2023580) 3x4Hyp-3Hyp-GlcGalHyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2023663) 3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen] (R-HSA-2022070) 3x4Hyp-3Hyp-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2022501) 3x4Hyp-5Hyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2022977) 3x4Hyp-3Hyp-5Hyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2022966) 5Hyl-COL1A2(23-1366) [endoplasmic reticulum lumen] (R-HSA-2022455) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396490) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396080) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396375) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396493) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396241) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396064) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396361) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396431) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region] (R-HSA-2396174)	0.527	2