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CASP2(2-452) [cytosol]
Stable Identifier
R-HSA-622412
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Procaspase-2, CASP2, CASP2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
The PIDDosome activates CASP2 (Homo sapiens)
PIDDosome:CASP2(2-452) [cytosol] (Homo sapiens)
CASP2(2-452) [cytosol] (Homo sapiens)
The PIDDosome binds CASP2 (Homo sapiens)
CASP2(2-452) [cytosol] (Homo sapiens)
PIDDosome:CASP2(2-452) [cytosol] (Homo sapiens)
CASP2(2-452) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)
Long prodomain caspases [cytosol] (Homo sapiens)
CASP2(2-452) [cytosol] (Homo sapiens)
NOD1:iE-DAP:Long prodomain caspases [cytosol] (Homo sapiens)
Long prodomain caspases [cytosol] (Homo sapiens)
CASP2(2-452) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NADE modulates death signalling (Homo sapiens)
p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
Procaspases 2, 3 [cytosol] (Homo sapiens)
CASP2(2-452) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42575 CASP2
Gene Names
CASP2, ICH1, NEDD2
Chain
initiator methionine:1, propeptide:2-169, chain:170-325, propeptide:326-333, chain:334-452, chain:348-452
Reference Genes
BioGPS Gene:835 CASP2
COSMIC (genes):CASP2 CASP2
CTD Gene:835 CASP2
dbSNP Gene:835 CASP2
ENSEMBL:ENSG00000106144 CASP2
HGNC:1503 CASP2
KEGG Gene (Homo sapiens):835 CASP2
Monarch:835 CASP2
NCBI Gene:835 CASP2
OMIM:600639 CASP2
UCSC:P42575 CASP2
Reference Transcript
RefSeq:NM_001224.4 CASP2
RefSeq:NM_032982.3 CASP2
RefSeq:NM_032983.3 CASP2
Other Identifiers
0006020279
11720034_x_at
11720035_s_at
11720036_a_at
1239_s_at
1240_at
17052776
208050_s_at
209811_3p_at
209811_at
209812_x_at
211140_s_at
226032_at
226036_3p_x_at
226036_x_at
3029031
3029032
3029036
3029037
3029038
3029039
3029041
3029042
3029043
3029044
3029050
3029051
3029056
3029058
3029060
3029061
3029062
3029063
34448_s_at
34449_at
48571_at
8136869
835
A_14_P137967
A_23_P215701
A_23_P387943
A_24_P269398
A_33_P3308387
GE58937
GO:0000003
GO:0000278
GO:0001554
GO:0003407
GO:0003674
GO:0004197
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006508
GO:0006915
GO:0006919
GO:0006950
GO:0006977
GO:0007049
GO:0007165
GO:0007420
GO:0007568
GO:0008150
GO:0008219
GO:0008233
GO:0008234
GO:0008630
GO:0016020
GO:0016485
GO:0016787
GO:0019899
GO:0019904
GO:0030154
GO:0035234
GO:0042802
GO:0042981
GO:0043065
GO:0043066
GO:0043226
GO:0043525
GO:0048856
GO:0051604
GO:0071260
GO:0097153
GO:0097190
GO:0097192
GO:0097194
GO:0097199
GO:0097200
GO:2001235
Hs.180552.0.A1_3p_x_at
Hs.180552.0.A2_3p_at
Hs.180552.0.A2_3p_x_at
ILMN_1736568
ILMN_2296057
ILMN_2410540
PH_hs_0025267
TC07000932.hg
U13021_s_at
U13022_at
g12642589_3p_a_at
g12642589_3p_s_at
g4502574_3p_s_at
Participant Of
hasCandidate
Long prodomain caspases [cytosol]
hasMember
Procaspases 2, 3 [cytosol]
hasComponent
PIDDosome:CASP2(2-452) [cytosol]
input
The PIDDosome binds CASP2
Other forms of this molecule
CASP2(348-452) [cytosol]
CASP2(170-325) [cytosol]
Inferred To
Casp2 [cytosol] (Mus musculus)
Casp2 [cytosol] (Rattus norvegicus)
Dronc [cytosol] (Drosophila melanogaster)
CASP2 [cytosol] (Bos taurus)
CASP2 [cytosol] (Canis familiaris)
CASP2(2-452) [cytosol] (Gallus gallus)
CASP2(2-452) [cytosol] (Sus scrofa)
casp2 [cytosol] (Danio rerio)
casp2 [cytosol] (Xenopus tropicalis)
ced-3 [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
NP_116764.2
,
NP_001215.1
,
NP_116765.2
ZINC - World Drugs
CASP2_HUMAN
OpenTargets
ENSG00000106144
ZINC - Substances
CASP2_HUMAN
ZINC - Biogenic
CASP2_HUMAN
ZINC target
P42575
PRO
P42575
PDB
6GKF
,
3R5J
,
3R7S
,
2P2C
,
3R7N
,
3RJM
,
6S9K
,
3R7B
,
3R6L
,
6GKG
,
6SAD
,
1PYO
,
3R6G
ZINC - Metabolites
CASP2_HUMAN
HPA
ENSG00000106144-CASP2
GeneCards
P42575
Ensembl
ENSP00000312664
,
ENSG00000106144
,
ENST00000310447
ZINC - Predictions - Purchasable
CASP2_HUMAN
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78560 CRADD
1
CRADD [cytosol]
(R-HSA-5657970)
0.97
24
UniProt:P42575 CASP2
3
CASP2(348-452) [cytosol]
(R-HSA-2976745)
CASP2(2-452) [cytosol]
(R-HSA-622412)
CASP2(170-325) [cytosol]
(R-HSA-2976746)
0.87
11
UniProt:Q9HB75 PIDD1
3
p-T788-PIDD1 [nucleoplasm]
(R-HSA-6800485)
p-T788-PIDD1 [cytosol]
(R-HSA-6800271)
PIDD1 [nucleoplasm]
(R-HSA-6800483)
0.63
5
UniProt:O95429 BAG4
3
BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126):FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.556
3
UniProt:O43741 PRKAB2
3
PRKAB2 [nucleoplasm]
(R-HSA-164096)
PRKAB2 [cytosol]
(R-HSA-200413)
PRKAB2 [cytosol]
(R-HSA-200411)
0.556
3
UniProt:P53829 CAF40
0.556
3
UniProt:P42575-1 CASP2
0.508
2
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