Reactome | Prkab2 [cytosol]

Prkab2 [cytosol]

Stable Identifier

R-MMU-200413

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PRKAB2, Q6PAM0

Locations in the PathwayBrowser

Expand all

Autophagy (Mus musculus)

- Macroautophagy (Mus musculus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)
    - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
      - p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - Thr-180 of ULK1 is phosphorylated (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - ULK complex translocates to the ER (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - ULK1 phosphorylates Beclin-1 (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - p-AMPK:AMP binds the ULK complex (Mus musculus)
    - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
      - p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)
    - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
      - p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Metabolic Genes (Mus musculus)
        
        SESN1,2,3 bind AMPK (Mus musculus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK beta [cytosol] (Mus musculus)
        
        Prkab2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6PAM0 Prkab2

Gene Names

Prkab2

Chain

chain:1-271

Reference Genes

BioGPS Gene:108097 Prkab2

KEGG:mmu:108097 Prkab2

Monarch:108097 Prkab2

NCBI Gene:108097 Prkab2

UCSC:Q6PAM0 Prkab2

Reference Transcript

Other Identifiers

10494574

108097

111547_at

111548_g_at

113691_at

115323_at

1435874_at

1435875_at

1442001_at

17400788

4513167

4664501

4706224

4790905

4818357

4864901

4903051

4943055

5081583

5125872

5189530

5255424

5413836

5472744

5584792

A_51_P264781

A_52_P126266

GE102205

GE1486382

GO:0003824

GO:0004679

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006629

GO:0006631

GO:0006633

GO:0007165

GO:0016740

GO:0019901

GO:0031588

GO:0031669

GO:0120162

GO:0140096

ILMN_1215061

mMC014988

Participates

as a component of

AMPK heterotrimer (active) [cytosol] (Mus musculus)

as a member of

AMPK beta [cytosol] (Mus musculus)

Other forms of this molecule

Prkab2 [nucleoplasm]

Prkab2 [endoplasmic reticulum lumen]

Prkab2 [nucleoplasm]

Prkab2 [cytosol]

Inferred From

PRKAB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_011238284.1, XP_006500903.1, NP_892042.2

ENSEMBL

ENSMUSP00000036410, ENSMUST00000045743, ENSMUSG00000038205

PRO

Q6PAM0

GlyGen

Q6PAM0

MGI

1336185

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