Reactome | GRIN2C [endoplasmic reticulum membrane]

GRIN2C [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9609761

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Glutamate (NMDA) receptor subunit epsilon-3, NR2C

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14957 GRIN2C

Gene Names

GRIN2C, NMDAR2C

Chain

signal peptide:1-19, chain:20-1233

Reference Genes

BioGPS Gene:2905 GRIN2C

COSMIC (genes):GRIN2C GRIN2C

CTD Gene:2905 GRIN2C

dbSNP Gene:2905 GRIN2C

ENSEMBL:ENSG00000161509 GRIN2C

ENSEMBL:ENSG00000161509.14 GRIN2C

HGNC:4587 GRIN2C

KEGG Gene (Homo sapiens):2905 GRIN2C

Monarch:2905 GRIN2C

NCBI Gene:2905 GRIN2C

OMIM:138254 GRIN2C

UCSC:Q14957 GRIN2C

Reference Transcript

RefSeq:NM_000835.4 GRIN2C

Other Identifiers

11740655_at

16848640

210400_PM_at

210400_at

2905

3770423

3770424

3770425

3770426

3770427

3770428

3770429

3770432

3770433

3770435

3770437

3770438

3770440

3770441

3770442

3770443

3770444

3770445

3770448

3770453

41539_at

8018220

A_23_P49546

A_24_P25530

GE59418

GO:0004970

GO:0004972

GO:0005215

GO:0005216

GO:0005261

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006811

GO:0007215

GO:0007420

GO:0009611

GO:0015276

GO:0016020

GO:0017146

GO:0019722

GO:0022849

GO:0022890

GO:0023052

GO:0030163

GO:0033058

GO:0034220

GO:0035235

GO:0035249

GO:0038023

GO:0042177

GO:0042391

GO:0043226

GO:0045202

GO:0045211

GO:0048167

GO:0048168

GO:0048856

GO:0050877

GO:0050885

GO:0051968

GO:0055085

GO:0060079

GO:0060089

GO:0060291

GO:0097060

GO:0097553

GO:0098655

GO:0098839

GO:0098976

GO:0098978

GO:1903539

GO:1904062

GO:1904315

GO:2000463

HMNXSV003015376

HMNXSV003042745

ILMN_2227790

L76224_at

PH_hs_0025556

TC17001863.hg

g1196448_3p_at

Participates

as an input of

as a component of

Other forms of this molecule

GRIN2C [plasma membrane]

p-Y-GRIN2C [plasma membrane]

Inferred To

Homologues of GRIN2C [endoplasmic reticulum membrane] (Danio rerio)

GRIN2C [endoplasmic reticulum membrane] (Canis familiaris)

GRIN2C [endoplasmic reticulum membrane] (Danio rerio)

GRIN2C [endoplasmic reticulum membrane] (Gallus gallus)

GRIN2C [endoplasmic reticulum membrane] (Mus musculus)

GRIN2C [endoplasmic reticulum membrane] (Rattus norvegicus)

GRIN2C [endoplasmic reticulum membrane] (Sus scrofa)

Nmdar2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

nmr-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

grin2c [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000826.2

Guide to Pharmacology - Targets

458

OpenTargets

ENSG00000161509

GeneCards

Q14957

HPA

ENSG00000161509-GRIN2C

Ensembl

ENSG00000161509, ENSP00000293190, ENST00000293190

ZINC target

Q14957

PRO

Q14957

Pharos - Targets

Q14957

ZINC - Predictions - Purchasable

NMDE3_HUMAN

HMDB Protein

HMDBP01643

PDB

8E93, 8E99, 8E92, 8E94, 8E98, 8E97

Interactors (113)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135)	0.558	4
UniProt:Q62936	2	Dlg3 [cytosol] (R-RNO-6794232) Dlg3 [plasma membrane] (R-RNO-443609)	0.558	6
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.558	2
UniProt:P41271-2 NBL1			0.556	3
UniProt:Q5T0J7-2 TEX35			0.556	3
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.556	3
UniProt:Q96LL4 CH048			0.556	3
UniProt:Q9H0X6 RN208			0.556	3
UniProt:Q9UPQ4-2 Q9UPQ42			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:B7Z3E8 B7Z3E8			0.556	3
IntAct:EBI-25836264 CCSB			0.556	3
UniProt:Q06323 PSME1	2	PSME1 [nucleoplasm] (R-HSA-174320) PSME1 [cytosol] (R-HSA-68812)	0.556	3
UniProt:Q5BJF6-2 ODF2			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q8NDH6-2 ICA1L			0.556	3
UniProt:P02458-1 COL2A1			0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:Q68G74 LHX8			0.556	3
UniProt:Q658K8 EF1DL			0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:O60902-3 SHOX2			0.556	3
UniProt:O60237-2 PPP1R12B			0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:Q1L5Z9 LONF2			0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:Q6PHZ7 Q6PHZ7			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P49459 UBE2A	3	UBE2A [cytosol] (R-HSA-947617) Ub-C88-UBE2A [nucleoplasm] (R-HSA-8864186) UBE2A [nucleoplasm] (R-HSA-8852048)	0.556	3
UniProt:Q49A26-4 GLYR1			0.556	3
UniProt:Q6IN84-2 MRM1			0.556	3
UniProt:Q14117 DPYS	1	DPYS [cytosol] (R-HSA-73467)	0.556	3
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q5PSV4 BRM1L			0.556	3
IntAct:EBI-25839678 CCSB			0.556	3
UniProt:Q96LR2 LURA1			0.556	3
UniProt:Q5SXH7-1 PLEKHS1			0.556	3
UniProt:Q9NR21-5 PARP11			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:D3DX41 D3DX41			0.556	3
UniProt:Q5M9N0-2 CCDC158			0.556	3
UniProt:Q9Y6W6 DUSP10	2	DUSP10 [nucleoplasm] (R-HSA-203793) DUSP10 [cytosol] (R-HSA-5675334)	0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
UniProt:Q8NDP9 Q8NDP9			0.556	3
IntAct:EBI-25849055 CCSB			0.556	3
UniProt:Q3KNS6-3 Q3KNS63			0.556	3
UniProt:P47804-3 P478043			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q5T447-2 Q5T4472			0.556	3
UniProt:Q8IUR5-4 TMTC1			0.556	3
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q9NPC6 MYOZ2			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q9BPU6 DPYSL5	3	p-Y-DPYSL5 [cytosol] (R-HSA-399786) DPYSL5 [cytosol] (R-HSA-398138) p-S534-DPYSL5 [cytosol] (R-HSA-399793)	0.556	3
UniProt:Q5W111-2 SPRYD7			0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q6ZR37 PKHG7			0.556	3
UniProt:Q9P1Q0-4 VPS54			0.556	3
UniProt:O60830 TIMM17B	2	TIMM17B [mitochondrial intermembrane space] (R-HSA-1955371) TIMM17B [mitochondrial inner membrane] (R-HSA-1252138)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.556	3
UniProt:Q495U3 Q495U3			0.556	3
UniProt:Q7Z7F0-4 KHDC4			0.556	3
UniProt:Q9NX94 WBP1L			0.556	3
UniProt:Q6PF05 TT23L			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:Q96H12 MSD3			0.556	3
UniProt:Q6ZN54-2 DEF8			0.556	3
UniProt:Q8WUD1-2 Q8WUD12			0.556	3
UniProt:P06454-2 PTMA			0.556	3
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.556	3
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.556	3
UniProt:Q96GL9 F163A			0.556	3
IntAct:EBI-25835796 CCSB			0.556	3
IntAct:EBI-25853226 CCSB			0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:Q9NP64 ZCC17			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q8N0U2 TMM61			0.556	3
UniProt:A0A0A0MR05 A0A0A0MR05			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:Q8N0U6 CF218			0.556	3
UniProt:Q99743 NPAS2	2	NPAS2 [cytosol] (R-HSA-400314) p-S-NPAS2 [nucleoplasm] (R-HSA-421309)	0.556	3
IntAct:EBI-25835824 RZPDO834E0719D			0.556	3
IntAct:EBI-25837563 CCSB			0.556	3
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q9BT25 HAUS8	1	HAUS8 [cytosol] (R-HSA-8855198)	0.556	3
UniProt:Q96JL9-2 Q96JL92			0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:Q7Z7J5 DPPA2	1	DPPA2 [nucleoplasm] (R-HSA-9816401)	0.556	3
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q9UJU6 DBNL	7	DBNL [tertiary granule lumen] (R-HSA-6801516) DBNL [secretory granule lumen] (R-HSA-6801520) DBNL [cytosol] (R-HSA-202880) DBNL(362-431) [cytosol] (R-HSA-202933) DBNL(1-361) [cytosol] (R-HSA-202925) DBNL [ficolin-1-rich granule lumen] (R-HSA-6801510) DBNL [extracellular region] (R-HSA-6801604)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.556	3
UniProt:Q9NZH6 IL37	6	IL37(?-218) [nucleoplasm] (R-HSA-9008702) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [extracellular region] (R-HSA-9008607) IL37 [cytosol] (R-HSA-9008596) IL37(?-218) [cytosol] (R-HSA-9008584) IL37(1-?) [cytosol] (R-HSA-9008602)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3

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