Reactome | CASP2(348-452) [cytosol]

CASP2(348-452) [cytosol]

Stable Identifier

R-HSA-2976745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-2 subunit p12, CASP2, CASP2_HUMAN

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        The PIDDosome activates CASP2 (Homo sapiens)
        
        CASP2(348-452) [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Death Receptor Signaling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
      - NADE modulates death signalling (Homo sapiens)
        
        p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
        
        Active Caspases 2, 3 [cytosol] (Homo sapiens)
        
        Active Caspase-2 heterotetramer [cytosol] (Homo sapiens)
        
        Caspase-2 [cytosol] (Homo sapiens)
        
        CASP2(348-452) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42575 CASP2

Gene Names

CASP2, ICH1, NEDD2

Chain

initiator methionine:, propeptide:2-169, chain:170-325, propeptide:326-333, chain:334-452, chain:348-452

Reference Genes

BioGPS Gene:835 CASP2

COSMIC (genes):CASP2 CASP2

CTD Gene:835 CASP2

dbSNP Gene:835 CASP2

ENSEMBL:ENSG00000106144 CASP2

HGNC:1503 CASP2

KEGG:hsa:835 CASP2

Monarch:835 CASP2

NCBI Gene:835 CASP2

OMIM:600639 CASP2

UCSC:P42575 CASP2

Reference Transcript

Participates

as an output of

The PIDDosome activates CASP2 (Homo sapiens)

as a component of

Caspase-2 [cytosol] (Homo sapiens)

Other forms of this molecule

CASP2(2-452) [cytosol]

CASP2(170-325) [cytosol]

Inferred To

Strica [cytosol] (Drosophila melanogaster)

Casp2 [cytosol] (Mus musculus)

Casp2 [cytosol] (Rattus norvegicus)

CASP2 [cytosol] (Bos taurus)

Dcp-1 [cytosol] (Drosophila melanogaster)

CASP2(348-452) [cytosol] (Gallus gallus)

Dredd [cytosol] (Drosophila melanogaster)

Drice [cytosol] (Drosophila melanogaster)

Homologues of CASP2(348-452) [cytosol] (Drosophila melanogaster)

Damm [cytosol] (Drosophila melanogaster)

Decay [cytosol] (Drosophila melanogaster)

casp2 [cytosol] (Danio rerio)

ced-3 [cytosol] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

1618

OpenTargets

ENSG00000106144

ENSEMBL

ENSG00000106144, ENST00000310447, ENSP00000312664

ZINC - Substances

CASP2_HUMAN

ZINC - Biogenic

CASP2_HUMAN

ZINC target

P42575

PRO

P42575

PDB

6S9K, 3R5J, 1PYO, 3R7N, 2P2C, 3R7S, 3R6L, 3R7B, 6Y8D, 3RJM, 6GKF, 6GKG, 6Y8B, 3R6G, 6SAD

ZINC - Metabolites

CASP2_HUMAN

HPA

ENSG00000106144-CASP2

GeneCards

CASP2

Pharos - Targets

P42575

ZINC - Predictions - Purchasable

CASP2_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78560 CRADD	1	CRADD [cytosol] (R-HSA-5657970)	0.973	32
UniProt:P42575 CASP2	3	CASP2(2-452) [cytosol] (R-HSA-622412) CASP2(348-452) [cytosol] (R-HSA-2976745) CASP2(170-325) [cytosol] (R-HSA-2976746)	0.87	11
UniProt:Q9HB75 PIDD1	3	p-T788-PIDD1 [cytosol] (R-HSA-6800271) p-T788-PIDD1 [nucleoplasm] (R-HSA-6800485) PIDD1 [nucleoplasm] (R-HSA-6800483)	0.63	5
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:P53829 CAF40			0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:O75936 BBOX1	1	BBOX1 [cytosol] (R-HSA-71104)	0.527	2
UniProt:P42575-1 CASP2			0.508	2

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