Reactome | CASP2(170-325) [cytosol]

CASP2(170-325) [cytosol]

Stable Identifier

R-HSA-2976746

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-2 subunit p18, CASP2, CASP2_HUMAN

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        The PIDDosome activates CASP2 (Homo sapiens)
        
        CASP2(170-325) [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Death Receptor Signaling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
      - NADE modulates death signalling (Homo sapiens)
        
        p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
        
        Active Caspases 2, 3 [cytosol] (Homo sapiens)
        
        Active Caspase-2 heterotetramer [cytosol] (Homo sapiens)
        
        Caspase-2 [cytosol] (Homo sapiens)
        
        CASP2(170-325) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42575 CASP2

Gene Names

CASP2, ICH1, NEDD2

Chain

initiator methionine:1, propeptide:2-169, chain:170-325, propeptide:326-333, chain:334-452, chain:348-452

Reference Genes

BioGPS Gene:835 CASP2

COSMIC (genes):CASP2 CASP2

CTD Gene:835 CASP2

dbSNP Gene:835 CASP2

ENSEMBL:ENSG00000106144.20 CASP2

HGNC:1503 CASP2

KEGG Gene (Homo sapiens):835 CASP2

Monarch:835 CASP2

NCBI Gene:835 CASP2

OMIM:600639 CASP2

UCSC:P42575 CASP2

Reference Transcript

Other Identifiers

0006020279

11720034_x_at

11720035_s_at

11720036_a_at

1239_s_at

1240_at

17052776

208050_PM_s_at

208050_s_at

209811_3p_at

209811_PM_at

209811_at

209812_PM_x_at

209812_x_at

211140_PM_s_at

211140_s_at

226032_PM_at

226032_at

226036_3p_x_at

226036_PM_x_at

226036_x_at

3029031

3029032

3029036

3029037

3029038

3029039

3029041

3029042

3029043

3029044

3029050

3029051

3029056

3029058

3029060

3029061

3029062

3029063

34448_s_at

34449_PM_at

34449_at

48571_at

8136869

835

A_14_P137967

A_23_P215701

A_23_P387943

A_24_P269398

A_33_P3308387

GE58937

GO:0000278

GO:0001554

GO:0003407

GO:0004197

GO:0005515

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0006508

GO:0006915

GO:0006919

GO:0006974

GO:0006977

GO:0007420

GO:0007568

GO:0008233

GO:0008234

GO:0008630

GO:0012501

GO:0016020

GO:0016485

GO:0016787

GO:0019899

GO:0019904

GO:0022414

GO:0023052

GO:0030154

GO:0032991

GO:0035234

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0043525

GO:0048856

GO:0051604

GO:0071260

GO:0097153

GO:0097190

GO:0097192

GO:0097194

GO:0097199

GO:0097200

GO:0140096

GO:1905369

GO:2001235

HMNXSV003026548

Hs.180552.0.A1_3p_x_at

Hs.180552.0.A2_3p_at

Hs.180552.0.A2_3p_x_at

ILMN_1736568

ILMN_2296057

ILMN_2410540

PH_hs_0025267

TC07000932.hg

U13021_s_at

U13022_at

g12642589_3p_a_at

g12642589_3p_s_at

g4502574_3p_s_at

Participates

as an output of

The PIDDosome activates CASP2 (Homo sapiens)

as a component of

Caspase-2 [cytosol] (Homo sapiens)

Other forms of this molecule

CASP2(348-452) [cytosol]

CASP2(2-452) [cytosol]

Inferred To

Casp2 [cytosol] (Mus musculus)

Casp2 [cytosol] (Rattus norvegicus)

CASP2 [cytosol] (Bos taurus)

CASP2 [cytosol] (Gallus gallus)

CASP2(170-325) [cytosol] (Canis familiaris)

CASP2(170-325) [cytosol] (Danio rerio)

Cross References

RefSeq

NP_116765.2, NP_001215.1, NP_116764.2

ZINC - World Drugs

CASP2_HUMAN

Guide to Pharmacology - Targets

1618

OpenTargets

ENSG00000106144

ZINC - Substances

CASP2_HUMAN

ZINC - Biogenic

CASP2_HUMAN

ZINC target

P42575

PRO

P42575

PDB

3R5J, 6GKF, 3R7S, 3R7N, 6Y8B, 3R6G, 3RJM, 2P2C, 1PYO, 6S9K, 3R6L, 6SAD, 6GKG, 3R7B, 6Y8D

ZINC - Metabolites

CASP2_HUMAN

HPA

ENSG00000106144-CASP2

GeneCards

P42575

Ensembl

ENSP00000312664, ENSG00000106144, ENST00000310447

Pharos - Targets

P42575

ZINC - Predictions - Purchasable

CASP2_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78560 CRADD	1	CRADD [cytosol] (R-HSA-5657970)	0.97	24
UniProt:P42575 CASP2	3	CASP2(170-325) [cytosol] (R-HSA-2976746) CASP2(348-452) [cytosol] (R-HSA-2976745) CASP2(2-452) [cytosol] (R-HSA-622412)	0.87	11
UniProt:Q9HB75 PIDD1	3	p-T788-PIDD1 [cytosol] (R-HSA-6800271) p-T788-PIDD1 [nucleoplasm] (R-HSA-6800485) PIDD1 [nucleoplasm] (R-HSA-6800483)	0.63	5
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:P53829 CAF40			0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:P42575-1 CASP2			0.508	2