Reactome | RAD21 [chromosome]

RAD21

Stable Identifier

R-HSA-1638775

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome

Synonyms

Double-strand-break repair protein rad21 homolog, SCC1 homolog, NXP1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60216 RAD21

Gene Names

RAD21, HR21, KIAA0078, NXP1, SCC1

Chain

chain:1-631

Reference Genes

BioGPS Gene:5885 RAD21

COSMIC (genes):RAD21 RAD21

CTD Gene:5885 RAD21

dbSNP Gene:5885 RAD21

ENSEMBL:ENSG00000164754 RAD21

HGNC:9811 RAD21

KEGG Gene (Homo sapiens):hsa:5885 RAD21

Monarch:5885 RAD21

NCBI Gene:5885 RAD21

OMIM:606462 RAD21

UCSC:O60216 RAD21

Reference Transcript

RefSeq:NM_006265.2 RAD21

Other Identifiers

0006420332

11716436_s_at

11716437_a_at

11716438_at

11754303_s_at

17080408

20044

200607_s_at

200608_s_at

22065

3149849

3149850

3149852

3149855

3149857

3149858

3149861

3149862

3149863

3149864

3149865

3149866

3149869

3149871

3149873

3149882

3149883

38114_at

3984533

3984537

4PJU

4PJW

4PK7

5885

8152477

A0A024R9J0

CAB022065

CCDS6321

D38551_at

ENSG00000164754

ENSP00000297338

ENST00000297338

EntrezGene:5885

g5453993_3p_a_at

GE57195

GO:0000228

GO:0000775

GO:0000785

GO:0000794

GO:0000798

GO:0001228

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006281

GO:0006302

GO:0006310

GO:0006357

GO:0006366

GO:0006915

GO:0006974

GO:0007049

GO:0007059

GO:0007062

GO:0007131

GO:0008278

GO:0010972

GO:0016020

GO:0016363

GO:0032403

GO:0045841

GO:0045876

GO:0045944

GO:0051301

GO:0071168

HGNC:9811

HPA020044

Hs.81848

Hs.81848.0.S1_3p_a_at

ILMN_1748578

LRG_772

LRG_772t1

MIM:606462

MIM:614701

NM_006265

NP_006256

PF04824

PF04825

PH_hs_0004675

RAD21

RAD21-201

TC08001546.hg

uc003yod.4

UPI0000133018

Participant Of

hasComponent

Ac-Cohesin Complex [chromosome]

Other forms of this molecule

p-S454-RAD21 [cytosol]

p-S454-RAD21 [chromosome]

RAD21 [nucleoplasm]

RAD21 [chromosome, centromeric region]

p-S454-RAD21 [chromosome, centromeric region]

RAD21(1-172) [chromosome, centromeric region]

p-S454-RAD21(451-631) [chromosome, centromeric region]

RAD21(173-450) [chromosome, centromeric region]

RAD21(1-172) [cytosol]

RAD21(173-450) [cytosol]

p-S454-RAD21(451-631) [cytosol]

RAD21 [cytosol]

SUMO1-K-RAD21 [nucleoplasm]

Inferred To

Homologues of RAD21 [chromosome] (Caenorhabditis elegans)

Homologues of RAD21 [chromosome] (Danio rerio)

Homologues of RAD21 [chromosome] (Drosophila melanogaster)

Homologues of RAD21 [chromosome] (Oryza sativa)

Homologues of RAD21 [chromosome] (Sus scrofa)

RAD21 [chromosome] (Arabidopsis thaliana)

RAD21 [chromosome] (Bos taurus)

RAD21 [chromosome] (Caenorhabditis elegans)

RAD21 [chromosome] (Canis familiaris)

RAD21 [chromosome] (Danio rerio)

RAD21 [chromosome] (Dictyostelium discoideum)

RAD21 [chromosome] (Drosophila melanogaster)

RAD21 [chromosome] (Gallus gallus)

RAD21 [chromosome] (Mus musculus)

RAD21 [chromosome] (Oryza sativa)

RAD21 [chromosome] (Rattus norvegicus)

RAD21 [chromosome] (Schizosaccharomyces pombe)

RAD21 [chromosome] (Sus scrofa)

RAD21 [chromosome] (Taeniopygia guttata)

RAD21 [chromosome] (Xenopus tropicalis)

Cross References

RefSeq

NP_006256.1

GeneCards

O60216

DOCK Blaster

4PJU, 4PJW, 4PK7

PRO

O60216

Orphanet

21189

PDB

4PK7, 4PJW, 4PJU

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UQE7 SMC3	6	SMC3 [nucleoplasm] (R-HSA-163009) 2xAcK-SMC3 [chromosome, centromeric region] (R-HSA-2468148) 2xAcK-SMC3 [nucleoplasm] (R-HSA-2468050) 2xAcK-SMC3 [chromosome] (R-HSA-2468146) SMC3 [cytosol] (R-HSA-2545223) 2xAcK-SMC3 [cytosol] (R-HSA-2484792)	0.946	15
UniProt:Q8N3U4 STAG2	8	STAG2 [cytosol] (R-HSA-2484897) SUMO1-K-STAG2 [nucleoplasm] (R-HSA-3108187) p-STAG2 [chromosome, centromeric region] (R-HSA-2466013) STAG2 [chromosome, centromeric region] (R-HSA-2466018) STAG2 [nucleoplasm] (R-HSA-163046) STAG2 [chromosome] (R-HSA-1638777) p-STAG2 [chromosome] (R-HSA-1638793) p-STAG2 [cytosol] (R-HSA-2484806)	0.944	13
UniProt:Q14683 SMC1A	4	SMC1A [nucleoplasm] (R-HSA-64561) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [chromosome] (R-HSA-1638774) SMC1A [cytosol] (R-HSA-2484798)	0.877	14
UniProt:Q7Z5K2 WAPL	4	WAPAL [nucleoplasm] (R-HSA-2466355) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [chromosome] (R-HSA-2577090) WAPAL [cytosol] (R-HSA-2484802)	0.832	15
UniProt:Q8WVM7 STAG1	4	STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [chromosome] (R-HSA-1638773) STAG1 [cytosol] (R-HSA-2484793)	0.823	8
UniProt:Q29RF7 PDS5A	4	PDS5A [nucleoplasm] (R-HSA-2468043) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [chromosome] (R-HSA-2466360) PDS5A [cytosol] (R-HSA-2484799)	0.758	4
UniProt:Q9NTI5 PDS5B	4	PDS5B [nucleoplasm] (R-HSA-2468051) PDS5B [chromosome, centromeric region] (R-HSA-2468263) PDS5B [chromosome] (R-HSA-2466361) PDS5B [cytosol] (R-HSA-2484800)	0.758	4
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.674	9
UniProt:Q9CPY3	6	CDCA5 [chromosome, centromeric region] (R-MMU-2468260) phospho-p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-MMU-2468269) CDCA5 [nucleoplasm] (R-MMU-2466357) CDCA5 [chromosome] (R-MMU-2468149) phospho-p-S21,S75,T159-CDCA5 [cytosol] (R-MMU-2484804) phospho-p-S21,S75,T159-CDCA5 [chromosome] (R-MMU-2468266)	0.669	3
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.643	5
UniProt:Q9CW03 Smc3	6	Structural maintenance of chromosomes protein 3 [nucleoplasm] (R-MMU-912387) 2xAcK-SMC3 [chromosome, centromeric region] (R-MMU-2468148) 2xAcK-SMC3 [nucleoplasm] (R-MMU-2468050) 2xAcK-SMC3 [chromosome] (R-MMU-2468146) SMC3 [cytosol] (R-MMU-2545223) 2xAcK-SMC3 [cytosol] (R-MMU-2484792)	0.597	5
UniProt:Q13643 FHL3			0.556	3