Reactome | RAD21 [chromosome]

RAD21 [chromosome]

Stable Identifier

R-HSA-1638775

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome

Synonyms

Double-strand-break repair protein rad21 homolog, SCC1 homolog, NXP1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60216 RAD21

Gene Names

RAD21, HR21, KIAA0078, NXP1, SCC1

Chain

chain:1-631, chain:280-631

Reference Genes

BioGPS Gene:5885 RAD21

COSMIC (genes):RAD21 RAD21

CTD Gene:5885 RAD21

dbSNP Gene:5885 RAD21

ENSEMBL:ENSG00000164754 RAD21

HGNC:9811 RAD21

KEGG Gene (Homo sapiens):5885 RAD21

Monarch:5885 RAD21

NCBI Gene:5885 RAD21

OMIM:606462 RAD21

UCSC:O60216 RAD21

Reference Transcript

RefSeq:NM_006265.2 RAD21

Other Identifiers

0006420332

11716436_s_at

11716437_a_at

11716438_at

11754303_s_at

17080408

200607_s_at

200608_s_at

3149849

3149850

3149852

3149855

3149857

3149858

3149861

3149862

3149863

3149864

3149865

3149866

3149869

3149871

3149873

3149882

3149883

38114_at

3984533

3984537

5885

8152477

D38551_at

GE57195

GO:0000003

GO:0000228

GO:0000278

GO:0000775

GO:0000785

GO:0000794

GO:0000795

GO:0000922

GO:0003674

GO:0003682

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0006259

GO:0006281

GO:0006302

GO:0006310

GO:0006357

GO:0006915

GO:0006950

GO:0006974

GO:0007049

GO:0007059

GO:0007062

GO:0007064

GO:0007130

GO:0007131

GO:0007275

GO:0008150

GO:0008219

GO:0008278

GO:0009058

GO:0010972

GO:0016020

GO:0016363

GO:0022607

GO:0032991

GO:0034641

GO:0034990

GO:0034991

GO:0043226

GO:0045841

GO:0045876

GO:0048856

GO:0051276

GO:0051301

GO:0071168

GO:0140014

GO:1990414

HMNXSV003020959

HMNXSV003027934

Hs.81848.0.S1_3p_a_at

ILMN_1748578

PH_hs_0004675

TC08001546.hg

g5453993_3p_a_at

Participates

as a component of

Ac-Cohesin Complex [chromosome] (Homo sapiens)

Other forms of this molecule

SUMO1-K-RAD21 [nucleoplasm]

RAD21 [nucleoplasm]

RAD21 [chromosome, centromeric region]

p-S454-RAD21 [chromosome, centromeric region]

RAD21(1-172) [chromosome, centromeric region]

p-S454-RAD21(451-631) [chromosome, centromeric region]

RAD21(173-450) [chromosome, centromeric region]

RAD21(1-172) [cytosol]

RAD21(173-450) [cytosol]

p-S454-RAD21(451-631) [cytosol]

RAD21 [cytosol]

p-S454-RAD21 [chromosome]

p-S454-RAD21 [cytosol]

Inferred To

MCD1 [chromosome] (Saccharomyces cerevisiae)

rad21b [chromosome] (Danio rerio)

Rad21 [chromosome] (Mus musculus)

Rad21 [chromosome] (Rattus norvegicus)

rad21 [chromosome] (Schizosaccharomyces pombe)

rad21 [chromosome] (Xenopus tropicalis)

scc-1 [chromosome] (Caenorhabditis elegans)

RAD21 [chromosome] (Canis familiaris)

RAD21 [chromosome] (Dictyostelium discoideum)

RAD21 [chromosome] (Gallus gallus)

RAD21 [chromosome] (Sus scrofa)

vtd [chromosome] (Drosophila melanogaster)

Cross References

RefSeq

NP_006256.1

OpenTargets

ENSG00000164754

GeneCards

O60216

HPA

ENSG00000164754-RAD21

Ensembl

ENST00000297338, ENSP00000297338, ENSG00000164754

PRO

O60216

Pharos - Targets

O60216

Orphanet

21189

PDB

6RRK, 6WG3, 6WGE, 4PJW, 6RRC, 4PK7, 4PJU, 6QNX

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N3U4 STAG2	8	p-STAG2 [chromosome, centromeric region] (R-HSA-2466013) STAG2 [nucleoplasm] (R-HSA-163046) STAG2 [chromosome, centromeric region] (R-HSA-2466018) p-STAG2 [cytosol] (R-HSA-2484806) SUMO1-K-STAG2 [nucleoplasm] (R-HSA-3108187) STAG2 [chromosome] (R-HSA-1638777) p-STAG2 [chromosome] (R-HSA-1638793) STAG2 [cytosol] (R-HSA-2484897)	0.962	19
UniProt:Q9UQE7 SMC3	6	2xAcK-SMC3 [cytosol] (R-HSA-2484792) 2xAcK-SMC3 [chromosome, centromeric region] (R-HSA-2468148) 2xAcK-SMC3 [nucleoplasm] (R-HSA-2468050) 2xAcK-SMC3 [chromosome] (R-HSA-2468146) SMC3 [cytosol] (R-HSA-2545223) SMC3 [nucleoplasm] (R-HSA-163009)	0.951	16
UniProt:Q14683 SMC1A	4	SMC1A [cytosol] (R-HSA-2484798) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [nucleoplasm] (R-HSA-64561) SMC1A [chromosome] (R-HSA-1638774)	0.91	15
UniProt:Q8WVM7 STAG1	4	STAG1 [cytosol] (R-HSA-2484793) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome] (R-HSA-1638773)	0.899	10
UniProt:Q7Z5K2 WAPL	4	WAPAL [nucleoplasm] (R-HSA-2466355) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [cytosol] (R-HSA-2484802)	0.832	15
UniProt:Q29RF7 PDS5A	4	PDS5A [cytosol] (R-HSA-2484799) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [chromosome] (R-HSA-2466360) PDS5A [nucleoplasm] (R-HSA-2468043)	0.813	5
UniProt:Q9NTI5 PDS5B	4	PDS5B [chromosome] (R-HSA-2466361) PDS5B [nucleoplasm] (R-HSA-2468051) PDS5B [cytosol] (R-HSA-2484800) PDS5B [chromosome, centromeric region] (R-HSA-2468263)	0.758	4
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.737	6
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.674	9
UniProt:Q9CPY3	6	Cdca5 [nucleoplasm] (R-MMU-2466357) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) Cdca5 [chromosome] (R-MMU-2468149) phospho-Cdca5 [chromosome] (R-MMU-2468266) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) phospho-Cdca5 [cytosol] (R-MMU-2484804)	0.669	3
UniProt:Q13643 FHL3			0.666	4
UniProt:Q9CW03 Smc3	6	Smc3 [chromosome] (R-MMU-2468146) Structural maintenance of chromosomes protein 3 [nucleoplasm] (R-MMU-912387) Smc3 [cytosol] (R-MMU-2545223) Smc3 [chromosome, centromeric region] (R-MMU-2468148) Smc3 [cytosol] (R-MMU-2484792) Smc3 [nucleoplasm] (R-MMU-2468050)	0.597	5
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [nucleoplasm] (R-HSA-2466357) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266)	0.527	2
UniProt:Q9NTI5-2 PDS5B			0.527	2
UniProt:Q8N3U4-2 STAG2			0.527	2

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